Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 3, 2014, Pages 725-732

  Kim, Jee Hye ^a   Ko, Jung A ^a   Kim, Jun Tae ^b   Cha, Dong Su ^a   Cho, Jin Hun ^c   Park, Hyun Jin ^a   Shin, Gye Hwa ^a  

^a Korea University   (South Korea)

^b Keimyung University   (South Korea)

^c Coway Cosmetics RandD Center ^*  (South Korea)

Author keywords

capsaicin; confocal microscopy; HLB value; nanoemulsion; skin penetration

Indexed keywords

CAPSAICIN; CONFOCAL LASER SCANNING MICROSCOPY; ENHANCED SKIN PERMEATIONS; HLB VALUES; HYDROPHILE-LIPOPHILE BALANCE; NANOEMULSION; SKIN PENETRATION; TERNARY PHASE DIAGRAMS;

COREMAKING; MIXTURES; NONIONIC SURFACTANTS; OPTIMIZATION; RESINS; CONFOCAL MICROSCOPY; OIL SHALE; SURFACE ACTIVE AGENTS;

CONFOCAL MICROSCOPY; NONIONIC SURFACTANTS;

CAPSICUM;

CAPSAICIN; EMULSION; OLEORESINS; PLANT EXTRACT;

ADMINISTRATION AND DOSAGE; ANIMAL; CHEMISTRY; DRUG EFFECTS; EMULSION; EVALUATION STUDY; INTRADERMAL DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; PERMEABILITY; PROCEDURES; SKIN; SKIN ABSORPTION; SWINE;

ADMINISTRATION, CUTANEOUS; ANIMALS; CAPSAICIN; CHEMISTRY, PHARMACEUTICAL; EMULSIONS; PERMEABILITY; PLANT EXTRACTS; SKIN; SKIN ABSORPTION; SWINE;

EID: 84892963630     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf404220n     Document Type: Article

References (32)

