Cytotoxic effects of zoledronic acid on human epithelial cells and gingival fibroblasts

Brazilian Dental Journal

Volumn 24, Issue 6, 2013, Pages 551-558

  Basso, Fernanda Gonçalves ^a   Pansani, Taisa Nogueira ^b   de Oliveira, Camila Fávero ^c   Turrioni, Ana Paula Silveira ^b   Soares, Diana Gabriela ^b   Hebling, Josimeri ^b   de Souza, Carlos AlbertoCosta ^b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bisphosphonates; Cytotoxicity; Epithelial cells; Fibroblasts

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; BONE DENSITY CONSERVATION AGENT; IMIDAZOLE DERIVATIVE; ZOLEDRONIC ACID;

BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS OF THE JAW; CELL COUNT; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FIBROBLAST; GINGIVA; HUMAN; IN VITRO STUDY; SCANNING ELECTRON MICROSCOPY;

BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS OF THE JAW; BONE DENSITY CONSERVATION AGENTS; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; DIPHOSPHONATES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FIBROBLASTS; GINGIVA; HUMANS; IMIDAZOLES; IN VITRO TECHNIQUES; MICROSCOPY, ELECTRON, SCANNING;

EID: 84892975024     PISSN: 01036440     EISSN: 18064760     Source Type: Journal    
DOI: 10.1590/0103-6440201302229     Document Type: Article

References (25)

1. Civitelli R, Napoli N, Armamento-Villareal R. Use of intravenous bisphosphonates in osteoporosis. Curr Osteoporos Rep 2007;5:8-13.
2. Cohen SB. An update on bisphosphonates. Curr Rheumatol Rep 2004;6:59-65.
3. Rogers MJ, Watts DJ, Russel RG. Overview of bisphosphonates. Cancer 1997;80:1652-1660.
4. Rogers MJ, Gordon S, Benford HL, Coxon FP, Luckman SP, Monkkonen J, et al. Cellular and molecular mechanisms of action of bisphosphonates. Cancer Supl 2000;88:2961-2978.
5. Lawson MA, Xia Z, Barnett BL, Triffitt JT, Phipps RJ, Dunford JE, et al. Differences between bisphosphonates in binding affinities for hydroxyapatite. J Biomed Mater Res Part B: Appl Biomater 2010;92:149-155.
6. Allen MR, Burr DB. The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data. J Oral Maxillofac Surg 2009;67:61-70.
7. Otto S, Pautke C, Opelz C, Wesphal I, Drosse, I, Swager J, et al. Osteonecrosis of the jaw: effects of bisphosphonate type, local concentration, and acidic milieu on the pathomechanism. J Oral Maxillofac Surg 2010;68:2837-2845.
8. Reid IR, Booland MJ. Is bisphosphonate-associated osteonecrosis of the jaw caused by soft tissue toxicity? Bone 2007;41:318-320.
9. Scheper MA, Badros A, Chausparat R, Cullen KJ, Meiller TF. Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol 2009;144:667-676.
10. Scheper MA, Badros A, Salama AR, Wartburton G, Cullen KJ, Weikel DS, et al. A novel bioassay model to determine clinically significant bisphosphonate levels. Support Care Cancer 2009;17:1553-1557.
11. Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg 2004;62:527-534.
12. Walter C, Klein MO, Pabst A, Al-Nawas B, Duscher H, Ziebart T. Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells. Clin Oral Investig 2010;14:35-41.
13. Kumar SKS, Gorur A, Schaauddin C, Shuler CF, Costerton JW, Sedghizadeh PP. The role of microbial biofilms in osteonecrosis of the jaw associated with bisphosphonate therapy. Curr Osteoporos Rep 2010;8:40-48.
14. Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 2005;43:5721-5732.
15. Basso FG, Pansani TN, Turrioni APS, Bagnato VS, Hebling J, de Souza Costa CA. In vitro wound healing improvement by low-level laser therapy application in cultured gingival fibroblasts. Int J Dent 2012 [Epub ahead of print. DOI: 10.1155/2012/719452].
16. Wiegand C, Hipler U. Methods for the measurement of cell and tissue compatibility including tissue regeneration process. GMS Krankenhhyg Interdiszip 2008;3:1863-5245.
17. Basso FG, Oliveira CF, Kurachi C, Hebling J, de Souza Costa CA. Biostimulatory effect of low-level laser therapy on keratinocytes in vitro. Lasers Med Sci 2013;28:367-374.
18. De Souza Costa CA, Duarte PT, de Souza PP, Giro EM, Hebling J. Cytotoxic effects and pulpal response caused by a mineral trioxide aggregate formulation and calcium hydroxide. Am J Dent 2008;21:255-261.
19. Oliveira CF, Basso FG, Lins ECC, Kurachi C, Hebling J, Bagnato VS, et al. Increased viability of odontoblast-like cells subjected to low-level laser irradiation. Laser Phys 2010;20:1659-1666.
20. Read SM, Northcote DH. Minimization of variation in the response to different proteins of the Coomassie blue G dye-binding assay for protein. Anal Biochem 1981;116:53-64.
21. Oliveira CF, Basso FG, Lins EC, Kurachi C, Hebling J, Bagnato VS, et. al. In vitro effect of low-level laser on odontoblast-like cells. Laser Phys Lett 2011;8:155-163.
22. Simon MJK, Niehoff P, Kimming B, Wiltfang J, Açil Y. Expression profile and synthesis of different collagen types I, II III and V of human gingival fibroblasts, osteoblasts, ans SaOs-2 cells after bisphosphonate treatment. Clin Oral Investig 2010;14:51-58.
23. Migliorati CA, Siegel MA, Elting LS. Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment. Lancet Oncol 2006;7:508-514.
24. Werner S, Krieg T, Smola H. Keratinocyte-fibroblast interactions in wound healing. J Investigative Dermatol 2007;127:998-1008.
25. Ravosa MJ, Ning J, Liu Y, Stack MS. Bisphosphonate effects on the behavior of oral epithelial cells and oral fibroblasts. Arch Oral Biol 2011;56:491-498.