Structure, function and formation of glycans in Drosophila

Glycans: Biochemistry, Characterization and Applications

Volumn , Issue , 2012, Pages 165-188

  Yamamoto Hino, Miki ^a   Okano, Hideyuki ^a   Kanie, Osamu ^b   Goto, Satoshi ^a  

^a KEIO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84893022640     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (133)

1. Brooks SA. Strategies for analysis of the glycosylation of proteins: current status and future perspectives. Mol Biotechnol, 2009, 43(1), 76-88.
2. Aoki K, Perlman M, Lim JM, Cantu R, Wells L, Tiemeyer M. Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo. J Biol Chem, 2007, 282(12), 9127-9142.
3. Kanie Y, Yamamoto-Hino M, Karino Y, Yokozawa H, Nishihara S, Ueda R, et al. Insight into the regulation of glycan synthesis in Drosophila chaoptin based on mass spectrometry. PLoS One, 2009, 4(5), e5434.
4. North SJ, Koles K, Hembd C, Morris HR, Dell A, Panin VM, et al. Glycomic studies of Drosophila melanogaster embryos. Glycoconj J, 2006, 23(5-6), 345-354.
5. Yamamoto-Hino M, Kanie Y, Awano W, Aoki-Kinoshita KF, Yano H, Nishihara S, et al. Identification of genes required for neural-specific glycosylation using functional genomics. PLoS Genet, 2010, 6(12), e1001254.
6. Kim K, Lawrence SM, Park J, Pitts L, Vann WF, Betenbaugh MJ, et al. Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene: evidence for endogenous sialic acid biosynthetic ability in insects. Glycobiology, 2002, 12(2), 73-83.
7. Viswanathan K, Tomiya N, Park J, Singh S, Lee YC, Palter K, et al. Expression of a functional Drosophila melanogaster CMP-sialic acid synthetase. Differential localization of the Drosophila and human enzymes. J Biol Chem, 2006, 281(23), 15929-15940.
8. Koles K, Irvine KD, Panin VM. Functional characterization of Drosophila sialyltransferase. J Biol Chem, 2004, 279(6), 4346-4357.
9. Kurosaka A, Yano A, Itoh N, Kuroda Y, Nakagawa T, Kawasaki T. The structure of a neural specific carbohydrate epitope of horseradish peroxidase recognized by anti-horseradish peroxidase antiserum. J Biol Chem, 1991, 266(7), 4168-4172.
10. Jan LY, Jan YN. Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos. Proc Natl Acad Sci U S A, 1982, 79(8), 2700-2704.
11. Rendic D, Linder A, Paschinger K, Borth N, Wilson IB, Fabini G. Modulation of neural carbohydrate epitope expression in Drosophila melanogaster cells. J Biol Chem, 2006, 281(6), 3343-3353.
12. Hang HC, Bertozzi CR. The chemistry and biology of mucin-type O-linked glycosylation. Bioorg Med Chem, 2005, 13(17), 5021-5034.
13. Ten Hagen KG, Fritz TA, Tabak LA. All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases. Glycobiology, 2003, 13(1), 1R-16R.
14. Tian E, Ten Hagen KG. Recent insights into the biological roles of mucin-type O-glycosylation. Glycoconj J, 2009, 26(3), 325-334.
15. Breloy I, Schwientek T, Lehr S, Hanisch FG. Glucuronic acid can extend O-linked core 1 glycans, but it contributes only weakly to the negative surface charge of Drosophila melanogaster Schneider-2 cells. FEBS Lett, 2008, 582(11), 1593-1598.
16. Tian E, Ten Hagen KG. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Glycobiology, 2006, 16(2), 83-95.
17. Lin YR, Reddy BV, Irvine KD. Requirement for a core 1 galactosyltransferase in the Drosophila nervous system. Dev Dyn, 2008, 237(12), 3703-3714.
18. Ten Hagen KG, Tran DT, Gerken TA, Stein DS, Zhang Z. Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster. J Biol Chem, 2003, 278(37), 35039-35048.
19. Muller R, Hulsmeier AJ, Altmann F, Ten Hagen K, Tiemeyer M, Hennet T. Characterization of mucin-type core-1 beta1-3 galactosyltransferase homologous enzymes in Drosophila melanogaster. FEBS J, 2005, 272(17), 4295-4305.