1. Hayman, M.; Kam, P. C. A. Capsaicin: A review of its pharmacology and clinical applications Curr. Anaesth. Crit. Care 2008, 19, 338-343
2. Molina-Torres, J.; Garcia-Chavez, A.; Ramirez-Chavez, E. Antimicrobial properties of alkamides present in flavoring plants traditionally used in Mesoamerica: Affinin and capsaicin J. Ethnopharmacol. 1999, 64, 241-248
3. Ghosh, A. K.; Basu, S. Fas-associated factor 1 is a negative regulator in capsaicin induced cancer cell apoptosis Cancer Lett. 2010, 287, 142-149
4. Manzini, S.; Perretti, F.; Benedetti, L. D.; Pradelles, P.; Maggi, C. A.; Geppetti, P. A comparison of bradykinin- and capsaicin-induced myocardial and coronary effects in isolated perfused heart of the guinea pig: involvement of substance P and calcitonin gene-related peptide release J. Pharmacol. 1989, 97, 303-312
5. Xu, X.; Wang, P.; Zhao, Z.; Cao, T.; He, H.; Luo, Z.; Zhong, J.; Gao, F.; Zhu, Z.; Li, L.; Yan, Z.; Chen, J.; Ni, Y.; Liu, D.; Zhu, Z. Activation of transient receptor potential Vanilloid 1 by dietary capsaicin delays the onset of stroke in stroke-prone spontaneously hypertensive rats Stroke 2011, 42, 3245-3251
6. Hautkappe, M.; Roizen, M. F.; Toledano, A. Review of the effectiveness of capsaicin for painful cutaneous disorders and neural dysfunction Clin. J. Pain 1998, 14, 97-106
7. Bevan, S.; Szolcsányi, J. Sensory neuron-specific actions of capsaicin: mechanisms and applications Trends Pharmacol. Sci. 1990, 11, 330-333
8. Mousseau, D. D.; Sun, X.; Larson, A. A. An antinociceptive effect of capsaicin in the adult mouse mediated by the NH2-terminus of substance P1 J. Pharmacol. Exp. Ther. 1994, 268, 785-990
9. Kim, C. S.; Kawada, T.; Kim, B. S.; Han, I. S.; Choe, S. Y.; Kurata, T.; Yu, R. Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages Cell. Signalling 2003, 15, 299-306
10. Shakeel, F.; Shafiq, S.; Haq, N.; Alanazi, F. K.; Alsarra, I. A. Nanoemulsions as potential vehicles for transdermal and dermal delivery of hydrophobic compounds: an overview Expert Opin. Drug Delivery 2012, 9, 953-974
11. Prow, T. W.; Grice, J. E.; Lin, L. L.; Faye, R.; Butler, M.; Becker, W.; Wurm, E. M.; Yoong, C.; Robertson, T. A.; Soyer, H. P.; Roberts, M. S. Nanoparticles and microparticles for skin drug delivery Adv. Drug Delivery Rev. 2011, 63, 470-491
12. Kim, S.; Kim, J. C.; Sul, D.; Hwang, S. W.; Lee, S. H.; Kim, Y. H.; Tae, G.; Kim, J. Nanoparticle formulation for controlled release of capsaicin Nanosci. Nanotechnol. 2011, 11, 4586-4591
13. Schlupp, P.; Blaschke, T.; Kramer, K. D.; Holtje, H. -D.; Mehnert, W.; Schafer-Korting, M. Drug release and skin penetration from solid lipid nanoparticles and a base cream: A systematic approach from a comparison of three glucocorticoids Skin Pharmacol. Physiol. 2011, 24, 199-209
14. Li, B.; Ge, Z. Q. Nanostructured lipid carriers improve skin permeation and chemical stability of Idebenone AAPS PharmSciTech 2012, 13, 276-283
15. El Maghraby, G. M.; Barry, B. W.; Williams, A. C. Liposomes and skin: From drug delivery to model membranes Eur. J. Pharm. Sci. 2008, 34, 203-222
16. Yaw, B. H.; Yong, H. L.; Tzy, M. L.; Ren, J. W.; Yi, H. T.; Pao, C. W. Transdermal delivery of capsaicin derivative-sodium nonivamide acetate using microemulsions as vehicles Int. J. Pharm. 2008, 349, 206-211
17. Kong, M.; Park, H. J.; Feng, C.; Lin, H.; Cheng, X.; Chen, X. Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy Carbohydr. Polym. 2013, 94, 634-641
18. Choi, A. Y.; Kim, C. T.; Park, H. Y.; Kim, H. O.; Lee, N. R.; Lee, K. E.; Gwak, H. S. Pharmacokinetic characteristics of capsaicin-loaded nanoemulsions fabricated with alginate and chitosan J. Agric. Food Chem. 2013, 61, 2096-2102
19. Bouchemal, K.; Briançon, S.; Perrier, E.; Fessi, H. Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimization Int. J. Pharm. 2004, 280, 241-251
20. Kong, M.; Chen, X.; Park, H. J. Design and investigation of nanoemulsified carrier based on amphiphile-modified hyaluronic acid Carbohydr. Polym. 2011, 83, 462-469
21. Saria, A.; Lembeck, F.; Skofitsch, G. Determination of capsaicin in tissues and separation of capsaicin analogues by high-performance liquid chromatography J. Chromatogr. 1981, 208, 41-46
22. Kong, M.; Chen, X.; Kwon, D. K.; Park, H. J. Investigations on skin permeation of hyaluronic acid based nanoemulsion as transdermal carrier Carbohydr. Polym. 2011, 86, 837-843
23. Shakeel, F.; Ramadan, W. Transdermal delivery of anticancer drug caffeine from water-in-oil nanoemulsions Colloids Surf., B 2009, 75, 356-362
24. Choi, A. J.; Kim, C. J.; Cho, Y. J.; Hwang, J. K.; Kim, C. T. Effects of surfactants on the formation and stability of capsaicin loaded nanoemulsions Food Sci. Biotechnol. 2009, 18, 1161-1172
25. Bolzinger, M.; Briançon, S.; Pelletier, J.; Chevalier, Y. Penetration of drugs through skin, a complex rate-controlling membrane Curr. Opin. Colloid Interface Sci. 2012, 17, 156-165
26. Ng, S. F.; Rouse, J. J.; Sanderson, F. D.; Meidan, V.; Eccleston, G. M. Validation of a static franz diffusion cell system for in vitro permeation studies AAPS PharmSciTech 2010, 11, 1432-1441
27. Aripin, N. F. K.; Hashim, R.; Heidelberg, T.; Kweon, D. K.; Park, H. J. Effect of vesicle's membrane packing behaviour on skin penetration of model lipophilic drug J. Microencapsulation 2013, 30, 265-273
28. Chen, H.; Chang, X.; Weng, T.; Zhao, X.; Gao, Z.; Yang, Y.; Xu, H.; Yang, X. A study of microemulsion systems for transdermal delivery of triptolide J. Controlled Release 2004, 98, 427-436
29. Meidan, V. M. Methods for quantifying intrafollicular drug delivery: a critical appraisal Expert Opin. Drug Delivery 2010, 7, 1095-1108
30. Breternitz, M.; Flach, M.; Präßler, J.; Elsner, P.; Fluhr, J. W. Acute barrier disruption by adhesive tapes is influenced by pressure, time and anatomical location: integrity and cohesion assessed by sequential tape stripping; a randomized, controlled study Br. J. Dermatol. 2007, 156, 231-240
31. Nehal, K. S.; Dan, G.; Rajadhyasha, M. Skin imaging with reflectance confocal microscopy Semin. Cutaneous Med. Surg. 2008, 27, 37-43
32. Akihito, M.; Yusaku, I.; Kenji, K.; Tohko, I.; Tomohiro, H.; Kyoko, O.; Asami, S.; Masataka, N.; Shiho, S.; Hidehiko, Y.; Susumu, Y.; Makoto, T.; Tatsuo, W. Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1 Life Sci. 2006, 79, 2303-2310