Expression and function of visfatin (Nampt), an adipokine-enzyme involved in inflammatory pathways of osteoarthritis

Arthritis Research and Therapy

Volumn 16, Issue 1, 2014, Pages

  Laiguillon, Marie Charlotte ^a   Houard, Xavier ^a   Bougault, Carole ^a   Gosset, Marjolaine ^b   Nourissat, Geoffroy ^a,c   Sautet, Alain ^c   Jacques, Claire ^a   Berenbaum, Francis ^a,d,e   Sellam, Jérémie ^a,d,e  

^a CENTRE DE RECHERCHE SAINT ANTOINE   (France)

^b and Plateforme d'Imagerie du Vivant   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^d HÔPITAL SAINT ANTOINE   (France)

^e Inflammation Immunopathology Biotherapy Department (DHU i2B)   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE;

ANIMAL; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL CULTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; INFLAMMATION; METABOLISM; MOUSE; OSTEOARTHRITIS; OSTEOBLAST; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INFLAMMATION; MICE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OSTEOARTHRITIS; OSTEOBLASTS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84893175638     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4467     Document Type: Article

References (42)

1. Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 2012, 64:1697-1707. 10.1002/art.34453, 3366018, 22392533.
2. Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol 2010, 6:625-635. 10.1038/nrrheum.2010.159, 20924410.
3. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 2011, 7:33-42. 10.1038/nrrheum.2010.196, 21119608.
4. Scanzello CR, Goldring SR. The role of synovitis in osteoarthritis pathogenesis. Bone 2012, 51:249-257. 10.1016/j.bone.2012.02.012, 3372675, 22387238.
5. Mahjoub M, Berenbaum F, Houard X. Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis. Osteoporos Int 2012, 8:S841-S846.
6. Goldring SR. Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis. Ther Adv Musculoskelet Dis 2012, 4:249-258. 10.1177/1759720X12437353, 3403248, 22859924.
7. Lories RJ, Luyten FP. The bone-cartilage unit in osteoarthritis. Nat Rev Rheumatol 2011, 7:43-49. 10.1038/nrrheum.2010.197, 21135881.
8. Mutabaruka MS, Aoulad Aissa M, Delalandre A, Lavigne M, Lajeunesse D. Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression. Arthritis Res Ther 2010, 12:R20. 10.1186/ar2925, 2875652, 20141628.
9. Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006, 6:772-783. 10.1038/nri1937, 16998510.
10. Gomez R, Conde J, Scotece M, Gomez-Reino JJ, Lago F, Gualillo O. What's new in our understanding of the role of adipokines in rheumatic diseases?. Nat Rev Rheumatol 2011, 7:528-536. 10.1038/nrrheum.2011.107, 21808287.
11. Gabay O, Berenbaum F. Adipokines in arthritis: new kids on the block. Curr Rheumatol Rev 2009, 5:226-232.
12. Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet 2011, 377:2115-2126. 10.1016/S0140-6736(11)60243-2, 21684382.
13. Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 1994, 14:1431-1437. 358498, 8289818.
14. Luk T, Malam Z, Marshall JC. Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity. J Leukoc Biol 2008, 83:804-816. 10.1189/jlb.0807581, 18252866.
15. Kitani T, Okuno S, Fujisawa H. Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor. FEBS Lett 2003, 544:74-78. 10.1016/S0014-5793(03)00476-9, 12782293.
16. Brentano F, Schorr O, Ospelt C, Stanczyk J, Gay RE, Gay S, Kyburz D. Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities. Arthritis Rheum 2007, 56:2829-2839. 10.1002/art.22833, 17763446.
17. Gosset M, Berenbaum F, Salvat C, Sautet A, Pigenet A, Tahiri K, Jacques C. Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. Arthritis Rheum 2008, 58:1399-1409. 10.1002/art.23431, 18438860.
18. Moschen AR, Kaser A, Enrich B, Mosheimer B, Theurl M, Niederegger H, Tilg H. Visfatin, an adipocytokine with proinflammatory and immunomodulating properties. J Immunol 2007, 178:1748-1758.
19. Wang T, Zhang X, Bheda P, Revollo JR, Imai S, Wolberger C. Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. Nat Struct Mol Biol 2006, 13:661-662. 10.1038/nsmb1114, 16783373.
20. Ziegler M. New functions of a long-known molecule. Emerging roles of NAD in cellular signaling. Eur J Biochem 2000, 267:1550-1564. 10.1046/j.1432-1327.2000.01187.x, 10712584.
21. Khan JA, Tao X, Tong L. Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat Struct Mol Biol 2006, 13:582-588. 10.1038/nsmb1105, 16783377.
22. Wosikowski K, Mattern K, Schemainda I, Hasmann M, Rattel B, Loser R. WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells. Cancer Res 2002, 62:1057-1062.
