메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages

In situ gelation of PEG-PLGA-PEG hydrogels containing high loading of hydroxyapatite: In vitro and in vivo characteristics

Author keywords

bone morphological protein 2; hydroxyapatite; injectibility; thermosensitive hydrogel

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADATION; BONE; COPOLYMERS; DEGRADATION; GELATION; HYDROXYAPATITE; POLYETHYLENE GLYCOLS; PROTEINS;

EID: 84893086782     PISSN: 17486041     EISSN: 1748605X     Source Type: Journal    
DOI: 10.1088/1748-6041/9/1/015011     Document Type: Article
Times cited : (24)

References (36)
  • 2
    • 70350451421 scopus 로고    scopus 로고
    • Bone regeneration using an acellular extracellular matrix and bone marrow mesenchymal stem cells expressing Cbfal
    • 10.1271/bbb.90329
    • Dong S W, Ying D J, Duan X J, Xie Z, Yu Z J, Zhu C H, Yang B and Sun J S 2009 Bone regeneration using an acellular extracellular matrix and bone marrow mesenchymal stem cells expressing Cbfal Biosci. Biotechnol. Biochem. 73 2226-33
    • (2009) Biosci. Biotechnol. Biochem. , vol.73 , pp. 2226-2233
    • Dong, S.W.1    Ying, D.J.2    Duan, X.J.3    Xie, Z.4    Yu, Z.J.5    Zhu, C.H.6    Yang, B.7    Sun, J.S.8
  • 5
    • 76749088344 scopus 로고    scopus 로고
    • Reconstruction of goat tibial defects using an injectable tricalcium phosphate/chitosan in combination with autologous platelet plasma
    • 10.1016/j.biomaterials.2010.01.038 0142-9612
    • Bi L, Cheng W J, Fan H B and Pei G X 2010 Reconstruction of goat tibial defects using an injectable tricalcium phosphate/chitosan in combination with autologous platelet plasma Biomaterials 31 3201-11
    • (2010) Biomaterials , vol.31 , pp. 3201-3211
    • Bi, L.1    Cheng, W.J.2    Fan, H.B.3    Pei, G.X.4
  • 7
    • 16344395138 scopus 로고    scopus 로고
    • Caprolactonic poloxamer analog: PEG-PCL-PEG
    • DOI 10.1021/bm049347a
    • Hwang M J, Suh J M, Bae Y H, Kim S W and Jeong B 2005 Caprolactonic poloxamer analog: PEG-PCL-PEG Biomacromolecules 6 885-90 (Pubitemid 40467832)
    • (2005) Biomacromolecules , vol.6 , Issue.2 , pp. 885-890
    • Hwang, M.J.1    Suh, J.M.2    Bae, Y.H.3    Kim, S.W.4    Jeong, B.5
  • 9
    • 73349129378 scopus 로고    scopus 로고
    • Injectable biodegradable thermosensitive hydrogel composite for orthopedic tissue engineering. Part 1: Preparation and characterization of nanohydroxyapatite/poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) hydrogel nanocomposites
    • 10.1021/jp907974d 1089-5647 B
    • Fu S Z, Guo G, Gong C Y, Zeng S, Liang H, Luo F, Zhang X N, Zhao X, Wei Y Q and Qian Z Y 2009 Injectable biodegradable thermosensitive hydrogel composite for orthopedic tissue engineering. Part 1: preparation and characterization of nanohydroxyapatite/poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) hydrogel nanocomposites J. Phys. Chem. B 113 16518-25
    • (2009) J. Phys. Chem. , vol.113 , pp. 16518-16525
    • Fu, S.Z.1    Guo, G.2    Gong, C.Y.3    Zeng, S.4    Liang, H.5    Luo, F.6    Zhang, X.N.7    Zhao, X.8    Wei, Y.Q.9    Qian, Z.Y.10
  • 10
    • 77956190482 scopus 로고    scopus 로고
    • Injectable, dual cross-linkable polyphosphazene blend hydrogels
    • 10.1016/j.biomaterials.2010.07.029 0142-9612
    • Potta T, Chun C J and Song S C 2010 Injectable, dual cross-linkable polyphosphazene blend hydrogels Biomaterials 31 8107-20
    • (2010) Biomaterials , vol.31 , pp. 8107-8120
    • Potta, T.1    Chun, C.J.2    Song, S.C.3
  • 11
    • 38049052995 scopus 로고    scopus 로고
    • Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications
    • 10.1021/bm7006967
    • Nair L S, Starnes T, Ko J K and Laurencin C T 2007 Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications Biomacromolecules 8 3779-85
