The influence of physico-chemical properties of homologous nicotinic acid esters on the permeability and maximum flux through an octanol membrane

International Journal of Pharmaceutics

Volumn 163, Issue 1-2, 1998, Pages 11-22

  Le, Vinh Hiep ^a   Lippold, Bernhard C ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Homologous esters; Maximum flux; Nicotinic acid esters; Partition coefficient; Permeability; Rate constant of transfer; Solubility; Three compartment model

Indexed keywords

NICOTINIC ACID BUTYL ESTER; NICOTINIC ACID ESTER; NICOTINIC ACID ETHYL ESTER; NICOTINIC ACID HEXYL ESTER; NICOTINIC ACID METHYL ESTER; NICOTINIC ACID OCTYL ESTER; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; COMPARTMENT MODEL; DRUG ABSORPTION; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TRANSPORT; HYDROPHILICITY; LIPOPHILICITY; PARTITION COEFFICIENT; PH; PRIORITY JOURNAL;

EID: 0032542790     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00286-X     Document Type: Article

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