Salicyloyl-phytosphingosine: A novel agent for the repair of photoaged skin

International Journal of Cosmetic Science

Volumn 29, Issue 4, 2007, Pages 319-329

  Farwick, M ^a   Watson, R E B ^b   Rawlings, A V ^c   Wollenweber, U ^a   Lersch, P ^a   Bowden, J J ^b   Bastrilles, J Y ^b   Griffiths, C E M ^b  

^a EVONIK INDUSTRIES AG   (Germany)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c AVR Consulting Ltd   (United Kingdom)

Author keywords

Anti ageing; Ceramide; Collagen; Fibrillin; Matrix metalloproteinase

Indexed keywords

BIOLOGICAL MARKER; CERAMIDE DERIVATIVE; DRUG VEHICLE; FIBRILLIN 1; INTERSTITIAL COLLAGENASE; METALLOPROTEINASE; PHYTOSPHINGOSINE; PLACEBO; PROCOLLAGEN; RETINOIC ACID; SALICYLIC ACID; SALICYLOYLPHYTOSPHINGOSINE; SCLEROPROTEIN; SPHINGOLIPID; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; WATER OIL CREAM;

ADULT; AGED; BASEMENT MEMBRANE; BIOPSY; CLINICAL ARTICLE; CLINICAL STUDY; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME SYNTHESIS; FACE; FEMALE; FIBROBLAST; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; PATCH TEST; PHOTOAGING; SKIN; WRINKLE;

EID: 34547115201     PISSN: 01425463     EISSN: 14682494     Source Type: Journal    
DOI: 10.1111/j.1467-2494.2007.00394.x     Document Type: Conference Paper

References (34)

