Fibronectin promotes migration and invasion of ovarian cancer cells through up-regulation of FAK-PI3K/Akt pathway

Cell Biology International

Volumn 38, Issue 1, 2014, Pages 85-91

  Yousif, Nasser Ghaly ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Cancer; Cell adhesion; Cell migration; Matrix metalloproteinases

Indexed keywords

FIBRONECTIN; FOCAL ADHESION KINASE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL MIGRATION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FAK GENE; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; OVARY CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR INVASION; WESTERN BLOTTING;

CANCER; CELL ADHESION; CELL MIGRATION; MATRIX METALLOPROTEINASES;

CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; FIBRONECTINS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; OVARIAN NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84892974771     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10184     Document Type: Article

References (32)

1. Burridge K, Chrzanowska-Wodnicka M (1996) Focal adhesions, contractility, and signaling. Annu Rev Cell Dev Biol 12: 463-518.
2. Cance WG, Harris JE, Iacocca MV, Roche E, Yang X, Chang J, Simkins S, Xu L (2000a) Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res 6: 2417-23.
3. Cance WG, Harris JE, Iacocca MV, Roche E, Yang X, Chang J, Simkins S, Xu L (2000b) Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res 6(6): 2417-23.
4. Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL (1995) Interaction of focal adhesion kinase with cytoskeletal protein talin. J Biol Chem 270: 16995-9.
5. Chen HC, Appeddu PA, Isoda H, Guan JL (1996) Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J Biol Chem 271: 26329-34.
6. Fawcett J, Harris AL (1992) Cell adhesion molecule and cancer. Curr Opin Oncol 4: 142-8.
7. Ganguly K, Sen T, Pal S, Biswas J, Chatterjee A (2012) Studies on focal adhesion kinase in human breast cancer cell MDA-MB-231. Ad Bio Chem 22: 29-42.
8. Gassmann P, Enns A, Haier J (2004) Role of tumor cell adhesion and migration in organ-specific metastasis formation. Oncology 27(6): 577-82.
9. Heino J (1993) Integrin-type extracellular matrix receptors in cancer and inflammation. Ann Med 25: 335-42.
10. Hirtenlehne K, Pec M, Kubista E, Singer CF (2002) Extracellular matrix proteins influence phenotype and cytokine expression in human breast cancer cell lines. Eur Cytokine Netw 13: 234-40.
11. Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD (2003) Differential regulation of cell motility and invasion by FAK. J Cell Biol 160: 753-67.
12. Ito MSH, Zinner MJ, Ashley SW,Whang EE (2004) Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells. Surgery 135: 555-62.
13. Judson PL, He X, Cance WG, Van Le L (1999) Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer 86: 1551-6.
14. Mao Y, Schwarzbauer JE (2005) Fibronectin fibrillogenesis, a cellmediated matrix assembly process. Matrix Biol 24: 389-99.
15. McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG, FrameMC (2005) The role of focal-adhesion kinase in cancer- a new therapeutic opportunity. Nat Rev Cancer 5(7): 505-15.
16. Meng XN, Jin Y, Yu Y, Bai J, Liu GY, Zhu J, Zhao YZ,Wang Z, Chen F, Lee K.-Y (2009) Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion. Br J Cancer 101(2): 327-34.
17. Miranti CK, Brugge JS (2002) Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol 4: E83-90.
18. Perez RP, Godwin AK, Hamilton TC, Ozols RF (1991) Ovarian cancer biology. Semin Oncol 18: 186-204.
19. Reiske HR, Kao SC, Cary LA, Guan JL, Lai JF, Chen HC (1999) Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration. J Biol Chem 274: 12361-66.
20. Rintoul RC, Sethi T (2002a) Extracellular matrix regulation of drug resistance in small-cell lung cancer. Clin Sci 102: 417-24.
21. Rintoul RC, Sethi T (2002b) Extracellular matrix regulation of drug resistance in small-cell lung carcinoma. Clin Sci (Lond) 102: 417-24.
22. Ritzenthaler JD, Han S, Roman J (2008) Stimulation of lung carcinoma cell growth by fibronectin-integrin signalling. Mol Biosyst 4: 1160-9.
23. Rudolph R, ChereshD (1990) Cell adhesion mechanisms and their potential impact on wound healing and tumor control. Clin Plast Surg 17: 457-62.
24. Sawai H, Okada Y, Funahashi H, Matsuo Y, Takahashi H, Takeyama H, Manabe T (2005) Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation. Mol Cancer 4: 37.
25. Schaller MD, Borgman CA, Cobb BS, Vines RR, Reynolds AB, Parsons JT (1992) pp125 FAK a structurally distinctive proteintyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA 89(11): 5192-6.
26. Schaller MD, Borgman CA, Parsons JT (1993) Autonomous expression of a non-catalytic domain of the focal adhesionassociated protein tyrosine kinase pp125FAK. Mol Cell Biol 13: 785-79.
27. Thant AA, Nawa A, Kikkawa F, Ichigotani Y, Zhang Y, Sein TT, Amin AR, Hamaguchi M (2000) Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells. Clin Exp Metastasis 18: 423-28.
28. Turner CE, Miller JT (1994) Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region. J Cell Sci 107: 1583-91.
29. Williams CM, Engler AJ, Slone RD, Galante LL, Schwarzbauer JE (2008) Fibronectin expression modulates mammary epithelial cell proliferation during acinar differentiation. Cancer Res 68: 3185-92.
30. Xia H, Nho RS, Judy K, Jill K, Henke CA (2004) FAK is upstream of PI-3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a b1 integrin-viability signaling pathway. J Biol Chem 279: 33024-34.
31. Zeng ZZ, Jia Y, Hahn NJ, Markwart SM, Rockwood KF, Livant DL (2006) Role of focal adhesion kinase and phosphatidylinositol 30-kinase in integrin fibronectin receptor-mediated, matrix metalloproteinase-1-dependent invasion by metastatic prostate cancer cells. Cancer Res 66: 8091-9.
32. Zijlstra A, Lewis J, Degryse B, Stuhlmann H, Quigley JP (2008) The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin cd151. Cancer Cell 13: 221-34.