An Evaluation of Human Demineralized Bone Matrices in a Rat Femoral Defect Model

Clinical Orthopaedics and Related Research

Volumn 413, Issue , 2003, Pages 281-290

  Oakes, Daniel A ^a   Lee, Christopher C ^b   Lieberman, Jay R ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

^c UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCEROL; HYALURONIC ACID;

ANIMAL MODEL; ARTICLE; BONE DEFECT; BONE DEMINERALIZATION; BONE GRAFT; BONE MATRIX; BONE RADIOGRAPHY; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; FEMUR; HISTOLOGY; HUMAN; HUMAN TISSUE; IMPLANT; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME; AGED; ANIMAL; BONE DISEASE; BONE PROSTHESIS; DISEASE MODEL; EVALUATION; FEMALE; MALE;

AGED; ANIMALS; BONE DISEASES; BONE MATRIX; BONE SUBSTITUTES; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; RATS;

EID: 0042476716     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/01.blo.0000073347.50837.16     Document Type: Article

References (25)

1. An HS, Simpson JM, Glover JM, Stephany J: Comparison between allograft plus demineralized bone matrix versus autograph in anterior cervical fusion. Spine 20:2211-2216, 1995.
2. Brostrom MPG, Saleh KJ, Einhorn TA: Osteoinductive growth factors in pre-clinical fracture and long bone defects models. Orthop Clin North Am 30:647-658, 1999.
3. Cobos JA, Lindsey RW, Gugala Z: The cylindrical titanium mesh cage for treatment of a long bone segmental defect: Description of a new technique and report of two cases. J Orthop Trauma 14:54-59, 2000.
4. Edwards JT, Diegmann MH, Scarborough NL: Osteoinduction of human demineralized bone: Characterization in a rat model. Clin Orthop 357:219-228, 1998.
5. Einhorn TA, Lane JM, Burstein AH, Kopman CR, Vigorita VJ: The healing of segmental bone defects induced by demineralized bone matrix: A radiographic and biomechanical study. J Bone Joint Surg 66A:274-279, 1984.
6. Feighan JE, Davy D, Prewett AB, Stevenson S: Induction of bone by a demineralized bone matrix gel: A study in a rat femoral defect model. J Orthop Res 13:881-891, 1995.
7. Goulet JA, Senunas LE, DeSilva GL, Greenfield ML: Autogenous iliac crest bone graft: Complications and functional assessment. Clin Orthop 339:76-81, 1997.
8. Lane JM, Bostrom, MPG: Bone Grafting and New Composite Biosynthetic Graft Materials. In Cannon Jr WD (ed). AAOS Instructional Course Lectures. Vol 47. Ed 57. Rosemont, IL, American Academy of Orthopaedic Surgeons Publications 525-534, 1998.
9. Lieberman JR, Daluiski A, Stevenson S, et al: The effect of regional gene therapy with bone morphogenetic protein-2 producing bone-marrow cells of repair of segmental femoral defects in rats. J Bone Joint Surg 81A:905-917, 1999.
10. Lieberman JR, Le LQ, Wu L, et al: Regional gene therapy with murine stromal cell line induced heterotopic and orthotopic bone formation in rodents. J Orthop Res 16:330-339, 1998.
11. Ludwig SC, Boden SD: Osteoinductive bone graft substitutes for spinal fusion. Orthop Clin North Am 30:635-645, 1999.
12. Martin GJ, Boden SD, Titus L, Scarborough NL: New formulations of demineralized bone matrix as a more effective graft alternative in experimental posterolateral lumbar spine arthrodesis. Spine 24:637-645, 1999.
13. Morone MA, Boden SD: Experimental posterolateral lumbar spine fusion with a demineralized bone matrix gel. Spine 23:159-167, 1998.
14. Oakes DA, Lieberman JR: Osteoinductive applications of regional gene therapy: Ex vivo gene transfer. Clin Orthop 379(Suppl):S101-S112, 2000.
15. Pals SD, Wilkins RM: Giant cell tumor of bone treated by curettage, cementation, and bone grafting. Orthopedics 6:703-708, 1992.
16. Russell JL, Block JE: Clinical utility of demineralized bone matrix for osseous defects, arthrodesis, and reconstruction: Impact of processing techniques and study methodology. Orthopedics 22:524-531, 1999.
17. Sassard WR, Eidman DK, Gray PM, et al: Augmenting local bone with Grafton demineralized bone matrix for posterolateral lumbar spine fusion: Avoiding second site autologous bone harvest. Orthopedics 23:1059-1065, 2000.
18. Solchaga LA, Dennis JE, Goldberg VM, Caplan AI: Hyaluronic acid-based polymers as cell carriers for tissue-engineered repair of bone and cartilage. J Orthop Res 17:205-213, 1999.
19. Stevenson S: Enhancement of fracture healing with autogenous and allogeneic bone grafts. Clin Orthop 355(Suppl):S239-S246, 1998.
20. Stevenson S: Biology of bone grafts. Orthop Clin North Am 30:543-552, 1999.
21. Summers BN, Eisenstein SM: Donor site pain from the ilium: A complication of lumbar spine fusion. J Bone Joint Surg 71B:677-680, 1989.
22. Tiedeman JJ, Garvin KL, Kile TA, Connolly JF: The role of a composite, demineralized bone matrix and bone marrow in the treatment of osseous defects. Orthopedics 18:1153-1158, 1995.
23. Toole BP: Hyaluronan in morphogenesis. J Intern Med 242:35-40, 1997.
24. Vail TP, Urbaniak JR: Donor site morbidity with use of vascularized autogenous fibular grafts. J Bone Joint Surg 78A:204-211, 1996.
25. Yasko AW, Lane JM, Fellinger EJ, et al: The healing of segmental bone defects induced by recombinant human bone morphogenetic protein (rhBMP-2). J Bone Joint Surg 74A:659-671, 1992.