Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics

Journal of Neuroscience

Volumn 34, Issue 5, 2014, Pages 1856-1867

  Solowska, Joanna M ^a   D'Rozario, Mitchell ^b   Jean, Daphney C ^a   Davidson, Michael W ^c   Marenda, Daniel R ^a,b   Baas, Peter W ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b DREXEL UNIVERSITY   (United States)

^c FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Axon; Degeneration; Hereditary spastic paraplegia; Microtubule; Spastin

Indexed keywords

COMPLEMENTARY DNA; MUTANT PROTEIN; NOCODAZOLE; SPASTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BRAIN CELL CULTURE; CONTROLLED STUDY; DEPOLYMERIZATION; DYNAMICS; FEMALE; FIBROBLAST CULTURE; GAIN OF FUNCTION MUTATION; GENETIC TRANSFECTION; HAPLOINSUFFICIENCY; MALE; MICROTUBULE; MICROTUBULE ASSEMBLY; MOTOR PERFORMANCE; NERVE FIBER GROWTH; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; TRANSGENIC DROSOPHILA; WESTERN BLOTTING;

AXON; DEGENERATION; HEREDITARY SPASTIC PARAPLEGIA; MICROTUBULE; SPASTIN;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELLS, CULTURED; CYSTEINE; DISEASE MODELS, ANIMAL; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HAPLOINSUFFICIENCY; HUMANS; LOCOMOTION; MALE; MICROTUBULES; MUTATION; NEURONS; NOCODAZOLE; RATS; SPASTIC PARAPLEGIA, HEREDITARY; TRANSFECTION; TUBULIN MODULATORS; TYROSINE;

EID: 84893131595     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3309-13.2014     Document Type: Article

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