Flow cytometric identification of 76 patients with biclonal disease among 5523 patients with chronic lymphocytic leukaemia (B-CLL) and its genetic characterization

British Journal of Haematology

Volumn 164, Issue 4, 2014, Pages 565-569

  Kern, Wolfgang ^a   Bacher, Ulrike ^a   Schnittger, Susanne ^a   Dicker, Frank ^a   Alpermann, Tamara ^a   Haferlach, Torsten ^a   Haferlach, Claudia ^a  

^a MLL MUNICH LEUKEMIA LABORATORY   (Germany)

Author keywords

Biclonal chronic lymphocytic leukaemia; Chromosome banding analysis; IGHV mutation analysis; Interphase fluorescence in situ hybridization; Multiparameter flow cytometry

Indexed keywords

B LYMPHOCYTE RECEPTOR;

ADULT; AGED; ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME BANDING PATTERN; CHRONIC LYMPHATIC LEUKEMIA; CLONAL EVOLUTION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; HUMAN; IGHV GENE; IMMUNOGLOBULIN HEAVY CHAIN GENE; MAJOR CLINICAL STUDY; MALE; MULTIPARAMETER FLOW CYTOMETRY; MUTATIONAL ANALYSIS; PATIENT IDENTIFICATION; PRIORITY JOURNAL; VERY ELDERLY;

BICLONAL CHRONIC LYMPHOCYTIC LEUKAEMIA; CHROMOSOME BANDING ANALYSIS; IGHV MUTATION ANALYSIS; INTERPHASE FLUORESCENCE IN SITU HYBRIDIZATION; MULTIPARAMETER FLOW CYTOMETRY;

ADULT; AGED; AGED, 80 AND OVER; CHROMOSOME BANDING; COHORT STUDIES; FEMALE; FLOW CYTOMETRY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84892973751     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12652     Document Type: Article

References (13)

1. Binet, J.L., Caligaris-Cappio, F., Catovsky, D., Cheson, B., Davis, T., Dighiero, G., Dohner, H., Hallek, M., Hillmen, P., Keating, M., Montserrat, E., Kipps, T.J. & Rai, K. (2006) Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia. Blood, 107, 859-861.
2. Crespo, M., Bosch, F., Villamor, N., Bellosillo, B., Colomer, D., Rozman, M., Marce, S., Lopez-Guillermo, A., Campo, E. & Montserrat, E. (2003) ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. The New England Journal of Medicine, 348, 1764-1775.
3. Dicker, F., Schnittger, S., Haferlach, T., Kern, W. & Schoch, C. (2006) Immunostimulatory oligonucleotide-induced metaphase cytogenetics detect chromosomal aberrations in 80% of CLL patients: a study of 132 CLL cases with correlation to FISH, IgVH status, and CD38 expression. Blood, 108, 3152-3160.
4. Dohner, H., Stilgenbauer, S., Benner, A., Leupolt, E., Krober, A., Bullinger, L., Dohner, K., Bentz, M. & Lichter, P. (2000) Genomic aberrations and survival in chronic lymphocytic leukemia. The New England Journal of Medicine, 343, 1910-1916.
5. Gonzalez-Campos, J., Rios-Herranz, E., De Blas-Orlando, J.M., Martin-Noya, A., Parody-Ruiz-Berdejo, R. & Rodriguez-Fernandez, J.M. (1997) Chronic lymphocytic leukemia with two cellular populations: a biphenotypic or biclonal disease. Annals of Hematology, 74, 243-246.
6. Haferlach, C. & Bacher, U. (2011) Cytogenetic methods in chronic lymphocytic leukemia. Methods in Molecular Biology, 730, 119-130.
7. Hallek, M. (2009) State-of-the-art treatment of chronic lymphocytic leukemia. Hematology/the Education Program of the American Society of Hematology, 2009, 440-449.
8. Hsi, E.D., Hoeltge, G. & Tubbs, R.R. (2000) Biclonal chronic lymphocytic leukemia. American Journal of Clinical Pathology, 113, 798-804.
9. Kern, W., Dicker, F., Schnittger, S., Haferlach, C. & Haferlach, T. (2009) Correlation of flow cytometrically determined expression of ZAP-70 using the SBZAP antibody with IgVH mutation status and cytogenetics in 1, 229 patients with chronic lymphocytic leukemia. Cytometry. Part B, Clinical Cytometry, 76, 385-393.
10. Müller-Hermelink, H., Montserrat, E., Catovsky, D., Campo, E., Harris, N. & Stein, H. (2008) Chronic lymphocytic leukemia/small lymphocytic lymphoma. In: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (ed. by S. Swerdlow), pp. 180-182. IARC Press: Lyon.
11. Orchard, J.A., Ibbotson, R.E., Davis, Z., Wiestner, A., Rosenwald, A., Thomas, P.W., Hamblin, T.J., Staudt, L.M. & Oscier, D.G. (2004) ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. Lancet, 363, 105-111.
12. Sanchez, M.L., Almeida, J., Gonzalez, D., Gonzalez, M., Garcia-Marcos, M.A., Balanzategui, A., Lopez-Berges, M.C., Nomdedeu, J., Vallespi, T., Barbon, M., Martin, A., de la Fuente, P., Martin-Nunez, G., Fernandez-Calvo, J., Hernandez, J.M., San Miguel, J.F. & Orfao, A. (2003) Incidence and clinicobiologic characteristics of leukemic B-cell chronic lymphoproliferative disorders with more than one B-cell clone. Blood, 102, 2994-3002.
13. Stilgenbauer, S., Bullinger, L., Lichter, P. & Dohner, H. (2002) Genetics of chronic lymphocytic leukemia: genomic aberrations and V(H) gene mutation status in pathogenesis and clinical course. Leukemia, 16, 993-1007.