Patient, virus, and treatment-related risk factors in pediatric adenovirus infection after stem cell transplantation: Results of a routine monitoring program

Biology of Blood and Marrow Transplantation

Volumn 20, Issue 2, 2014, Pages 250-256

  Mynarek, Martin ^a   Ganzenmueller, Tina ^a   Mueller Heine, Annika ^a   Mielke, Christopher ^a   Gonnermann, Andrea ^a   Beier, Rita ^a   Sauer, Martin ^a   Eiz Vesper, Britta ^a   Kohstall, Ute ^a   Sykora, Karl Walter ^a   Heim, Albert ^a   Maecker Kolhoff, Britta ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Human adenovirus; Pediatric transplantation; Stem cell transplantation; Surveillance strategy

Indexed keywords

CIDOFOVIR; RIBAVIRIN; VIRUS DNA;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIVIRAL THERAPY; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; FECES ANALYSIS; FEMALE; GENE DOSAGE; GRAFT RECIPIENT; GRAFT SURVIVAL; HOSPITALIZED CHILD; HUMAN; HUMAN ADENOVIRUS; HUMAN ADENOVIRUS INFECTION; INFECTION RISK; INFECTION SENSITIVITY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PATIENT MONITORING; PRESCHOOL CHILD; VIRUS DETECTION; VIRUS LOAD; VIRUS STRAIN; VIRUS TYPING;

HUMAN ADENOVIRUS; PEDIATRIC TRANSPLANTATION; STEM CELL TRANSPLANTATION; SURVEILLANCE STRATEGY;

ADENOVIRIDAE INFECTIONS; CHILD; FEMALE; GENOTYPE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84893045950     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2013.11.009     Document Type: Article

References (33)

