An adenovirus type F41 outbreak in a pediatric bone marrow transplant unit: analysis of clinical impact and preventive strategies

Pediatric Infectious Disease Journal

Volumn 27, Issue 5, 2008, Pages 419-424

  Mattner, Frauke ^a   Sykora, Karl Walter ^b   Meissner, Barbara ^b   Heim, Albert ^b  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

adenovirus type 41; BMT; molecular typing; outbreak

Indexed keywords

CIDOFOVIR; RIBAVIRIN; ANTIVIRUS AGENT; CAPSID PROTEIN; CYTOSINE; DRUG DERIVATIVE; HEXON CAPSID PROTEIN, ADENOVIRUS; PHOSPHONIC ACID DERIVATIVE; VIRUS DNA;

ADENOVIRUS; ADENOVIRUS F41; ADENOVIRUS INFECTION; ADOLESCENT; ARTICLE; BONE MARROW TRANSPLANTATION; CHILD; CLINICAL ARTICLE; DIARRHEA; EPIDEMIC; GENE SEQUENCE; HOSPITAL DEPARTMENT; HUMAN; MOLECULAR TYPING; PRIORITY JOURNAL; VIRUS DETECTION; VIRUS GENE; VIRUS TYPING; VOMITING; BLOOD; CHEMISTRY; CLASSIFICATION; CROSS INFECTION; DNA SEQUENCE; FECES; GASTROENTERITIS; GENETICS; GENOTYPE; GERMANY; INFANT; ISOLATION AND PURIFICATION; PATHOPHYSIOLOGY; PRESCHOOL CHILD; VIREMIA; VIROLOGY; VIRUS HEPATITIS; VIRUS INFECTION; VIRUS LOAD; VIRUS SHEDDING;

ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ADOLESCENT; ANTIVIRAL AGENTS; BLOOD; BONE MARROW TRANSPLANTATION; CAPSID PROTEINS; CHILD; CHILD, PRESCHOOL; CROSS INFECTION; CYTOSINE; DISEASE OUTBREAKS; DNA, VIRAL; FECES; GASTROENTERITIS; GENOTYPE; GERMANY; HEPATITIS, VIRAL, HUMAN; HUMANS; INFANT; PHOSPHONIC ACIDS; SEQUENCE ANALYSIS, DNA; VIRAL LOAD; VIREMIA; VIRUS SHEDDING;

EID: 45849144091     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e3181658c46     Document Type: Article

References (22)

1. Walls T, Shankar AG, Shingadia D. Adenovirus: an increasingly important pathogen in paediatric bone marrow transplant patients. Lancet Infect Dis. 2003;3:79-86.
2. Shields AF, Hackman RC, Fife KH, Corey L, Meyers JD. Adenovirus infections in patients undergoing bone-marrow transplantation. N Engl J Med. 1985;312:529 -533.
3. Howard DS, Phillips IG, Reece DE, et al. Adenovirus infections in hematopoietic stem cell transplant recipients. Clin Infect Dis. 1999;29: 1494-1501.
4. Baldwin A, Kingman H, Darville M, et al. Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation. Bone Marrow Transplant. 2000;26:1333-1338.
5. Chakrabarti S, Mautner V, Osman H, et al. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood. 2002;100:1619 -1627.
6. Seidemann K, Heim A, Pfister ED, et al. Monitoring of adenovirus infection in pediatric transplant recipients by quantitative PCR: report of six cases and review of the literature. Am J Transplant. 2004;4:2102-2108.
7. Kampmann B, Cubitt D, Walls T, et al. Improved outcome for childrenwith disseminated adenoviral infection following allogeneic stem cell transplantation. Br J Haematol. 2005;130:595- 603.
8. Leen AM, Rooney CM. Adenovirus as an emerging pathogen in immunocompromised patients. Br J Haematol. 2005;128:135-144.
9. Madisch I, Wolfel R, Harste G, Pommer H, Heim A. Molecular identification of adenovirus sequences: a rapid scheme for early typing of human adenoviruses in diagnostic samples of immunocompetent and immunodeficient patients. J Med Virol. 2006;78:1210 -1217.
10. Swenson PD, Wadell G, Allard A, Hierholzer JC. In: Murray PR, Baron EJ, Pfaller MA, Jorgensen JH, Yolken RA, eds. Manual of Clinical Microbiology. Vol. 2. Washington, DC: ASM Press; 2003:1404 -1417.
11. Lion T, Baumgartinger R, Watzinger F, et al. Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease. Blood. 2003;102: 1114-1120.
12. Slatter MA, Read S, Taylor CE, et al. Adenovirus type F subtype 41causing disseminated disease following bone marrow transplantation for immunodeficiency. J Clin Microbiol. 2005;43:1462-1464.
13. Garnett CT, Erdman D, Xu W, Gooding LR. Prevalence and quantitation of species C adenovirus DNA in human mucosal lymphocytes. J Virol. 2002;76:10608 -10616.
14. Leruez-Ville M, Chardin-Ouachee M, Neven B, et al. Description of an adenovirus A31 outbreak in a paediatric haematology unit. Bone Marrow Transplant. 2006;38:23-28.
15. Heim A, Ebnet C, Harste G, Pring-Akerblom P. Rapid and quantitative detection of human adenovirus DNA by real-time PCR. J Med Virol. 2003;70:228 -239.
16. Allard A, Albinsson B, Wadell G. Rapid typing of human adenoviruses by a general PCR combined with restriction endonuclease analysis. J Clin Microbiol. 2001;39:498 -505.
17. Sauerbrei A, Sehr K, Brandstadt A, Heim A, Reimer K, Wutzler P. Sensitivity of human adenoviruses to different groups of chemical biocides. J Hosp Infect. 2004;57:59-66.
18. Filho EP, da Costa Faria NR, Fialho AM, et al. Adenoviruses associated with acute gastroenteritis in hospitalized and community children up to 5 years old in Rio de Janeiro and Salvador, Brazil. J Med Microbiol. 2007;56(Pt 3):313-319.
19. Bordigoni P, Carret AS, Venard V, Witz F, Le Faou A. Treatment of adenovirus infections in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 2001;32:1290 -1297.
20. Venard V, Carret A, Corsaro D, Bordigoni P, Le Faou A. Genotyping of adenoviruses isolated in an outbreak in a bone marrow transplant unit shows that diverse strains are involved. J Hosp Infect 2000;44:71-74.
21. Wutzler P, Sauerbrei A. Virucidal efficacy of a combination of 0.2% peracetic acid and 80% (v/v) ethanol (PAA-ethanol) as a potential hand disinfectant. J Hosp Infect. 2000;46:304 -308.
22. Kampf G, Rudolf M, Labadie JC, Barrett SP. Spectrum of antimicrobial activity and user acceptability of the hand disinfectant agent Sterillium Gel. J Hosp Infect. 2002;52:141-147.