    • (2007) Biomacromolecules , vol.8 , pp. 3779-3785
    • Nair, L.S.1    Starnes, T.2    Ko, J.K.3    Laurencin, C.T.4
  • 12
    • 33748792019 scopus 로고    scopus 로고
    • Thermosensitive chitosan as an injectable carrier for local drug delivery
    • Bae J W, Go D H and Park K D 2006 Thermosensitive chitosan as an injectable carrier for local drug delivery Macromol. Res. 14 461-5 (Pubitemid 44407272)
    • (2006) Macromolecular Research , vol.14 , Issue.4 , pp. 461-465
    • Bae, J.W.1    Go, D.H.2    Park, K.D.3    Lee, S.J.4
  • 13
    • 33750989896 scopus 로고    scopus 로고
    • Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering
    • DOI 10.1016/j.biomaterials.2006.08.044, PII S0142961206007642
    • Crompton K E, Goud J D, Bellamkond R V, Gengenbach T R, Finkelstein D I, Horne M K and Forsythe J S 2007 Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering Biomaterials 28 441-9 (Pubitemid 44740107)
    • (2007) Biomaterials , vol.28 , Issue.3 , pp. 441-449
    • Crompton, K.E.1    Goud, J.D.2    Bellamkonda, R.V.3    Gengenbach, T.R.4    Finkelstein, D.I.5    Horne, M.K.6    Forsythe, J.S.7
  • 14
    • 0001182329 scopus 로고    scopus 로고
    • Synthesis and thermal properties of poly(ethylene glycol)-poly(e- caprolactone) copolymers
    • PII S0032386197004448
    • Bogdanov B, Vidts A, Bulcke A, Verbeeck R and Schacht E 1998 Synthesis and thermal properties of poly(ethylene glycol)-poly(ε-caprolactone) copolymers Polymer 39 1631-6 (Pubitemid 128397891)
    • (1998) Polymer , vol.39 , Issue.8-9 , pp. 1631-1636
    • Bogdanov, B.1    Vidts, A.2    Van Den Bulcke, A.3    Verbeeck, R.4    Schacht, E.5
  • 15
    • 84859378531 scopus 로고    scopus 로고
    • Injectable and thermosensitive PLGA-g-PEG hydrogels containing hydroxyapatite: Preparation, characterization and in vitro release behavior
    • 10.1088/1748-6041/7/2/024107 0955-7717 024107
    • Lin G, Cosimbescu L, Karin N J and Tarasevich B J 2012 Injectable and thermosensitive PLGA-g-PEG hydrogels containing hydroxyapatite: preparation, characterization and in vitro release behavior Biomed. Mater. 7 024107
    • (2012) Biomed. Mater. , vol.7
    • Lin, G.1    Cosimbescu, L.2    Karin, N.J.3    Tarasevich, B.J.4
  • 16
    • 31144433357 scopus 로고    scopus 로고
    • Sol-gel transition behavior of biodegradable three-arm and four-arm star-shaped PLGA-PEG block copolymer aqueous solution
    • DOI 10.1016/j.epsl.2005.10.035
    • Lee S J, Han B R, Park S Y, Han D K and Kim S C 2006 Sol-gel transition behavior of biodegradable three-arm and four-arm star-shaped PLGA-PEG block copolymer aqueous solution J. Polym. Sci. A: Polym. Chem. 44 888-99 (Pubitemid 43133427)
    • (2006) Journal of Polymer Science, Part A: Polymer Chemistry , vol.44 , Issue.2 , pp. 888-899
    • Lee, S.U.J.1    Han, B.O.R.2    Park, S.Y.3    Han, D.K.4    Kim, S.C.5
  • 17
    • 81855170177 scopus 로고    scopus 로고
    • Synthesis and characterization of injectable, thermosensitive, and biocompatible acellular bone matrix/poly(ethylene glycol)-poly (ε-caprolactone) -poly(ethylene glycol) hydrogel composite
    • 10.1002/jbm.a.33262 1097-4636 A
    • Ni P Y, Fan M, Qian Z Y, Luo J C, Gong C Y, Fu S Z, Shi S, Luo F and Yang Z M 2012 Synthesis and characterization of injectable, thermosensitive, and biocompatible acellular bone matrix/poly(ethylene glycol)-poly (ε-caprolactone) -poly(ethylene glycol) hydrogel composite J. Biomed. Mater. Res. A 100 171-9
    • (2012) J. Biomed. Mater. Res. , vol.100 , pp. 171-179
    • Ni, P.Y.1    Fan, M.2    Qian, Z.Y.3    Luo, J.C.4    Gong, C.Y.5    Fu, S.Z.6    Shi, S.7    Luo, F.8    Yang, Z.M.9
  • 18
    • 80255132955 scopus 로고    scopus 로고
    • Hydroxyapatite/polylactide biphasic combination scaffold loaded with dexamethasone for bone regeneration