20. Fredieu JR, Mahowald AP. Glycoconjugate expression during Drosophila embryogenesis. Acta Anat (Basel), 1994, 149(2), 89-99.
21. D'Amico P, Jacobs JR. Lectin histochemistry of the Drosophila embryo. Tissue Cell, 1995, 27(1), 23-30.
22. Tian E, Ten Hagen KG. O-linked glycan expression during Drosophila development. Glycobiology, 2007, 17(8), 820-827.
23. Yano H, Yamamoto-Hino M, Goto S. Spatial and temporal regulation of glycosylation during Drosophila eye development. Cell Tissue Res, 2009, 336(1), 137-147.
24. Xu A, Haines N, Dlugosz M, Rana NA, Takeuchi H, Haltiwanger RS, et al. In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe. J Biol Chem, 2007, 282(48), 35153-35162.
25. Stanley P. Regulation of Notch signaling by glycosylation. Curr Opin Struct Biol, 2007, 17(5), 530-535.
26. Luther KB, Haltiwanger RS. Role of unusual O-glycans in intercellular signaling. Int J Biochem Cell Biol, 2009, 41(5), 1011-1024.
27. Acar M, Jafar-Nejad H, Takeuchi H, Rajan A, Ibrani D, Rana NA, et al. Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell, 2008, 132(2), 247-258.
28. Wang Y, Shao L, Shi S, Harris RJ, Spellman MW, Stanley P, et al. Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. J Biol Chem, 2001, 276(43), 40338-40345.
29. Luo Y, Haltiwanger RS. O-fucosylation of notch occurs in the endoplasmic reticulum. J Biol Chem, 2005, 280(12), 11289-11294.
30. Okajima T, Xu A, Irvine KD. Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe. J Biol Chem, 2003, 278(43), 42340-42345.
31. Bruckner K, Perez L, Clausen H, Cohen S. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature, 2000, 406(6794), 411-415.
32. Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, Wilson R, et al. Fringe is a glycosyltransferase that modifies Notch. Nature, 2000, 406(6794), 369-375.
33. Hicks C, Johnston SH, diSibio G, Collazo A, Vogt TF, Weinmaster G. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat Cell Biol, 2000, 2(8), 515-520.
34. Munro S, Freeman M. The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD. Curr Biol, 2000, 10(14), 813-820.
35. Okajima T, Reddy B, Matsuda T, Irvine KD. Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling. BMC Biol, 2008, 6, 1.
36. Okajima T, Xu A, Lei L, Irvine KD. Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding. Science, 2005, 307(5715), 1599-1603.
37. Sasaki N, Sasamura T, Ishikawa HO, Kanai M, Ueda R, Saigo K, et al. Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells. Genes Cells, 2007, 12(1), 89-103.
38. Sasamura T, Ishikawa HO, Sasaki N, Higashi S, Kanai M, Nakao S, et al. The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila. Development, 2007, 134(7), 1347-1356.
39. Ishikawa HO, Higashi S, Ayukawa T, Sasamura T, Kitagawa M, Harigaya K, et al. Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc. Proc Natl Acad Sci U S A, 2005, 102(51), 18532-18537.
40. Ishikawa HO, Ayukawa T, Nakayama M, Higashi S, Kamiyama S, Nishihara S, et al. Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of Notch in Drosophila. J Biol Chem, 2010, 285(6), 4122-4129.
41. Goto S, Taniguchi M, Muraoka M, Toyoda H, Sado Y, Kawakita M, et al. UDP-sugar transporter implicated in glycosylation and processing of Notch. Nat Cell Biol, 2001, 3(9), 816-822.
42. Selva EM, Hong K, Baeg GH, Beverley SM, Turco SJ, Perrimon N, et al. Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events. Nat Cell Biol, 2001, 3(9), 809-815.
43. Yamada S, Okada Y, Ueno M, Iwata S, Deepa SS, Nishimura S, et al. Determination of the glycosaminoglycan-protein linkage region oligosaccharide structures of proteoglycans from Drosophila melanogaster and Caenorhabditis elegans. J Biol Chem, 2002, 277(35), 31877-31886.
44. Toyoda H, Kinoshita-Toyoda A, Fox B, Selleck SB. Structural analysis of glycosaminoglycans in animals bearing mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymes. J Biol Chem, 2000, 275(29), 21856-21861.
