Antibiotic resistance in human chronic periodontitis microbiota

Journal of Periodontology

Volumn 85, Issue 1, 2014, Pages 160-169

  Rams, Thomas E ^a,b,c   Degener, John E ^c   Van Winkelhoff, Arie J ^c  

^a TEMPLE UNIVERSITY   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Anti infective agents; Chronic periodontitis; Drug resistance; In vitro; Periodontal pocket

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; CIPROFLOXACIN; CLINDAMYCIN; DOXYCYCLINE; METRONIDAZOLE;

ADULT; AGED; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL LOAD; CANDIDA; CHRONIC PERIODONTITIS; DRUG EFFECT; ENTEROCOCCUS FAECALIS; FEMALE; FUSOBACTERIUM NUCLEATUM; HUMAN; MALE; MICROBIOLOGY; MIDDLE AGED; PERIODONTAL POCKET; PREVOTELLA INTERMEDIA; PREVOTELLA NIGRESCENS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS CONSTELLATUS; TOOTH PLAQUE;

ADULT; AGED; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; AMOXICILLIN; ANTI-BACTERIAL AGENTS; BACTERIAL LOAD; CANDIDA; CHRONIC PERIODONTITIS; CIPROFLOXACIN; CLINDAMYCIN; DENTAL PLAQUE; DOXYCYCLINE; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS FAECALIS; FEMALE; FUSOBACTERIUM NUCLEATUM; HUMANS; MALE; METRONIDAZOLE; MIDDLE AGED; PERIODONTAL POCKET; PREVOTELLA INTERMEDIA; PREVOTELLA NIGRESCENS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS CONSTELLATUS;

EID: 84893035520     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2013.130142     Document Type: Article

References (49)