    • 10.1002/jbm.a.33223 1097-4636 A
    • Son J S, Kim S G, Oh J S, Appleford M, Oh S, Ong J L and Lee K B 2011 Hydroxyapatite/polylactide biphasic combination scaffold loaded with dexamethasone for bone regeneration J. Biomed. Mater. Res. A 99 638-47
    • (2011) J. Biomed. Mater. Res. , vol.99 , pp. 638-647
    • Son, J.S.1    Kim, S.G.2    Oh, J.S.3    Appleford, M.4    Oh, S.5    Ong, J.L.6    Lee, K.B.7
  • 19
    • 33644934897 scopus 로고    scopus 로고
    • Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
    • 10.1016/j.biomaterials.2006.01.039 0142-9612
    • Rezwan K, Chen Q, Blaker J and Boccaccini A 2006 Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering Biomaterials 27 3413-31
    • (2006) Biomaterials , vol.27 , pp. 3413-3431
    • Rezwan, K.1    Chen, Q.2    Blaker, J.3    Boccaccini, A.4
  • 21
    • 3142544767 scopus 로고    scopus 로고
    • Shape retaining injectable hydrogels for minimally invasive bulking
    • DOI 10.1097/01.ju.0000130466.84214.f7
    • Thornton A J, Alsberg E, Hill E E and Mooney D J 2004 Shape retaining injectable hydrogels for minimally invasive bulking J. Urol. 172 763-8 (Pubitemid 38900257)
    • (2004) Journal of Urology , vol.172 , Issue.2 , pp. 763-768
    • Thornton, A.J.1    Alsberg, E.2    Hill, E.E.3    Mooney, D.J.4
  • 22
    • 33847790484 scopus 로고    scopus 로고
    • Osteogenic differentiation of rabbit mesenchymal stem cells in thermo-reversible hydrogel constructs containing hydroxyapatite and bone morphogenic protein-2 (BMP-2)
    • DOI 10.1016/j.biomaterials.2007.02.008, PII S0142961207001457
    • Na K, Kim S W, Sun B K, Woo D G, Yang H N, Chung H M and Park K H 2007 Osteogenic differentiation of rabbit mesenchymal stem cells in thermo-reversible hydrogel constructs containing hydroxyapatite and bone morphogenic protein-2 (BMP-2) Biomaterials 28 2631-7 (Pubitemid 46389528)
    • (2007) Biomaterials , vol.28 , Issue.16 , pp. 2631-2637
    • Na, K.1    Kim, S.W.2    Sun, B.K.3    Woo, D.G.4    Yang, H.N.5    Chung, H.M.6    Park, K.H.7
  • 23
    • 34247377772 scopus 로고    scopus 로고
    • A novel biomagnetic nanoparticle based on hydroxyapatite
    • DOI 10.1088/0957-4484/18/16/165601, PII S0957448407387308
    • Wu H C, Wang T W, Sun J S, Wang W H and Lin F H 2007 A novel biomagnetic nanoparticle based on hydroxyapatite Nanotechnology 18 165601 (Pubitemid 46631164)
    • (2007) Nanotechnology , vol.18 , Issue.16 , pp. 165601
    • Wu, H.-C.1    Wang, T.-W.2    Sun, J.-S.3    Wang, W.-H.4    Lin, F.-H.5
  • 24
    • 0033879697 scopus 로고    scopus 로고
    • In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof
    • 10.1002/(SICI)1097-4636(200005)50:2<171::AID-JBM11>3.0.CO;2-F 1097-4636
    • Jeong B, Bae Y H and Kim S W 2000 In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof J. Biomed. Mater. Res. 50 171-7
    • (2000) J. Biomed. Mater. Res. , vol.50 , pp. 171-177
    • Jeong, B.1    Bae, Y.H.2    Kim, S.W.3
  • 25
    • 77955571111 scopus 로고    scopus 로고
    • Biodegradability and biocompatibility of thermoreversible hydrogels formed from mixing a sol and a precipitate of block copolymers in water
    • 10.1021/bm100549q
    • Yu L, Zhang Z, Zhang H and Ding J 2010 Biodegradability and biocompatibility of thermoreversible hydrogels formed from mixing a sol and a precipitate of block copolymers in water Biomacromolecules 11 2169-78
    • (2010) Biomacromolecules , vol.11 , pp. 2169-2178
    • Yu, L.1    Zhang, Z.2    Zhang, H.3    Ding, J.4
  • 26
    • 38349186227 scopus 로고    scopus 로고
    • Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size
    • 10.1002/jbm.b.30896 1552-4973
    • Burguera E F, Xu H H and Sun L 2008 Injectable calcium phosphate cement: effects of powder-to-liquid ratio and needle size J. Biomed. Mater. Res. B: Appl. Biomater. 84 493-502