45. Toyoda H, Kinoshita-Toyoda A, Selleck SB. Structural analysis of glycosaminoglycans in Drosophila and Caenorhabditis elegans and demonstration that tout-velu, a Drosophila gene related to EXT tumor suppressors, affects heparan sulfate in vivo. J Biol Chem, 2000, 275(4), 2269-2275.
46. Lawrence R, Olson SK, Steele RE, Wang L, Warrior R, Cummings RD, et al. Evolutionary differences in glycosaminoglycan fine structure detected by quantitative glycan reductive isotope labeling. J Biol Chem, 2008, 283(48), 33674-33684.
47. Nakato H, Futch TA, Selleck SB. The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila. Development, 1995, 121(11), 3687-3702.
48. Khare N, Baumgartner S. Dally-like protein, a new Drosophila glypican with expression overlapping with wingless. Mech Dev, 2000, 99(1-2), 199-202.
49. Spring J, Paine-Saunders SE, Hynes RO, Bernfield M. Drosophila syndecan: conservation of a cell-surface heparan sulfate proteoglycan. Proc Natl Acad Sci U S A, 1994, 91(8), 3334-3338.
50. Datta S, Kankel DR. l(1)trol and l(1)devl, loci affecting the development of the adult central nervous system in Drosophila melanogaster. Genetics, 1992, 130(3), 523-537.
51. Martin-Blanco E, Garcia-Bellido A. Mutations in the rotated abdomen locus affect muscle development and reveal an intrinsic asymmetry in Drosophila. Proc Natl Acad Sci U S A, 1996, 93(12), 6048-6052.
52. Ichimiya T, Manya H, Ohmae Y, Yoshida H, Takahashi K, Ueda R, et al. The twisted abdomen phenotype of Drosophila POMT1 and POMT2 mutants coincides with their heterophilic protein O-mannosyltransferase activity. J Biol Chem, 2004, 279(41), 42638-42647.
53. Lyalin D, Koles K, Roosendaal SD, Repnikova E, Van Wechel L, Panin VM. The twisted gene encodes Drosophila protein O-mannosyltransferase 2 and genetically interacts with the rotated abdomen gene encoding Drosophila protein O-mannosyltransferase 1. Genetics, 2006, 172(1), 343-353.
54. Nakamura N, Stalnaker SH, Lyalin D, Lavrova O, Wells L, Panin VM. Drosophila Dystroglycan is a target of O-mannosyltransferase activity of two protein O-mannosyltransferases, Rotated Abdomen and Twisted. Glycobiology, 2010, 20(3), 381-394.
55. Willer T, Valero MC, Tanner W, Cruces J, Strahl S. O-mannosyl glycans: from yeast to novel associations with human disease. Curr Opin Struct Biol, 2003, 13(5), 621-630.
56. Webel R, Menon I, O'Tousa JE, Colley NJ. Role of asparagine-linked oligosaccharides in rhodopsin maturation and association with its molecular chaperone, NinaA. J Biol Chem, 2000, 275(32), 24752-24759.
57. Hirai-Fujita Y, Yamamoto-Hino M, Kanie O, Goto S. N-Glycosylation of the Drosophila neural protein Chaoptin is essential for its stability, cell surface transport and adhesive activity. FEBS Lett, 2008, 582(17), 2572-2576.
58. Leonard R, Rendic D, Rabouille C, Wilson IB, Preat T, Altmann F. The Drosophila fused lobes gene encodes an N-acetylglucosaminidase involved in N-glycan processing. J Biol Chem, 2006, 281(8), 4867-4875.
59. Boquet I, Hitier R, Dumas M, Chaminade M, Preat T. Central brain postembryonic development in Drosophila: implication of genes expressed at the interhemispheric junction. J Neurobiol, 2000, 42(1), 33-48.
60. Sarkar M, Leventis PA, Silvescu CI, Reinhold VN, Schachter H, Boulianne GL. Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span. J Biol Chem, 2006, 281(18), 12776-12785.
61. Repnikova E, Koles K, Nakamura M, Pitts J, Li H, Ambavane A, et al. Sialyltransferase regulates nervous system function in Drosophila. J Neurosci, 2010, 30(18), 6466-6476.
