Menstrual blood closely resembles the uterine immune micro-environment and is clearly distinct from peripheral blood

Human Reproduction

Volumn 29, Issue 2, 2014, Pages 303-314

  Van Der Molen, R G ^a   Schutten, J H F ^a   Van Cranenbroek, B ^a   Ter Meer, M ^a   Donckers, J ^a   Scholten, R R ^a   Van Der Heijden, O W H ^a   Spaanderman, M E A ^a,b   Joosten, I ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CD56; Endometrium; Menstrual blood; NK cells

Indexed keywords

CD16 ANTIGEN; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 2;

ADULT; ARTICLE; BLOOD; CELL POPULATION; CLINICAL ARTICLE; ENDOMETRIUM; FEMALE; FLOW CYTOMETRY; FUNCTIONAL STATUS; HUMAN; IMMUNOCOMPETENT CELL; MENSTRUAL BLOOD; MENSTRUAL CUP; MENSTRUATION; MONONUCLEAR CELL; MYOMETRIUM; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; REGULATORY T LYMPHOCYTE; SENSITIVITY AND SPECIFICITY; UTERUS;

CD56; ENDOMETRIUM; MENSTRUAL BLOOD; NK CELLS;

ADULT; AREA UNDER CURVE; BLOOD; ENDOMETRIUM; FEMALE; GRANZYMES; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-15; INTERLEUKIN-2; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES; MENSTRUATION; PHENOTYPE; ROC CURVE; UTERUS;

EID: 84893101839     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/det398     Document Type: Article

References (26)

1. Aladdin H, Ullum H, Dam Nielsen S, Espersen C, Mathiesen L, Katzenstein TL, Gerstoft J, Skinhoj P, Pedersen BK. Granulocyte colony-stimulating factor increases CD4+ T cell counts of human immunodeficiency virus-infected patients receiving stable, highly active antiretroviral therapy: Results from a randomized, placebo-controlled trial. J Infect Dis 2000;181:1148-1152.
2. Arnon TI, Markel G, Mandelboim O. Tumor and viral recognition by natural killer cells receptors. Semin Cancer Biol 2006;16:348-358.
3. Arruvito L, Sanz M, Banham AH, Fainboim L. Expansion of CD4+CD25+and FOXP3+ regulatory T cells during the follicular phase of the menstrual cycle: Implications for human reproduction. J Immunol 2007;178:2572-2578.
4. Bulmer JN, Williams PJ, Lash GE. Immune cells in the placental bed. Int J Dev Biol 2010;54:281-294.
5. Eriksson M, Meadows SK, Wira CR, Sentman CL. Unique phenotype of human uterine NK cells and their regulation by endogenous TGF-beta. J Leukoc Biol 2004;76:667-675.
6. Flynn L, Byrne B, Carton J, Kelehan P, O'Herlihy C, O'Farrelly C. Menstrual cycle dependent fluctuations in NK and T-lymphocyte subsets from non-pregnant human endometrium. Am J Reprod Immunol 2000; 43:209-217.
7. Givan AL, White HD, Stern JE, Colby E, Gosselin EJ, Guyre PM, Wira CR. Flow cytometric analysis of leukocytes in the human female reproductive tract: Comparison of fallopian tube, uterus, cervix, and vagina. Am J Reprod Immunol 1997;38:350-359.
8. Hanna J, MandelboimO.Whenkillers becomehelpers. Trends Immunol 2007; 28:201-206.
9. Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, Prus D, Cohen-Daniel L, Arnon TI, Manaster I. et al.: Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med 2006;12:1065-1074.
10. King A, Wellings V, Gardner L, Loke YW. Immunocytochemical characterization of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle. Hum Immunol 1989; 24:195-205.
11. Koks CA, Dunselman GA, de Goeij AF, Arends JW, Evers JL. Evaluation of a menstrual cup to collect shed endometrium for in vitro studies. Fertil Steril 1997;68:560-564.
12. Lee JY, Lee M, Lee SK. Role of endometrial immune cells in implantation. Clin Exp Reprod Med 2011;38:119-125.
13. Lukassen HG, Joosten I, Van Cranenbroek B, Van Lierop MJ, Bulten J, Braat DD, Van der Meer A. Hormonal stimulation for IVF treatment positively affects the CD56bright/CD56dim NK cell ratio of the endometrium during the window of implantation. Mol Hum Reprod 2004;10:513-520.
14. Manaster I, Mizrahi S, Goldman-Wohl D, Sela HY, Stern-Ginossar N, Lankry D, Gruda R, Hurwitz A, Bdolah Y, Haimov-Kochman R. et al.: Endometrial NK cells are special immature cells that await pregnancy. J Immunol 2008;181:1869-1876.
15. Moffett A, Loke C. Immunology of placentation in eutherian mammals. Nat Rev Immunol 2006;6:584-594.
16. Nagamatsu T, Schust DJ. The immunomodulatory roles of macrophages at the maternal-fetal interface. Reprod Sci 2010;17:209-218.
17. Ponnampalam AP, Weston GC, TrajstmanAC, Susil B, Rogers PA. Molecular classification of human endometrial cycle stages by transcriptional profiling. Mol Hum Reprod 2004;10:879-893.
18. Sabbaj S, Hel Z, Richter HE, Mestecky J, Goepfert PA. Menstrual blood as a potential source of endometrial derived CD3+ T cells. PLoSOne 2011; 6:e28894.
19. Saito S, Nishikawa K, Morii T, Narita N, Enomoto M, Ichijo M. Expression of activation antigens CD69, HLA-DR, interleukin-2 receptor-Alpha (IL-2R alpha) and IL-2R beta on T cells of human decidua at an early stage of pregnancy. Immunology 1992;75:710-712.
20. Salamonsen LA, Lathbury LJ. Endometrial leukocytes and menstruation.Hum Reprod Update 2000;6:16-27.
21. TilburgsT, Scherjon SA, Roelen DL, Claas FH. DecidualCD8+CD28-Tcells express CD103 but not perforin. Hum Immunol 2009;70:96-100.
22. Trundley A, Moffett A. Human uterine leukocytes and pregnancy. Tissue Antigens 2004;63:1-12.
23. van der Meer A, Lukassen HG, van Cranenbroek B, Weiss EH, Braat DD, van Lierop MJ, Joosten I. Soluble HLA-G promotes Th1-Type cytokine production by cytokine-Activated uterine and peripheral natural killer cells. Mol Hum Reprod 2007;13:123-133.
24. Vandermolen DT, Gu Y. Human endometrial expression of granulocyte colony-stimulating factor (G-CSF) and its receptor, stimulation of endometrial G-CSF production by interleukin-1 beta, and G-CSF inhibition of choriocarcinoma cell proliferation. Am J Reprod Immunol 1996;36:278-284.
25. Yang H, Qiu L, Chen G, Ye Z, Lu C, Lin Q. Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients. Fertil Steril 2008; 89:656-661.
26. Yeaman GR, Guyre PM, Fanger MW, Collins JE, White HD, Rathbun W, Orndorff KA, Gonzalez J, Stern JE, Wira CR. Unique CD8+ T cell-rich lymphoid aggregates in human uterine endometrium. J Leukoc Biol 1997; 61:427-435.