1. Robin M., Marque-Juillet S., Scieux C., et al. Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcome. Haematologica 2007, 92:1254-1257.
2. Ganzenmueller T., Heim A. Adenoviral load diagnostics by quantitative polymerase chain reaction: techniques and application. Rev Med Virol 2012, 22:194-208.
3. Echavarria M. Adenoviruses in immunocompromised hosts. Clin Microbiol Rev 2008, 21:704-715.
4. Lion T., Kosulin K., Landlinger C., et al. Monitoring of adenovirus load in stool by real-time PCR permits early detection of impending invasive infection in patients after allogeneic stem cell transplantation. Leukemia 2010, 24:706-714.
5. Watson T., MacDonald D., Song X., et al. Risk factors for molecular detection of adenovirus in pediatric hematopoietic stem cell transplantation recipients. Biol Blood Marrow Transplant 2012, 18:1227-1234.
6. Feuchtinger T., Matthes-Martin S., Richard C., et al. Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol 2006, 134:64-76.
7. Lindemans C.A., Leen A.M., Boelens J.J. How I treat adenovirus in hematopoietic stem cell transplant recipients. Blood 2010, 116:5476-5485.
8. Chakrabarti S., Mautner V., Osman H., et al. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood 2002, 100:1619-1627.
9. Lee Y.J., Chung D., Xiao K., et al. Adenovirus viremia and disease: comparison of T cell-depleted and conventional hematopoietic stem cell transplantation recipients from a single institution. Biol Blood Marrow Transplant 2013, 19:387-392.
10. Lion T., Baumgartinger R., Watzinger F., et al. Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease. Blood 2003, 102:1114-1120.
11. Yusuf U., Hale G.A., Carr J., et al. Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients. Transplantation 2006, 81:1398-1404.
12. Kampmann B., Cubitt D., Walls T., et al. Improved outcome for children with disseminated adenoviral infection following allogeneic stem cell transplantation. Br J Haematol 2005, 130:595-603.
13. Schilham M.W., Claas E.C., van Zaane W., et al. High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation. Clin Infect Dis 2002, 35:526-532.
14. Leruez-Ville M., Chardin-Ouachee M., Neven B., et al. Description of an adenovirus A31 outbreak in a paediatric haematology unit. Bone Marrow Transplant 2006, 38:23-28.
15. Mattner F., Sykora K.W., Meissner B., Heim A. An adenovirus type F41 outbreak in a pediatric bone marrow transplant unit: analysis of clinical impact and preventive strategies. Pediatr Infect Dis J 2008, 27:419-424.
16. Garnett C.T., Talekar G., Mahr J.A., et al. Latent species C adenoviruses in human tonsil tissues. JVirol 2009, 83:2417-2428.
17. Echavarria M.S., Ray S.C., Ambinder R., et al. PCR detection of adenovirus in a bone marrow transplant recipient: hemorrhagic cystitis as a presenting manifestation of disseminated disease. JClin Microbiol 1999, 37:686-689.
18. Williams K.M., Agwu A.L., Dabb A.A., et al. Aclinical algorithm identifies high risk pediatric oncology and bone marrow transplant patients likely to benefit from treatment of adenoviral infection. JPediatr Hematol Oncol 2009, 31:825-831.
19. Bhadri V.A., Lee-Horn L., Shaw P.J. Safety and tolerability of cidofovir in high-risk pediatric patients. Transpl Infect Dis 2009, 11:373-379.
20. Feuchtinger T., Lucke J., Hamprecht K., et al. Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation. Br J Haematol 2005, 128:503-509.
21. Feuchtinger T., Lang P., Handgretinger R. Adenovirus infection after allogeneic stem cell transplantation. Leuk Lymphoma 2007, 48:244-255.
22. Taniguchi K., Yoshihara S., Tamaki H., et al. Incidence and treatment strategy for disseminated adenovirus disease after haploidentical stem cell transplantation. Ann Hematol 2012, 91:1305-1312.
23. Copelan E., Casper J.T., Carter S.L., et al. Ascheme for defining cause of death and its application in the T cell depletion trial. Biol Blood Marrow Transplant 2007, 13:1469-1476.
24. Heim A., Ebnet C., Harste G., Pring-Akerblom P. Rapid and quantitative detection of human adenovirus DNA by real-time PCR. JMed Virol 2003, 70:228-239.
25. Henke-Gendo C., Ganzenmueller T., Kluba J., et al. Improved quantitative PCR protocols for adenovirus and CMV with an internal inhibition control system and automated nucleic acid isolation. JMed Virol 2012, 84:890-896.
26. Madisch I., Wolfel R., Harste G., Pommer H., Heim A. Molecular identification of adenovirus sequences: a rapid scheme for early typing of human adenoviruses in diagnostic samples of immunocompetent and immunodeficient patients. JMed Virol 2006, 78:1210-1217.
27. Gustafson I., Lindblom A., Yun Z., et al. Quantification of adenovirus DNA in unrelated donor hematopoietic stem cell transplant recipients. JClin Virol 2008, 43:79-85.
28. Walls T., Hawrami K., Shingadia D., et al. Polymerase chain reaction in the management of disseminated adenovirus infection after stem cell transplantation. Pediatr Infect Dis J 2004, 23:1167-1169.
29. George D., El-Mallawany N.K., Jin Z., et al. Adenovirus infection in paediatric allogeneic stem cell transplantation recipients is a major independent factor for significantly increasing the risk of treatment related mortality. Br J Haematol 2012, 156:99-108.
30. Garnett C.T., Erdman D., Xu W., Gooding L.R. Prevalence and quantitation of species C adenovirus DNA in human mucosal lymphocytes. JVirol 2002, 76:10608-10616.
31. Cooper R.J., Hallett R., Tullo A.B., Klapper P.E. The epidemiology of adenovirus infections in Greater Manchester, UK 1982-96. Epidemiol Infect 2000, 125:333-345.
32. Mandelboim M., Dror P., Azar R., et al. Adenovirus infections in hospitalized patients in Israel: epidemiology and molecular characterization. JClin Microbiol 2011, 49:597-601.
33. Hiwarkar P., Gaspar H.B., Gilmour K., et al. Impact of viral reactivations in the era of pre-emptive antiviral drug therapy following allogeneic haematopoietic SCT in paediatric recipients. Bone Marrow Transplant 2013, 48:803-808.