62. Katz F, Moats W, Jan YN. A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate). EMBO J, 1988, 7(11), 3471-3477.
63. Whitlock KE. Development of Drosophila wing sensory neurons in mutants with missing or modified cell surface molecules. Development, 1993, 117(4), 1251-1260.
64. Phillis RW, Bramlage AT, Wotus C, Whittaker A, Gramates LS, Seppala D, et al. Isolation of mutations affecting neural circuitry required for grooming behavior in Drosophila melanogaster. Genetics, 1993, 133(3), 581-592.
65. Brown NH. Null mutations in the alpha PS2 and beta PS integrin subunit genes have distinct phenotypes. Development, 1994, 120(5), 1221-1231.
66. Olofsson B, Page DT. Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity. Dev Biol, 2005, 279(1), 233-243.
67. Ruaud AF, Lam G, Thummel CS. The Drosophila nuclear receptors DHR3 and betaFTZ-F1 control overlapping developmental responses in late embryos. Development, 2010, 137(1), 123-131.
68. Ashraf SI, Ganguly A, Roote J, Ip YT. Worniu, a Snail family zinc-finger protein, is required for brain development in Drosophila. Dev Dyn, 2004, 231(2), 379-386.
69. Tian E, Ten Hagen KG. A UDP-GalNAc:polypeptide N-acetyl galactosaminyltransferase is required for epithelial tube formation. J Biol Chem, 2007, 282(1), 606-614.
70. Zhang L, Zhang Y, Hagen KG. A mucin-type O-glycosyltransferase modulates cell adhesion during Drosophila development. J Biol Chem, 2008, 283(49), 34076-34086.
71. Zhang L, Tran DT, Ten Hagen KG. An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand. J Biol Chem, 2010, 285(25), 19491-19501.
72. Zhang L, Ten Hagen KG. Dissecting the biological role of mucin-type O-glycosylation using RNA interference in Drosophila cell culture. J Biol Chem, 2010, 285(45), 34477-34484.
73. Fortini ME. Notch signaling: the core pathway and its posttranslational regulation. Dev Cell, 2009, 16(5), 633-647.
74. Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell, 2009, 137(2), 216-233.
75. Tien AC, Rajan A, Bellen HJ. A Notch updated. J Cell Biol, 2009, 184(5), 621-629.
76. Lawrence PA, Struhl G. Morphogens, compartments, and pattern: lessons from drosophila? Cell, 1996, 85(7), 951-961.
77. Tabata T, Takei Y. Morphogens, their identification and regulation. Development, 2004, 131(4), 703-712.
78. Takei Y, Ozawa Y, Sato M, Watanabe A, Tabata T. Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans. Development, 2004, 131(1), 73-82.
79. Bornemann DJ, Duncan JE, Staatz W, Selleck S, Warrior R. Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways. Development, 2004, 131(9), 1927-1938.
80. Han C, Belenkaya TY, Khodoun M, Tauchi M, Lin X. Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation. Development, 2004, 131(7), 1563-1575.
81. Tsuda M, Kamimura K, Nakato H, Archer M, Staatz W, Fox B, et al. The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila. Nature, 1999, 400(6741), 276-280.
82. Jackson SM, Nakato H, Sugiura M, Jannuzi A, Oakes R, Kaluza V, et al. dally, a Drosophila glypican, controls cellular responses to the TGF-beta-related morphogen, Dpp. Development, 1997, 124(20), 4113-4120.
83. Lin X, Perrimon N. Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling. Nature, 1999, 400(6741), 281-284.
84. Fujise M, Takeo S, Kamimura K, Matsuo T, Aigaki T, Izumi S, et al. Dally regulates Dpp morphogen gradient formation in the Drosophila wing. Development, 2003, 130(8), 1515-1522.
85. Belenkaya TY, Han C, Yan D, Opoka RJ, Khodoun M, Liu H, et al. Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans. Cell, 2004, 119(2), 231-244.
86. Han C, Belenkaya TY, Wang B, Lin X. Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process. Development, 2004, 131(3), 601-611.
87. Han C, Yan D, Belenkaya TY, Lin X. Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc. Development, 2005, 132(4), 667-679.
88. Kreuger J, Perez L, Giraldez AJ, Cohen SM. Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity. Dev Cell, 2004, 7(4), 503-512.
