Decreased expression of stromal estrogen receptor α and β in prostate cancer

American Journal of Translational Research

Volumn 6, Issue 2, 2014, Pages 140-146

  Daniels, Garrett ^a   Lin Gellert, Lan ^a   Melamed, Jonathan ^a   Hatcher, David ^a   Li, Yirong ^a   Wei, Jianjun ^a   Wang, Jinhua ^a   Lee, Peng ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Estrogen receptors; Prostate cancer; Stromal

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; PEROXIDASE;

ADULT; ARTICLE; BREAST CANCER; CONTROLLED STUDY; GLEASON SCORE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PROSTATE CANCER; PROTEIN EXPRESSION; STROMA; TISSUE MICROARRAY;

EID: 84892981396     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007; 57: 43-66.
2. Freedland SJ, Isaacs WB, Platz EA, Terris MK, Aronson WJ, Amling CL, Presti JC Jr and Kane CJ. Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: a search database study. J Clin Oncol 2005; 23: 7546-7554.
3. Cunha GR, Hayward SW, Wang YZ and Ricke WA. Role of the stromal microenvironment in carcinogenesis of the prostate. Int J Cancer 2003; 107: 1-10.
4. Joesting MS, Cheever TR, Volzing KG, Yamaguchi TP, Wolf V, Naf D, Rubin JS and Marker PC. Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Dev Biol 2008; 317: 161-173.
5. Karagiannis GS, Poutahidis T, Erdman SE, Kirsch R, Riddell RH and Diamandis EP. Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue. Mol Cancer Res 2012; 10: 1403-1418.
6. Cunha GR. Mesenchymal-epithelial interactions: past, present, and future. Differentiation 2008; 76: 578-586.
7. Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD and Cunha GR. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 1999; 59: 5002-5011.
8. Dakhova O, Ozen M, Creighton CJ, Li R, Ayala G, Rowley D and Ittmann M. Global gene expression analysis of reactive stroma in prostate cancer. Clin Cancer Res 2009; 15: 3979-3989.
9. Orr B, Riddick AC, Stewart GD, Anderson RA, Franco OE, Hayward SW and Thomson AA. Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate. Oncogene 2012; 31: 1130-1142.
10. Linja MJ and Visakorpi T. Alterations of androgen receptor in prostate cancer. J Steroid Biochem Mol Biol 2004; 92: 255-264.
11. Taplin ME and Balk SP. Androgen receptor: a key molecule in the progression of prostate cancer to hormone independence. J Cell Biochem 2004; 91: 483-490.
12. Ho SM. Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidates. J Cell Biochem 2004; 91: 491-503.
13. Bonkhoff H, Fixemer T, Hunsicker I and Remberger K. Progesterone receptor expression in human prostate cancer: correlation with tumor progression. Prostate 2001; 48: 285-291.
14. Levin ER. Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol 2005; 19: 1951-1959.
15. Fixemer T, Remberger K and Bonkhoff H. Differential expression of the estrogen receptor beta (ERbeta) in human prostate tissue, premalignant changes, and in primary, metastatic, and recurrent prostatic adenocarcinoma. Prostate 2003; 54: 79-87.
16. Bonkhoff H, Fixemer T, Hunsicker I and Remberger K. Estrogen receptor gene expression and its relation to the estrogen-inducible HSP27 heat shock protein in hormone refractory prostate cancer. Prostate 2000; 45: 36-41.
17. Bonkhoff H, Fixemer T, Hunsicker I and Remberger K. Estrogen receptor expression in prostate cancer and premalignant prostatic lesions. Am J Pathol 1999; 155: 641-647.
18. Prins GS and Korach KS. The role of estrogens and estrogen receptors in normal prostate growth and disease. Steroids 2008; 73: 233-244.
19. Ricke WA, Wang Y and Cunha GR. Steroid hormones and carcinogenesis of the prostate: the role of estrogens. Differentiation 2007; 75: 871-882.
20. Cunha GR, Wang YZ, Hayward SW and Risbridger GP. Estrogenic effects on prostatic differentiation and carcinogenesis. Reprod Fertil Dev 2001; 13: 285-296.
21. Bonkhoff H and Berges R. The evolving role of oestrogens and their receptors in the development and progression of prostate cancer. Eur Urol 2009; 55: 533-542.
22. Setlur SR, Mertz KD, Hoshida Y, Demichelis F, Lupien M, Perner S, Sboner A, Pawitan Y, Andren O, Johnson LA, Tang J, Adami HO, Calza S, Chinnaiyan AM, Rhodes D, Tomlins S, Fall K, Mucci LA, Kantoff PW, Stampfer MJ, Andersson SO, Varenhorst E, Johansson JE, Brown M, Golub TR and Rubin MA. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst 2008; 100: 815-825.
23. Ellem SJ and Risbridger GP. The dual, opposing roles of estrogen in the prostate. Ann N Y Acad Sci 2009; 1155: 174-186.
24. McPherson SJ, Ellem SJ, Simpson ER, Patchev V, Fritzemeier KH and Risbridger GP. Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia. Endocrinology 2007; 148: 566-574.
25. Horvath LG, Henshall SM, Lee CS, Head DR, Quinn DI, Makela S, Delprado W, Golovsky D, Brenner PC, O'Neill G, Kooner R, Stricker PD, Grygiel JJ, Gustafsson JA and Sutherland RL. Frequent loss of estrogen receptor-beta expression in prostate cancer. Cancer Res 2001; 61: 5331-5335.
26. Li Y, Li CX, Ye H, Chen F, Melamed J, Peng Y, Liu J, Wang Z, Tsou HC, Wei J, Walden P, Garabedian MJ and Lee P. Decrease in stromal androgen receptor associates with androgen-independent disease and promotes prostate cancer cell proliferation and invasion. J Cell Mol Med 2008; 12: 2790-2798.
27. Yu Y, Liu L, Xie N, Xue H, Fazli L, Buttyan R, Wang Y, Gleave M and Dong X. Expression and function of the progesterone receptor in human prostate stroma provide novel insights to cell proliferation control. J Clin Endocrinol Metab 2013; 98: 2887-2896.
28. Tuxhorn JA, Ayala GE and Rowley DR. Reactive stroma in prostate cancer progression. J Urol 2001; 166: 2472-2483.
29. Wikstrom P, Marusic J, Stattin P and Bergh A. Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients. Prostate 2009; 69: 799-809.
30. Santti R, Newbold RR, Makela S, Pylkkanen L and McLachlan JA. Developmental estrogenization and prostatic neoplasia. Prostate 1994; 24: 67-78.
31. Singh PB, Matanhelia SS and Martin FL. A potential paradox in prostate adenocarcinoma progression: oestrogen as the initiating driver. Eur J Cancer 2008; 44: 928-936.
32. Prins GS, Birch L, Couse JF, Choi I, Katzenellenbogen B and Korach KS. Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with alphaERKO and betaERKO mice. Cancer Res 2001; 61: 6089-6097.
33. Haqq C, Li R, Khodabakhsh D, Frolov A, Ginzinger D, Thompson T, Wheeler T, Carroll P and Ayala G. Ethnic and racial differences in prostate stromal estrogen receptor alpha. Prostate 2005; 65: 101-109.
34. Hetzl AC, Montico F, Lorencini RM, Kido L, Candido E, Billis A, Ferreira U and Cagnon VH. Fibroblast growth factor, estrogen, and prolactin receptor features in different grades of prostatic adenocarcinoma in elderly men. Microsc Res Tech 2013; 76: 321-330.