Rab GTPase prenylation hierarchy and its potential role in choroideremia disease

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Köhnke, Monika ^a   Delon, Christine ^c   Hastie, Marcus L ^b   Nguyen, Uyen T T ^a,d   Wu, Yao Wen ^c   Waldmann, Herbert ^c   Goody, Roger S ^c   Gorman, Jeffrey J ^b   Alexandrov, Kirill ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^d PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN RAB27B; PROTEIN RAB38; PROTEIN RAB42; RAB PROTEIN; RAB27A PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CHOROIDEREMIA; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; MEMBRANE TRANSPORT; PROTEIN PRENYLATION; PROTEIN PROCESSING;

CHOROIDEREMIA; ESCHERICHIA COLI; HUMANS; PRENYLATION; RAB GTP-BINDING PROTEINS; TIME FACTORS;

EID: 84893001781     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081758     Document Type: Article

References (38)

1. Stenmark H (2009) Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 10: 513-525. doi:10.1038/nrg2642. PubMed: 19603039.
2. Andres DA, Seabra MC, Brown MS, Armstrong SA, Smeland TE et al. (1993) cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein. Cell 73: 1091-1099. doi:10.1016/0092- 8674(93)90639-8. PubMed: 8513495. (Pubitemid 23180484)
3. Alexandrov K, Horiuchi H, Steele-Mortimer O, Seabra MC, Zerial M (1994) Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes. EMBO J 13: 5262-5273. PubMed: 7957092. (Pubitemid 24351804)
4. Rak A, Pylypenko O, Niculae A, Pyatkov K, Goody RS et al. (2004) Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell 117: 749-760. doi: 10.1016/j.cell.2004.05.017. PubMed: 15186776. (Pubitemid 38748891)
5. Nguyen UT, Goody RS, Alexandrov K (2010) Understanding and exploiting protein prenyltransferases. Chembiochem 11: 1194-1201. doi:10.1002/cbic. 200900727. PubMed: 20432425.
6. Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (1994) REP-2, a Rab escort protein encoded by the choroideremia-like gene. J Biol Chem 269: 2111-2117. PubMed: 8294464. (Pubitemid 24035421)
7. Cremers FP, van de Pol DJ, van Kerkhoff LP, Wieringa B, Ropers HH (1990) Cloning of a gene that is rearranged in patients with choroideraemia. Nature 347: 674-677. doi:10.1038/347674a0. PubMed: 2215697.
8. Larijani B, Hume AN, Tarafder AK, Seabra MC (2003) Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases. J Biol Chem 278: 46798-46804. doi:10.1074/jbc.M307799200. PubMed: 12941939. (Pubitemid 37452259)
9. Seabra MC, Ho YK, Anant JS (1995) Deficient geranylgeranylation of Ram/Rab27 in choroideremia. J Biol Chem 270: 24420-24427. doi: 10.1074/jbc.270.41.24420. PubMed: 7592656.
10. Storrie B (2005) Microinjection as a tool to explore small GTPase function. Methods Enzymol 404: 26-42. doi:10.1016/S0076-6879(05)04004-8. PubMed: 16413255.
11. Kalinin A, Thomä NH, Iakovenko A, Heinemann I, Rostkova E et al. (2001) Expression of mammalian geranylgeranyltransferase type-II in Escherichia coli and its application for in vitro prenylation of Rab proteins. Protein Expr Purif 22: 84-91. doi:10.1006/prep.2001.1423. PubMed: 11388804. (Pubitemid 32548223)
12. Nguyen UT, Guo Z, Delon C, Wu Y, Deraeve C et al. (2009) Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol 5: 227-235. doi:10.1038/nchembio.149. PubMed: 19219049.
13. Ostrowski SM, Wilkinson BL, Golde TE, Landreth G (2007) Statins reduce amyloid-beta production through inhibition of protein isoprenylation. J Biol Chem 282: 26832-26844. doi:10.1074/jbc.M702640200. PubMed: 17646164. (Pubitemid 47501902)
14. Crick DC, Andres DA, Waechter CJ (1997) Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation. Biochem Biophys Res Commun 237: 483-487. doi:10.1006/bbrc.1997.7145. PubMed: 9299388. (Pubitemid 27434709)
15. Ownby SE, Hohl RJ (2003) Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. Lipids 38: 751-759. doi:10.1007/s11745-003-1123-8. PubMed: 14506838. (Pubitemid 37362267)
16. Bantscheff M, Schirle M, Sweetman G, Rick J, Kuster B (2007) Quantitative mass spectrometry in proteomics: a critical review. Anal Bioanal Chem 389: 1017-1031. doi:10.1007/s00216-007-1486-6. PubMed: 17668192. (Pubitemid 47482251)
17. Old WM, Meyer-Arendt K, Aveline-Wolf L, Pierce KG, Mendoza A et al. (2005) Comparison of label-free methods for quantifying human proteins by shotgun proteomics. Mol Cell Proteomics 4: 1487-1502. doi: 10.1074/mcp.M500084- MCP200. PubMed: 15979981. (Pubitemid 41555475)