89. Franch-Marro X, Marchand O, Piddini E, Ricardo S, Alexandre C, Vincent JP. Glypicans shunt the Wingless signal between local signalling and further transport. Development, 2005, 132(4), 659-666.
90. Marois E, Mahmoud A, Eaton S. The endocytic pathway and formation of the Wingless morphogen gradient. Development, 2006, 133(2), 307-317.
91. Lin X, Buff EM, Perrimon N, Michelson AM. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development. Development, 1999, 126(17), 3715-3723.
92. Yan D, Lin X. Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis. Dev Biol, 2007, 312(1), 203-216.
93. Kamimura K, Koyama T, Habuchi H, Ueda R, Masu M, Kimata K, et al. Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling. J Cell Biol, 2006, 174(6), 773-778.
94. Johnson KG, Ghose A, Epstein E, Lincecum J, O'Connor MB, Van Vactor D. Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance. Curr Biol, 2004, 14(6), 499-504.
95. Steigemann P, Molitor A, Fellert S, Jackle H, Vorbruggen G. Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling. Curr Biol, 2004, 14(3), 225-230.
96. Fox AN, Zinn K. The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase. Curr Biol, 2005, 15(19), 1701-1711.
97. Rawson JM, Dimitroff B, Johnson KG, Ge X, Van Vactor D, Selleck SB. The heparan sulfate proteoglycans Dally-like and Syndecan have distinct functions in axon guidance and visual-system assembly in Drosophila. Curr Biol, 2005, 15(9), 833-838.
98. Johnson KG, Tenney AP, Ghose A, Duckworth AM, Higashi ME, Parfitt K, et al. The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development. Neuron, 2006, 49(4), 517-531.
99. Ren Y, Kirkpatrick CA, Rawson JM, Sun M, Selleck SB. Cell type-specific requirements for heparan sulfate biosynthesis at the Drosophila neuromuscular junction: effects on synapse function, membrane trafficking, and mitochondrial localization. J Neurosci, 2009, 29(26), 8539-8550.
100. Hayashi Y, Kobayashi S, Nakato H. Drosophila glypicans regulate the germline stem cell niche. J Cell Biol, 2009, 187(4), 473-480.
101. Guo Z, Wang Z. The glypican Dally is required in the niche for the maintenance of germline stem cells and short-range BMP signaling in the Drosophila ovary. Development, 2009, 136(21), 3627-3635.
102. Park Y, Rangel C, Reynolds MM, Caldwell MC, Johns M, Nayak M, et al. Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division. Dev Biol, 2003, 253(2), 247-257.
103. Lindner JR, Hillman PR, Barrett AL, Jackson MC, Perry TL, Park Y, et al. The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contexts. BMC Dev Biol, 2007, 7, 121.
104. Schneider M, Khalil AA, Poulton J, Castillejo-Lopez C, Egger-Adam D, Wodarz A, et al. Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization. Development, 2006, 133(19), 3805-3815.
105. Mirouse V, Christoforou CP, Fritsch C, St Johnston D, Ray RP. Dystroglycan and perlecan provide a basal cue required for epithelial polarity during energetic stress. Dev Cell, 2009, 16(1), 83-92.
106. Haines N, Seabrooke S, Stewart BA. Dystroglycan and protein O-mannosyltransferases 1 and 2 are required to maintain integrity of Drosophila larval muscles. Mol Biol Cell, 2007, 18(12), 4721-4730.
107. Skrincosky D, Kain R, El-Battari A, Exner M, Kerjaschki D, Fukuda M. Altered Golgi localization of core 2 beta-1, 6-N-acetylglucosaminyltransferase leads to decreased synthesis of branched O-glycans. J Biol Chem, 1997, 272(36), 22695-22702.
108. Kim J, Irvine KD, Carroll SB. Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing. Cell, 1995, 82(5), 795-802.
109. Panin VM, Papayannopoulos V, Wilson R, Irvine KD. Fringe modulates Notch-ligand interactions. Nature, 1997, 387(6636), 908-912.
110. Irvine KD, Wieschaus E. fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell, 1994, 79(4), 595-606.
111. Ten Hagen KG, Tran DT. A UDP-GalNAc:polypeptide N-acetylgal actosaminyltransferase is essential for viability in Drosophila melanogaster. J Biol Chem, 2002, 277(25), 22616-22622.