23. Hasmann M, Schemainda I. FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res 2003, 63:7436-7442.
24. Busso N, Karababa M, Nobile M, Rolaz A, Van Gool F, Galli M, Leo O, So A, De Smedt T. Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD. PLoS One 2008, 3:e2267. 10.1371/journal.pone.0002267, 2377336, 18493620.
25. Otero M, Lago R, Gomez R, Lago F, Dieguez C, Gomez-Reino JJ, Gualillo O. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis 2006, 65:1198-1201. 10.1136/ard.2005.046540, 1798289, 16414972.
26. Meier FM, Frommer KW, Peters MA, Brentano F, Lefevre S, Schroder D, Kyburz D, Steinmeyer J, Rehart S, Gay S, Müller-Ladner U, Neumann E. Visfatin/pre-B-cell colony-enhancing factor (PBEF), a proinflammatory and cell motility-changing factor in rheumatoid arthritis. J Biol Chem 2012, 287:28378-28385. 10.1074/jbc.M111.312884, 3436531, 22767598.
27. Evans L, Williams AS, Hayes AJ, Jones SA, Nowell M. Selective inhibition of PBEF/Visfatin/NAMPT suppresses leukocyte infiltration and cartilage degradation. Arthritis Rheum 2011, 1002:30338.
28. Jacques C, Holzenberger M, Mladenovic Z, Salvat C, Pecchi E, Berenbaum F, Gosset M. Proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (Nampt) involve regulation of insulin signaling pathway and Nampt enzymatic activity. J Biol Chem 2012, 287:15100-15108. 10.1074/jbc.M112.350215, 3340217, 22399297.
29. Yammani RR, Loeser RF. Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes. Arthritis Res Ther 2012, 14:R23. 10.1186/ar3705, 3392816, 22289259.
30. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986, 29:1039-1049. 10.1002/art.1780290816, 3741515.
31. Chauffier K, Laiguillon MC, Bougault C, Gosset M, Priam S, Salvat C, Mladenovic Z, Nourissat G, Jacques C, Houard X, Berenbaum F, Sellam J. Induction of the chemokine IL-8/Kc by the articular cartilage: possible influence on osteoarthritis. Joint Bone Spine 2012, 79:604-609. 10.1016/j.jbspin.2011.12.013, 22342065.
32. Gosset M, Berenbaum F, Thirion S, Jacques C. Primary culture and phenotyping of murine chondrocytes. Nat Protoc 2008, 3:1253-1260. 10.1038/nprot.2008.95, 18714293.
33. Sanchez C, Gabay O, Salvat C, Henrotin YE, Berenbaum F. Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts. Osteoarthritis Cartilage 2009, 17:473-481. 10.1016/j.joca.2008.09.007, 18974013.
34. Bakker A, Klein-Nulend J. Osteoblast isolation from murine calvariae and long bones. Methods Mol Med 2003, 80:19-28.
35. Blaise R, Mahjoub M, Salvat C, Barbe U, Brou C, Corvol MT, Savouret JF, Rannou F, Berenbaum F, Bausero P. Involvement of the Notch pathway in the regulation of matrix metalloproteinase 13 and the dedifferentiation of articular chondrocytes in murine cartilage. Arthritis Rheum 2009, 60:428-439. 10.1002/art.24250, 19180482.
36. Chen WP, Bao JP, Feng J, Hu PF, Shi ZL, Wu LD. Increased serum concentrations of visfatin and its production by different joint tissues in patients with osteoarthritis. Clin Chem Lab Med 2010, 48:1141-1145.
37. Klein-Wieringa IR, Kloppenburg M, Bastiaansen-Jenniskens YM, Yusuf E, Kwekkeboom JC, El-Bannoudi H, Nelissen RG, Zuurmond A, Stojanovic-Susulic V, Van Osch GJ, Toes RE, Ioan-Facsinay A. The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype. Ann Rheum Dis 2011, 70:851-857. 10.1136/ard.2010.140046, 21242232.
38. Duan Y, Hao D, Li M, Wu Z, Li D, Yang X, Qiu G. Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis. Rheumatol Int 2012, 32:985-990. 10.1007/s00296-010-1731-8, 21246369.
39. Imai S. The NAD World: a new systemic regulatory network for metabolism and aging-Sirt1, systemic NAD biosynthesis, and their importance. Cell Biochem Biophys 2009, 53:65-74. 10.1007/s12013-008-9041-4, 2734380, 19130305.
40. Korner A, Garten A, Bluher M, Tauscher R, Kratzsch J, Kiess W. Molecular characteristics of serum visfatin and differential detection by immunoassays. J Clin Endocrinol Metab 2007, 92:4783-4791. 10.1210/jc.2007-1304, 17878256.
41. Garten A, Petzold S, Barnikol-Oettler A, Korner A, Thasler WE, Kratzsch J, Kiess W, Gebhardt R. Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes. Biochem Biophys Res Commun 2010, 391:376-381. 10.1016/j.bbrc.2009.11.066, 19912992.
42. Romacho T, Azcutia V, Vazquez-Bella M, Matesanz N, Cercas E, Nevado J, Carraro R, Rodriguez-Manas L, Sanchez-Ferrer CF, Peiro C. Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity. Diabetologia 2009, 52:2455-2463. 10.1007/s00125-009-1509-2, 19727662.