Penetration studies of an extremely lipophilic active model substance from an oil-in-water emulsion: Influence of the lipophilicity of the formulation in human skin-part 2

Skin Pharmacology and Physiology

Volumn 27, Issue 2, 2014, Pages 97-105

  Naumann, S ^a,b   Lange, S ^c   Polak, G ^d   Kalhoelfer, V ^e   Motlagh, L ^a   Goebel, A ^a   Wohlrab, J ^b   Neubert, R H H ^a  

^a Institute of Pharmacy   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c SYMRISE AG   (Germany)

^d EVONIK INDUSTRIES AG   (Germany)

^e Induchem AG   (Switzerland)

Author keywords

Gas chromatography coupled with mass spectrometry; High performance liquid chromatography with ultraviolet detection; Human skin penetration; Lipophilic drug; Myritol PC; Oil in water emulsion; Salicyloyl phytosphingosine; Solvent drag; Vehicle lipophilicity

Indexed keywords

COSMETIC; DIHYDROAVENANTHRAMIDE D; GLYCYRRHIZIC ACID; PENETRATION ENHANCING AGENT; PHYTOSPHINGOSINE; PROPYLENE GLYCOL DICAPRYLATE; SALICYLOYL PHYTOSPHINGOSINE; UNCLASSIFIED DRUG; WATER OIL CREAM; MYRISTIC ACID ISOPROPYL ESTER; OLEIC ACID;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DERMIS; DRUG FORMULATION; DRUG PENETRATION; EPIDERMIS; EX VIVO STUDY; FRANZ DIFFUSION CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIPID PHASE; LIPOPHILICITY; MASS FRAGMENTOGRAPHY; PHYSICAL PHASE; PRIORITY JOURNAL; SKIN PENETRATION; STRATUM CORNEUM; THERMODYNAMICS; ULTRAVIOLET RADIATION; EMULSION; MEMBRANE FILTER; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; POLARIZATION MICROSCOPY; SKIN SURFACE; SOLUBILITY; THICKNESS;

CAPRYLATES; CHEMISTRY, PHARMACEUTICAL; EMULSIONS; HUMANS; SKIN; SKIN ABSORPTION; SPHINGOSINE; WATER;

EID: 84893055581     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000352077     Document Type: Article

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