112. Rendic D, Sharrow M, Katoh T, Overcarsh B, Nguyen K, Kapurch J, et al. Neural-specific alpha3-fucosylation of N-linked glycans in the Drosophila embryo requires fucosyltransferase A and influences developmental signaling associated with O-glycosylation. Glycobiology, 2010, 20(11), 1353-1365.
113. McCormick C, Duncan G, Goutsos KT, Tufaro F. The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate. Proc Natl Acad Sci U S A, 2000, 97(2), 668-673.
114. Giraudo CG, Daniotti JL, Maccioni HJ. Physical and functional association of glycolipid N-acetyl-galactosaminyl and galactosyl transferases in the Golgi apparatus. Proc Natl Acad Sci U S A, 2001, 98(4), 1625-1630.
115. Giraudo CG, Maccioni HJ. Ganglioside glycosyltransferases organize in distinct multienzyme complexes in CHO-K1 cells. J Biol Chem, 2003, 278(41), 40262-40271.
116. Munro S. A comparison of the transmembrane domains of Golgi and plasma membrane proteins. Biochem Soc Trans, 1995, 23(3), 527-530.
117. Bretscher MS, Munro S. Cholesterol and the Golgi apparatus. Science, 1993, 261(5126), 1280-1281.
118. Munro S. Sequences within and adjacent to the transmembrane segment of alpha-2, 6-sialyltransferase specify Golgi retention. EMBO J, 1991, 10(12), 3577-3588.
119. Patterson GH, Hirschberg K, Polishchuk RS, Gerlich D, Phair RD, Lippincott-Schwartz J. Transport through the Golgi apparatus by rapid partitioning within a two-phase membrane system. Cell, 2008, 133(6), 1055-1067.
120. Okamoto M, Yoko-o T, Miyakawa T, Jigami Y. The cytoplasmic region of alpha-1, 6-mannosyltransferase Mnn9p is crucial for retrograde transport from the Golgi apparatus to the endoplasmic reticulum in Saccharomyces cerevisiae. Eukaryot Cell, 2008, 7(2), 310-318.
121. Uemura S, Yoshida S, Shishido F, Inokuchi J. The cytoplasmic tail of GM3 synthase defines its subcellular localization, stability, and in vivo activity. Mol Biol Cell, 2009, 20(13), 3088-3100.
122. Tu L, Tai WC, Chen L, Banfield DK. Signal-mediated dynamic retention of glycosyltransferases in the Golgi. Science, 2008, 321(5887), 404-407.
123. Schmitz KR, Liu J, Li S, Setty TG, Wood CS, Burd CG, et al. Golgi localization of glycosyltransferases requires a Vps74p oligomer. Dev Cell, 2008, 14(4), 523-534.
124. Foulquier F. COG defects, birth and rise! Biochim Biophys Acta, 2009, 1792(9), 896-902.
125. Seppo A, Matani P, Sharrow M, Tiemeyer M. Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells. Development, 2003, 130(7), 1439-1448.
126. Baas S, Sharrow M, Kotu V, Middleton M, Nguyen K, Flanagan-Steet H, et al. Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo. Development, 2011, 138(3), 553-563.
127. Gill DJ, Chia J, Senewiratne J, Bard F. Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymes. J Cell Biol, 2010, 189(5), 843-858.
128. Bard F, Mazelin L, Pechoux-Longin C, Malhotra V, Jurdic P. Src regulates Golgi structure and KDEL receptor-dependent retrograde transport to the endoplasmic reticulum. J Biol Chem, 2003, 278(47), 46601-46606.
129. Yeatman TJ. A renaissance for SRC. Nat Rev Cancer, 2004, 4(6), 470-480.
130. Brockhausen I. Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions. EMBO Rep, 2006, 7(6), 599-604.
131. Springer GF. T and Tn, general carcinoma autoantigens. Science, 1984, 224(4654), 1198-1206.
132. Yu LG, Andrews N, Zhao Q, McKean D, Williams JF, Connor LJ, et al. Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion. J Biol Chem, 2007, 282(1), 773-781.
133. Yano H, Yamamoto-Hino M, Abe M, Kuwahara R, Haraguchi S, Kusaka I, et al. Distinct functional units of the Golgi complex in Drosophila cells. Proc Natl Acad Sci U S A, 2005, 102(38), 13467-1347.