1. Slots J, Mashimo P, Levine MJ, Genco RJ. Periodontal therapy in humans. I. Microbiological and clinical effects of a single course of periodontal scaling and root planing, and of adjunctive tetracycline therapy. J Periodontol 1979;50:495-509.
2. Rams TE, Keyes PH, Wright WE, Howard SA. Longterm effects of microbiologically modulated periodontal therapy on advanced adult periodontitis. J Am Dent Assoc 1985;111:429-441.
3. Herrera D, Sanz M, Jepsen S, Needleman I, Roldán S. A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol 2002;29 (Suppl. 3):136-159.
4. Haffajee AD, Socransky SS, Gunsolley JC. Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol 2003;8:115-181.
5. Slots J; Research, Science and Therapy Committee. Systemic antibiotics in periodontics. J Periodontol 2004;75:1553-1565.
6. Sgolastra F, Petrucci A, Gatto R, Monaco A. Effectiveness of systemic amoxicillin/metronidazole as an adjunctive therapy to full-mouth scaling and root planing in the treatment of aggressive periodontitis: A systematic review and meta-analysis. J Periodontol 2012;83:731-743.
7. Sgolastra F, Gatto R, Petrucci A, Monaco A. Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: A systematic review and meta-analysis. J Periodontol 2012;83:1257-1269.
8. Goodson JM, Haffajee AD, Socransky SS, et al. Control of periodontal infections: A randomized controlled trial. I. The primary outcome attachment gain and pocket depth reduction at treated sites. J Clin Periodontol 2012;39:526-536.
9. Feres M, Soares GMS, Mendes JA, et al. Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: A 1-year doubleblinded, placebo-controlled, randomized clinical trial. J Clin Periodontol 2012;39:1149-1158.
10. Ellen RP, McCulloch CA. Evidence versus empiricism: Rational use of systemic antimicrobial agents for treatment of periodontitis. Periodontol 2000 1996; 10:29-44.
11. Mombelli A. Antimicrobial agents in periodontal prevention, therapy and maintenance: Conclusions from the GABA Forum, 6 December 2002, Lyon, France. Oral Dis 2003;9(Suppl. 1):71-72.
12. Veloo AC, Seme K, Raangs E, et al. Antibiotic susceptibility profiles of oral pathogens. Int J Antimicrob Agents 2012;40:450-454.
13. van Winkelhoff AJ, Herrera D, Oteo A, Sanz M. Antimicrobial profiles of periodontal pathogens isolated from periodontitis patients in The Netherlands and Spain. J Clin Periodontol 2005;32:893-898.
14. Ardila CM, Granada MI, Guzmán IC. Antibiotic resistance of subgingival species in chronic periodontitis patients. J Periodontal Res 2010;45:557-563.
15. Rams TE, Dujardin S, Sautter JD, Degener JE, van Winkelhoff AJ. Spiramycin resistance in human periodontitis microbiota. Anaerobe 2011;17:201-205.
16. Armitage GC. Periodontal diagnoses and classification of periodontal diseases. Periodontol 2000 2004;34: 9-21.
17. Möller ÅJ. Microbiological examination of root canals and periapical tissues of human teeth. Methodological studies. Odontol Tidskr 1966;74:1-380.
18. Dahlén G, Pipattanagovit P, Rosling B, Möller ÅJ. A comparison of two transport media for saliva and subgingival samples. Oral Microbiol Immunol 1993; 8:375-382.
19. Rauch CA, Nichols JH. Laboratory accreditation and inspection. Clin Lab Med 2007;27:845-858.
20. Slots J, Rams TE, Listgarten MA. Yeasts, enteric rods and pseudomonads in the subgingival flora of severe adult periodontitis. Oral Microbiol Immunol 1988;3: 47-52.
21. Slots J. Selective medium for isolation of Actinobacillus actinomycetemcomitans. J Clin Microbiol 1982;15:606-609.
22. Slots J. Rapid identification of important periodontal microorganisms by cultivation. Oral Microbiol Immunol 1986;1:48-57.
23. Rams TE, Listgarten MA, Slots J. Utility of 5 major putative periodontal pathogens and selected clinical parameters to predict periodontal breakdown in patients on maintenance care. J Clin Periodontol 1996; 23:346-354.
24. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing, Twenty-Second Informational Supplement, document M100-S22. Wayne, PA: Clinical and Laboratory Standards Institutes;2012:122-124.
25. Antibiogram Committee of the French Society of Microbiology. The Recommendations of the Antibiogram Committee, Recommendations 2010 (in French). Available at: http://www.sfm-microbiologie.org/UserFiles/file/CASFM/casfm-2010. pdf. Accessed April 1, 2013.
26. Feres M, Haffajee AD, Goncalves C, et al. Systemic doxycycline administration in the treatment of periodontal infections (II). Effect on antibiotic resistance of subgingival species. J Clin Periodontol 1999;26: 784-792.
27. van Winkelhoff AJ, Herrera Gonzales D, Winkel EG, Dellemijn-Kippuw N, Vandenbroucke-Grauls CM, Sanz M. Antimicrobial resistance in the subgingival microflora in patients with adult periodontitis. A comparison between The Netherlands and Spain. J Clin Periodontol 2000;27:79-86.
28. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard, 11th ed., document M02-A11. Wayne, PA: Clinical and Laboratory Standards Institute;2012.
29. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol 1998;25:134-144.
30. Rams TE, Degener JE, van Winkelhoff AJ. Antibiotic resistance in human peri-implantitis microbiota [published online ahead of print April 2, 2013]. Clin Oral Implants Res. doi:10.1111/clr.12160.
31. Listgarten MA, Lai CH, Young V. Microbial composition and pattern of antibiotic resistance in subgingival microbial samples from patients with refractory periodontitis. J Periodontol 1993;64:155-161.
32. Kleinfelder JW, Müller RF, Lange DE. Antibiotic susceptibility of putative periodontal pathogens in advanced periodontitis patients. J Clin Periodontol 1999;26:347-351.
33. Madinier IM, Fosse TB, Hitzig C, Charbit Y, Hannoun LR. Resistance profile survey of 50 periodontal strains of Actinobacillus actinomyectomcomitans. J Periodontol 1999;70:888-892.
34. Slots J, Evans RT, Lobbins PM, Genco RJ. In vitro antimicrobial susceptibility of Actinobacillus actinomycetemcomitans. Antimicrob Agents Chemother 1980;18:9-12.
35. Feres M, Haffajee AD, Allard K, Som S, Goodson JM, Socransky SS. Antibiotic resistance of subgingival species during and after antibiotic therapy. J Clin Periodontol 2002;29:724-735.
36. Rams TE, Degener JE, van Winkelhoff AJ. Prevalence of b-lactamase-producing bacteria in human periodontitis. J Periodont Res 2013;48:493-499.
37. Walker C, Gordon J. The effect of clindamycin on the microbiota associated with refractory periodontitis. J Periodontol 1990;61:692-698.
38. Winkel EG, Van Winkelhoff AJ, Timmerman MF, Van der Velden U, Van der Weijden GA. Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebocontrolled study. J Clin Periodontol 2001;28: 296-305.
39. Matarazzo F, Figueiredo LC, Cruz SE, Faveri M, Feres M. Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: A randomized placebo-controlled study. J Clin Periodontol 2008; 35:885-896.
40. Mestnik MJ, Feres M, Figueiredo LC, et al. The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: A 1-year double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol 2012;39:955-961.
41. Slots J, Feik D, Rams TE. Prevalence and antimicrobial susceptibility of Enterobacteriaceae, Pseudomonadaceae and Acinetobacter in human periodontitis. Oral Microbiol Immunol 1990;5:149-154.
42. Machtei EE, Christersson LA, Zambon JJ, et al. Alternative methods for screening periodontal disease in adults. J Clin Periodontol 1993;20:81-87.
43. Wade WG. The oral microbiome in health and disease. Pharmacol Res 2013;69:137-143.
44. Lewis MA, MacFarlane TW, McGowan DA. Reliability of sensitivity testing of primary culture of acute dentoalveolar abscess. Oral Microbiol Immunol 1988;3:177-180.
45. Stratton CW. In vitro susceptibility testing versus in vivo effectiveness. Med Clin North Am 2006;90:1077-1088.
46. Murray PR. Antimicrobial susceptibility tests: Testing methods and interpretive problems. In: Poupard JA, Walsh LR, Kleger B, eds. Antimicrobial Susceptibility Testing. New York: Plenum Press; 1994:15-25.
47. Fine DH. Microbial identification and antibiotic sensitivity testing, an aid for patients refractory to periodontal therapy. A report of 3 cases. J Clin Periodontol 1994;21:98-106.
48. Colombo AP, Haffajee AD, Dewhirst FE, et al. Clinical and microbiological features of refractory periodontitis subjects. J Clin Periodontol 1998;25:169-180.
49. Colombo AP, Teles RP, Torres MC, et al. Effects of nonsurgical mechanical therapy on the subgingival microbiota of Brazilians with untreated chronic periodontitis: 9-month results. J Periodontol 2005;76:778-784.