Novel single nucleotide polymorphism markers for low dose aspirin-associated small bowel bleeding

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Shiotani, Akiko ^a   Murao, Takahisa ^a   Fujita, Yoshihiko ^b   Fujimura, Yoshinori ^c   Sakakibara, Takashi ^c   Nishio, Kazuto ^b   Haruma, Ken ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c THE SAKAKIBARA HEART INSTITUTE OF OKAYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYTOCHROME P450 2D6; GLUTATHIONE TRANSFERASE P1; NONSTEROID ANTIINFLAMMATORY AGENT; WARFARIN;

ADULT; AGED; ALLELE; ARTICLE; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GENOTYPE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PHARMACOGENOMICS; SINGLE NUCLEOTIDE POLYMORPHISM; SMALL INTESTINE HEMORRHAGE; SMOKING;

ADULT; AGED; AGED, 80 AND OVER; ASPIRIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GASTROINTESTINAL HEMORRHAGE; GENETIC MARKERS; GENOMICS; HUMANS; INTESTINE, SMALL; MALE; MIDDLE AGED; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84893193933     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084244     Document Type: Article

References (32)

1. Shiotani A, Kamada T, Haruma K (2008) Low-dose aspirin-induced gastrointestinal diseases: past, present, and future. J Gastroenterol 43: 581-588. doi:10.1007/s00535-008-2206-5. PubMed: 18709479.
2. Endo H, Hosono K, Inamori M, Kato S, Nozaki Y et al. (2009) Incidence of small bowel injury induced by low-dose aspirin: a crossover study using capsule endoscopy in healthy volunteers. Digestion 79: 44-51. doi:10.1159/000204465. PubMed: 19246922.
3. Endo H, Hosono K, Inamori M, Nozaki Y, Yoneda K et al. (2009) Characteristics of small bowel injury in symptomatic chronic low-dose aspirin users: the experience of two medical centers in capsule endoscopy. J Gastroenterol, 44: 544-549. doi:10.1007/s00535-009-0040-z. PubMed: 19373431.
4. Smecuol E, Pinto Sanchez MI, Suarez A, Argonz JE, Sugai E et al. (2009) Low-dose aspirin affects the small bowel mucosa: results of a pilot study with a multidimensional assessment. Clin Gastroenterol Hepatol 7: 524-529. doi:10.1016/j.cgh.2008.12.019. PubMed: 19249402.
5. Watanabe T, Sugimori S, Kameda N, Machida H, Okazaki H et al. (2008) Small bowel injury by low-dose enteric-coated aspirin and treatment with misoprostol: a pilot study. Clin Gastroenterol Hepatol 6: 1279-1282. doi:10.1016/j.cgh.2008.06.021. PubMed: 18995219.
6. Hirata Y, Kataoka H, Shimura T, Mizushima T, Mizoshita T et al. (2011) Incidence of gastrointestinal bleeding in patients with cardiovascular disease: buffered aspirin versus enteric-coated aspirin. Scand J Gastroenterol 46: 803-809. doi:10.3109/00365521.2011.568522. PubMed: 21501103.
7. Nadatani Y, Watanabe T, Tanigawa T, Sogawa M, Yamagami H et al. (2013) Incidence and risk factors of gastrointestinal bleeding in patients on low-dose aspirin therapy after percutaneous coronary intervention in Japan. Scand J Gastroenterol 48: 320-325. doi:10.3109/00365521.2012.758771. PubMed: 23298342.
8. Antiplatelet Trialists' Collaboration (1994) Collaborative overview of randomised trials of antiplatelet therapy - II: Maintenance of vascular graft or arterial patency by antiplatelet therapy. BMJ 308(6922): 159-168.
9. Awtry EH, Loscalzo J (2000) Aspirin. Circulation 101: 1206-1218. doi:10.1161/01.CIR.101.10.1206. PubMed: 10715270.
10. Antithrombotic Trialists' Collaboration (2002) Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324: 71-86. doi:10.1136/bmj.324.7336.S71. PubMed: 11786451.
11. Cooke GE, Goldschmidt-Clermont PJ (2006) The safety and efficacy of aspirin and clopidogrel as a combination treatment in patients with coronary heart disease. Expert Opin Drug Saf 5: 815-826. doi:10.1517/14740338.5.6.815. PubMed: 17044808.
12. Dai X, Makaryus AN, Makaryus JN, Jauhar R (2009) Significant gastrointestinal bleeding in patients at risk of coronary stent thrombosis. Rev Cardiovasc Med, 10: 14-24. PubMed: 19367228.