1. Griffiths, C.E.M. The clinical identification and quantification of photodamage. Br. J. Dermatol. 127, 37 42 (1992).
2. Smith, J.G., Davidson, E.A., Sams, W.M. Clark, R.D. Alterations in human dermal connective tissue with age and chronic sun exposure. J. Invest. Dermatol. 39, 347 350 (1962).
3. Warren, R., Gartstein, V., Kligman, A.M. et al. Age, sunlight and facial skin: a histological and quantitative study. J. Am. Acad. Dermatol. 25, 751 760 (1991).
4. Chen, V.L., Fleischmajer, R., Schwartz, E. et al. Immunohistochemistry of elastotic material in sun damaged skin. J. Invest. Dermatol. 87, 334 337 (1986).
5. Griffiths, C.E.M., Russman, A.N., Majmudar, G. et al. Restoration of collagen formation in photodamaged skin by tretinoin (retinoic acid). N. Eng. J. Med. 329, 530 535 (1993).
6. Talwar, H.S., Griffiths, C.E.M., Fisher, G.J. et al. Reduced type I and type III procollagens in photodamaged adult human skin. J. Invest. Dermatol. 105, 285 290 (1995).
7. Watson, R.E.B., Griffiths, C.E.M., Craven, N.M. et al. Fibrillin-rich microfibrils are reduced in photoaged skin: distribution at the dermal-epidermal junction. J. Invest. Dermatol. 112, 782 787 (1999).
8. Kadoya, K., Sasaki, T., Kostka, G. et al. Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis. Br. J. Dermatol. 153, 607 612 (2005).
9. Varani, J., Warner, R.L., Gharaee-Kermani, M. et al. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J. Invest. Dermatol. 114, 480 486 (2000).
10. Chung, J.H., Seo, J.Y., Choi, H.R. et al. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J. Invest. Dermatol. 117, 1218 1224 (2001).
11. Brennan, M., Bhatti, H., Nerusu, K.C. et al. Matrix metalloproteinase-1 is the major collagenolytic enzyme responsible for collagen damage in UV-irradiated human skin. Photochem. Photobiol. 78, 43 48 (2003).
12. Weiss, J.S., Ellis, C.N., Headington, J.T. et al. Topical tretinoin improves photoaged skin: a double-blind, vehicle-controlled study. J. Am. Acad. Dermatol. 159, 527 532 (1998).
13. Fisher, G.J., Esmann, J., Griffiths, C.E.M. et al. Cellular, immunological and biochemical characterization of topical retinoic acid-treated human skin. J. Invest. Dermatol. 96, 699 707 (1991).
14. Lateef, H., Stevens, M.J. Varani, J. All-trans-retinoic acid suppresses matrix metalloproteinase activity and increases collagen synthesis in diabetic human skin in organ culture. Am. J. Pathol. 165, 167 174 (2004).
15. Watson, R.E.B., Ratnayaka, J.A., Brooke, R.C.C. et al. Retinoic acid receptor alpha expression and cutaneous ageing. Mech. Age. Dev. 125, 465 473 (2005).
16. Rawlings, A.V. Trends in stratum corneum research & the management of dry skin conditions. Int. J. Cos. Sci. 25, 63 95 (2003).
17. Pillai, S., Cho, S., Mahajan, M. et al. Synergy between vitamin D precursor 25-hydroxyvitamin D & short chain ceramides on keratinocyte proliferation and differentiation. J. Invest. Dermatol. Symp. Proceed. 1, 39 43 (1996).
18. Grether-Beck, S., Krutmann, J., Weitemeyer, C. et al. Barrier Sphingoid bases & barrier ceramides induce differentiation in basal keratinocytes. Proceed. 23rd IFSCC. 167 172 (2004).
19. Farwick, M., Edens, L., Schmitz, G., Weitemeyer, C. Lersch, P. Claim identification for cosmetic active ingredients using DNA-chip technology. Proceed. 23rd IFSCC. 333 337 (2004).
20. Kim, S., Hong, I., Hwang, J.S. et al. Phytosphingosine stimulates the differentiation of human keratinocytes and inhibits TPA-induced inflammatory epidermal hyperplasia in hairless mouse skin. Mol. Med. 12, 17 24 (2006).
21. Grau, R., Punzon, C., Fresno, M. et al. Peroxisomal-proliferator- activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition if activator protein -1. Biochem. J. 395, 81 88 (2006).
22. Mayes, A., Kealaher, P., Rawlings, A.V. et al. Antiaging & skin condition benefits of PPARalpha activating molecules. IFSCC Congress. Poster 136 (2002).
23. Leveque, J.L., Saint-Leger, D. Salicylic acid and derivatives. In : Skin Moisturization (Leyden J. Rawlings A.V., eds), pp. 353 364. Marcel Dekker, New York, NY (2002).
24. Huang, C., Ma, W.Y., Haneberger, D. et al. Inhibition of ultraviolet B-induced activator protein-1 activity by aspirin in AP-1 luceriferase transgenic mice. J. Biol. Chem. 272, 26325 26331 (1997).
25. Watson, R.E.B., Craven, N.M., Kang, S. et al. A short term screening protocol, using fibrillin-1 as a receptor molecule for photoaging repair agents. J. Invest. Dermatol. 116, 672 678 (2001).
26. Piche, E., Hafne, H.M., Hoffman, J. Junger, M. FOITS (fast optical in vivo topometry of human skin): new approaches to 3-D surface structures of human skin. Biomed. Tech. (Berl.). 45, 317 322 (2000).
27. Rittie, L. Fisher, G.J. UV light induced signal cascades in skin aging. Age. Res. Rev. 1, 705 720 (2002).
28. Williams, M.L. Elias, P.M. Nature of skin fragility in patients receiving retinoids for systemic effect. Arch. Dermatol. 117, 611 619 (1981).
29. Humphries, J.D., Parry, E.J., Watson, R.E.B. et al. All-trans retinoic acid compromises desmosome expression in human epidermis. Br. J. Dermatol. 139, 577 584 (1998).
30. Haynes, S.L., Shuttleworth, C.A. Kielty, C.M. Keratinocytes express fibrillin and assemble microfibrils: implications for dermal matrix organization. Br. J. Dermatol. 137, 17 23 (1997).
31. Duplan-Perrat, F., Damour, O., Montrocher, C. et al. Keratinocytes influence the maturation and organization of elastin network in a skin equivalent. J. Invest. Dermatol. 114, 365 370 (2000).
32. Dzamba, B.J., Keene, D.R., Isogai, Z. et al. Assembly of epithelial cell fibrillins. J. Invest. Dermatol. 117, 1612 1620 (2001).
33. Marionnet, C., Pierrard, C., Vioux-Chagnoleau, C. et al. Interactions between fibroblasts & keratinocytes in morphogenesis of dermal epidermal junction in a model of reconstructed skin. J. Invest. Dermatol. 126, 971 979 (2006).
34. Fisher, G.J., Kang, S., Varani, J., Bata-Csorgo, Z., Wan, Y., Datta, S. Voorhees, J.J. Mechanisms of photoaging and chronological skin aging. Arch. Dermatol. 138, 1462 1470 (2002).