    • (2008) J. Biomed. Mater. Res. B: Appl. Biomater. , vol.84 , pp. 493-502
    • Burguera, E.F.1    Xu, H.H.2    Sun, L.3
  • 28
    • 84866743989 scopus 로고    scopus 로고
    • Effect of mixing ceramics with a thermosensitive biodegradable hydrogel as composite graft
    • 10.1016/j.compositesb.2012.04.057 1359-8368 B
    • Lai P L, Hong D W, Lin T Y, Chen L H, Chen W J and Chu I M 2012 Effect of mixing ceramics with a thermosensitive biodegradable hydrogel as composite graft Composites B 43 3088-95
    • (2012) Composites , vol.43 , pp. 3088-3095
    • Lai, P.L.1    Hong, D.W.2    Lin, T.Y.3    Chen, L.H.4    Chen, W.J.5    Chu, I.M.6
  • 29
    • 53549133106 scopus 로고    scopus 로고
    • In situ gelling hydrogels incorporating microparticles as drug delivery carriers for regenerative medicine
    • 10.1002/jps.21310
    • Hou Q, Chau D Y, Pratoomsoot C, Tighe P J, Dua H S, Shakesheff K M and Rose F R 2008 In situ gelling hydrogels incorporating microparticles as drug delivery carriers for regenerative medicine J. Pharm. Sci. 97 3972-80
    • (2008) J. Pharm. Sci. , vol.97 , pp. 3972-3980
    • Hou, Q.1    Chau, D.Y.2    Pratoomsoot, C.3    Tighe, P.J.4    Dua, H.S.5    Shakesheff, K.M.6    Rose, F.R.7
  • 31
    • 80054103147 scopus 로고    scopus 로고
    • In vitro evaluation of an injectable chitosan gel for sustained local delivery of BMP-2 for osteoblastic differentiation
    • 10.1002/jbm.b.31909 1552-4973
    • Kim S, Tsao H, Kang Y, Young D A, Sen M, Wenke J C and Yang Y 2011 In vitro evaluation of an injectable chitosan gel for sustained local delivery of BMP-2 for osteoblastic differentiation J. Biomed. Mater. Res. B: Appl. Biomater. 99 380-90
    • (2011) J. Biomed. Mater. Res. B: Appl. Biomater. , vol.99 , pp. 380-390
    • Kim, S.1    Tsao, H.2    Kang, Y.3    Young, D.A.4    Sen, M.5    Wenke, J.C.6    Yang, Y.7
  • 32
    • 78649552759 scopus 로고    scopus 로고
    • Injectable rhBMP-2-loaded chitosan hydrogel composite: Osteoinduction at ectopic site and in segmental long bone defect
    • 10.1002/jbm.a.32957 1097-4636 A
    • Luca L, Rougemont A L, Walpoth B H, Boure L, Tami A, Anderson J M, Jordan O and Gurny R 2011 Injectable rhBMP-2-loaded chitosan hydrogel composite: osteoinduction at ectopic site and in segmental long bone defect J. Biomed. Mater. Res. A 96 66-74
    • (2011) J. Biomed. Mater. Res. , vol.96 , pp. 66-74
    • Luca, L.1    Rougemont, A.L.2    Walpoth, B.H.3    Boure, L.4    Tami, A.5    Anderson, J.M.6    Jordan, O.7    Gurny, R.8
  • 33
    • 84868463422 scopus 로고    scopus 로고
    • Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment
    • 10.1016/j.biomaterials.2012.10.015 0142-9612
    • Kisiel M, Martino M M, Ventura M, Hubbell J A, Hilborn J and Ossipov D A 2013 Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment Biomaterials 34 704-12
    • (2013) Biomaterials , vol.34 , pp. 704-712
    • Kisiel, M.1    Martino, M.M.2    Ventura, M.3    Hubbell, J.A.4    Hilborn, J.5    Ossipov, D.A.6
  • 34
    • 84863099299 scopus 로고    scopus 로고
    • In vivo osteoinductivity of gelatin ß-tri-calcium phosphate sponge and bone morphogenetic protein-2 on an equine third metacarpal bone defect
    • 10.1016/j.rvsc.2011.12.002
    • Tsuzuki N, Otsuka K, Seo J, Yamada K, Haneda S, Furuoka H, Tabata Y and Sasaki N 2012 In vivo osteoinductivity of gelatin ß-tri-calcium phosphate sponge and bone morphogenetic protein-2 on an equine third metacarpal bone defect Res. Vet. Sci. 93 1021-5
    • (2012) Res. Vet. Sci. , vol.93 , pp. 1021-1025
    • Tsuzuki, N.1    Otsuka, K.2    Seo, J.3    Yamada, K.4    Haneda, S.5    Furuoka, H.6    Tabata, Y.7    Sasaki, N.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.