18. Zhu W, Smith JW, Huang CM (2010) Mass spectrometry-based label-free quantitative proteomics. Journal of biomedicine & biotechnology 2010: 840518
19. Alory C, Balch WE (2001) Organization of the Rab-GDI/CHM superfamily: the functional basis for choroideremia disease. Traffic 2: 532-543. doi:10.1034/j.1600-0854.2001.20803.x. PubMed: 11489211. (Pubitemid 32725398)
20. Wilson SM, Yip R, Swing DA, O'Sullivan TN, Zhang Y et al. (2000) A mutation in Rab27a causes the vesicle transport defects observed in ashen mice. Proc Natl Acad Sci U S A 97: 7933-7938. doi:10.1073/pnas.140212797. PubMed: 10859366. (Pubitemid 30460751)
21. Gordiyenko NV, Fariss RN, Zhi C, MacDonald IM (2010) Silencing of the CHM gene alters phagocytic and secretory pathways in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 51: 1143-1150. doi: 10.1167/iovs.09-4117. PubMed: 19741243.
22. Brooks BP, Larson DM, Chan CC, Kjellstrom S, Smith RS et al. (2007) Analysis of ocular hypopigmentation in Rab38cht/cht mice. Invest Ophthalmol Vis Sci 48: 3905-3913. doi:10.1167/iovs.06-1464. PubMed: 17724166. (Pubitemid 351261008)
23. Lopes VS, Wasmeier C, Seabra MC, Futter CE (2007) Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis. Mol Biol Cell 18: 3914-3927. doi:10.1091/mbc.E07-03-0268. PubMed: 17671165. (Pubitemid 47519484)
24. Osanai K, Higuchi J, Oikawa R, Kobayashi M, Tsuchihara K et al. (2010) Altered lung surfactant system in a Rab38-deficient rat model of Hermansky-Pudlak syndrome. Am J Physiol Lung Cell Mol Physiol 298: L243-L251. doi:10.1152/ajplung.00242.2009. PubMed: 19897744.
25. Hutagalung AH, Novick PJ (2011) Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev 91: 119-149. doi:10.1152/physrev.00059.2009. PubMed: 21248164.
26. Anand V, Barral DC, Zeng Y, Brunsmann F, Maguire AM et al. (2003) Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus. Vision Res 43: 919-926. doi:10.1016/S0042-6989(02)00389-9. PubMed: 12668061. (Pubitemid 36369132)
27. Maguire AM, Simonelli F, Pierce EA, Pugh EN Jr., Mingozzi F et al. (2008) Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med 358: 2240-2248. doi:10.1056/NEJMoa0802315. PubMed: 18441370. (Pubitemid 351724453)
28. Tolmachova T, Tolmachov OE, Wavre-Shapton ST, Tracey-White D, Futter CE et al. (2012) CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the RPE of choroideremia mice. Journal of Gene Medicine.
29. Strunnikova NV, Barb J, Sergeev YV, Thiagarajasubramanian A, Silvin C et al. (2009) Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patients. PLOS ONE 4: e8402. doi:10.1371/journal.pone.0008402. PubMed: 20027300.
30. Alexandrov K, Simon I, Yurchenko V, Iakovenko A, Rostkova E et al. (1999) Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase. Eur J Biochem 265: 160-170. doi: 10.1046/j.1432-1327.1999.00699.x. PubMed: 10491170. (Pubitemid 29466024)
31. Armstrong SA, Brown MS, Goldstein JL, Seabra MC (1995) Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins. Methods Enzymol 257: 30-41. doi:10.1016/S0076-6879(95)57007-1. PubMed: 8583933.
32. Martin P, Albagli O, Poggi MC, Boulukos KE, Pognonec P (2006) Development of a new bicistronic retroviral vector with strong IRES activity. BMC Biotechnol 6: 4. doi:10.1186/1472-6750-6-4. PubMed: 16409632.
33. Albagli-Curiel O, Lécluse Y, Pognonec P, Boulukos KE, Martin P (2007) A new generation of pPRIG-based retroviral vectors. BMC Biotechnol 7: 85. doi:10.1186/1472-6750-7-85. PubMed: 18053131.
34. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101. doi:10.1126/science.1106148. PubMed: 15718470. (Pubitemid 40262113)
35. van de Wetering M, Oving I, Muncan V, Pon Fong MT, Brantjes H et al. (2003) Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep 4: 609-615. doi: 10.1038/sj.embor.embor865. PubMed: 12776180. (Pubitemid 36939953)
36. Rak A, Niculae A, Kalinin A, Thomä NH, Sidorovitch V et al. (2002) In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex. Protein Expr Purif 25: 23-30. doi: 10.1006/prep.2001.1605. PubMed: 12071695. (Pubitemid 36034997)
37. Searle BC (2010) Scaffold: a bioinformatic tool for validating MS/MS-based proteomic studies. Proteomics 10: 1265-1269. doi:10.1002/pmic. 200900437. PubMed: 20077414.
38. Dong MQ, Venable JD, Au N, Xu T, Park SK et al. (2007) Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science 317: 660-663. doi:10.1126/science.1139952. PubMed: 17673661. (Pubitemid 47229964)