13. Tan VP, Yan BP, Kiernan TJ, Ajani AE (2009) Risk and management of upper gastrointestinal bleeding associated with prolonged dual-antiplatelet therapy after percutaneous coronary intervention. Cardiovasc Revasc Med 10: 36-44. doi:10.1016/j.carrev.2008.11.001. PubMed: 19159853.
14. Shiotani A, Sakakibara T, Yamanaka Y, Imamura H, Tarumi K et al. (2009) Upper gastrointestinal ulcer in Japanese patients taking low-dose aspirin. J Gastroenterol 44: 126-131. doi:10.1007/s00535-008-2290-6. PubMed: 19214674.
15. Shiotani A, Sakakibara T, Nomura M, Yamanaka Y, Nishi R et al. (2010) Aspirin-induced peptic ulcer and genetic polymorphisms. J Gastroenterol Hepatol 25 Suppl 1: S31-S34. doi:10.1111/j.1440-1746.2009.06212.x. PubMed: 20586862.
16. Shiotani A, Nishi R, Yamanaka Y, Murao T, Matsumoto H et al. (2011) Renin-angiotensin system associated with risk of upper GI mucosal injury induced by low dose aspirin: renin angiotensin system genes' polymorphism. Dig Dis Sci 56: 465-471. doi:10.1007/s10620-010-1382-3. PubMed: 20824505.
17. Shiotani A, Murao T, Sakakibara T, Tarumi K, Manabe N et al. (2012) Association of SLCO1B1 1b with peptic ulcer amongst Japanese patients taking low-dose aspirin. Dig Liver Dis 44: 201-205. doi:10.1016/S1590-8658(12)60571-4. PubMed: 22088425.
18. van Oijen MG, Laheij RJ, Koetsier M, de Kleine E, Te Morsche RH et al. (2006) Effect of a specific cyclooxygenase-gene polymorphism (A-842G/C50T) on the occurrence of peptic ulcer hemorrhage. Dig Dis Sci 51: 2348-2352. doi:10.1007/s10620-006-9475-8. PubMed: 17078001.
19. Guengerich FP, Wu ZL, Bartleson CJ (2005) Function of human cytochrome P450s: characterization of the orphans. Biochem Biophys Res Commun 338: 465-469. doi:10.1016/j.bbrc.2005.08.079. PubMed: 16126164.
20. Nebert DW, Russell DW (2002) Clinical importance of the cytochromes P450. Lancet 360: 1155-1162. doi:10.1016/S0140-6736(02)11203-7. PubMed: 12387968.
21. Kalsotra A, Turman CM, Kikuta Y, Strobel HW (2004) Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids. Toxicol Appl Pharmacol 199: 295-304. doi:10.1016/j.taap.2003.12.033. PubMed: 15364545.
22. Zanger UM, Raimundo S, Eichelbaum M (2004) Cytochrome P450 2D6: overview and update on pharmacology, genetics. Biochemistry - Naunyn Schmiedebergs Arch Pharmacol, 369: 23-37. doi:10.1007/s00210-003-0832-2.
23. Dagle JM, Fisher TJ, Haynes SE, Berends SK, Brophy PD et al. (2011) Cytochrome P450 (CYP2D6) genotype is associated with elevated systolic blood pressure in preterm infants after discharge from the neonatal intensive care unit. J Pediatr 159: 104-109. doi:10.1016/j.jpeds.2011.01.002. PubMed: 21353244.
24. Qin S, Shen L, Zhang A, Xie J, Shen W et al. (2008) Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China. Genomics, 92(3): 152-158. doi:10.1016/j.ygeno. 2008.05.004. PubMed: 18632250.
25. Wallace JL (1997) Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology, 112: 1000-1016. Available online at: doi:10.1053/gast.1997.v112.pm9041264. PubMed: 9041264
26. Reuter BK, Davies NM, Wallace JL (1997) Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation. Gastroenterology, 112(1): 109-117. doi:10.1016/S0016-5085(97)70225- 7. PubMed: 8978349.
27. Wax J, Clinger WA, Varner P, Bass P, Winder CV (1970) Relationship of the enterohepatic cycle to ulcerogenesis in the rat small bowel with flufenamic acid. Gastroenterology, 58: 772-780. PubMed: 5423889.
28. Kent TH, Cardelli RM, Stamler FW (1969) Small intestinal ulcers and intestinal flora in rats given indomethacin. Am J Pathol 54: 237-249. PubMed: 5765565.
29. Whittle BJ, László F, Evans SM, Moncada S (1995) Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin. Br J Pharmacol 116: 2286-2290. doi:10.1111/j.1476-5381.1995. tb15066.x. PubMed: 8564261.
30. Wallace JL, Syer S, Denou E, de Palma G, Vong L, et al. (2011) Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology 141:1314-1322, 1322 e1311-1315
31. Delaney JA, Opatrny L, Brophy JM, Suissa S. (2007) Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding. CMAJ 177: 347-351. PubMed: 17698822.
32. Derry S, Loke YK (2000) Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 321: 1183-1187. doi:10.1136/bmj.321. 7270.1183. PubMed: 11073508.