Deletion of the Prorenin Receptor from the Ureteric Bud Causes Renal Hypodysplasia

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Song, Renfang ^a   Preston, Graeme ^a   Ichihara, Atsuhiro ^b   Yosypiv, Ihor V ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Institute of Endocrinology and Hypertention   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CYTOKERATIN AE1; FOXI1 PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PRORENIN RECEPTOR; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE ALPHA4; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRANCHING MORPHOGENESIS; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ETV4 GENE; ETV5 GENE; GENE; GENE DELETION; GENE EXPRESSION; GENE MUTATION; KIDNEY COLLECTING TUBULE; KIDNEY CONCENTRATING CAPACITY; KIDNEY CYST; KIDNEY HYPODYSPLASIA; KIDNEY HYPOPLASIA; KIDNEY MALFORMATION; MOUSE; MUTANT; NONHUMAN; POLYURIA; RET GENE; URETER; URINE ACIDIFICATION; URINE OSMOLALITY; URINE PH; WNT11 GENE;

ACIDS; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; DOWN-REGULATION; EPITHELIUM; GENE DELETION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HYDROGEN-ION CONCENTRATION; KIDNEY; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; KIDNEY TUBULES, COLLECTING; MICE; OSMOLAR CONCENTRATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-RET; PROTON-TRANSLOCATING ATPASES; RECEPTORS, CELL SURFACE; RNA, MESSENGER; URETER; WNT PROTEINS;

EID: 84877976034     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063835     Document Type: Article

References (41)

1. North American Pediatric Trials and Collaborative Studies. NAPRTCS Annual report. (2010) https://web.emmes.com/study/ped/annlrept/2010_Report.pdf.Accessed 2013 Jan 6.
2. Schedl A, (2007) Renal abnormalities and their developmental origin. Nat Rev Genet 8: 791-802.
3. Song R, Yosypiv IV, (2011) Genetics of Congenital Anomalies of the Kidney and Urinary Tract. Pediatric Nephrology 26: 353-364.
4. Costantini F, Kopan R, (2010) Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Dev Cell 18: 698-712.
5. Al-Awqati Q, Gao XB, (2011) Differentiation of intercalated cells in the kidney. Physiology (Bethesda) 26: 266-272.
6. Rojek A, Füchtbauer EM, Kwon TH, Frøkiaer J, Nielsen S, (2006) Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice. Proc Natl Acad Sci U S A 103: 6037-6042.
7. Jeong HW, Jeon US, Koo BK, Kim WY, Im SK, et al. (2009) Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest 119: 3290-3300.
8. Blomqvist SR, Vidarsson H, Fitzgerald S, Johansson BR, Ollerstam A, et al. (2004) Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. J Clin Invest 113: 1560-1570.
9. Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, et al. (2002) Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 109: 1417-1427.
10. Kinouchi K, Ichihara A, Sano M, Sano M, Sun-Wada GH, et al. (2010) The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes. Circ Res 107: 30-34.
11. Cruciat CM, Ohkawara B, Acebron SP, Karaulanov E, Reinhard C, et al. (2010) Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 327: 459-463.
12. Advani A, Kelly DJ, Cox AJ, White KE, Advani SL, et al. (2009) The (Pro)Renin Receptor Site-Specific and Functional Linkage to the Vacuolar H+-ATPase in the Kidney. Hypertension 54: 261-269.
13. Gonzalez AA, Lara LS, Luffman C, Seth DM, Prieto MC, (2011) Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats. Hypertension 57: 859-864.
14. Inoue H, Noumi T, Nagata M, Murakami H, Kanazawa H, (1999) Targeted disruption of the gene encoding the proteolipid subunit of mouse vacuolar H+-ATPase leads to early embryonic lethality. Biochim. Biophys 1413: 130-138.
15. Miura GI, Froelick GJ, Marsh DJ, Stark KL, Palmiter RD, (2003) The d subunit of the vacuolar ATPase (Atp6d) is essential for embryonic development. Transgenic Res 12: 131-133.
16. Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, et al. (2005) The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Proc Natl Acad Sci U S A 102: 13616-13621.
17. Fisher CE, Michael L, Barnett MW, Davies JA, (2001) Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney. Development 128: 4329-4338.
18. Zhao H, Kegg H, Grady S, Truong HT, Robinson ML, et al. (2004) Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud. Dev Biol 276: 403-415.
19. Barasch J, Pressler L, Connor J, Malik A, (1996) A ureteric bud cell line induces nephrogenesis in two steps by distinct signals. Am J Physiol 271: F50-F61.
20. Song R, Preston G, Yosypiv IV, (2011) Angiotensin II stimulates in vitro branching morphogenesis of the isolated ureteric bud. Mechanisms of Development 128: 359-367.
21. Song R, Spera M, Garrett C, El-Dahr S, Yosypiv IV, (2010) Angiotensin II AT2 Receptor Regulates Ureteric Bud Morphogenesis. American Journal of Physiology Renal Physiology 298: F807-F817.
22. Jouret F, Auzanneau C, Debaix H, Wada GH, Pretto C, et al. (2005) Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis. J Am Soc Nephrol 16: 3235-3246.
23. Nagalakshmi VK, Ren Q, Pugh MM, Valerius MT, McMahon AP, et al. (2011) Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int 79: 317-330.
24. Yosypiv IV, Schroeder M, El-Dahr SS, (2006) AT1R-EGFR crosstalk regulates ureteric bud branching morphogenesis. J Am Soc Nephrol 17: 1005-1014.
25. Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, et al. (2006) Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int 69: 105-113.
26. Buechling T, Bartscherer K, Ohkawara B, Chaudhary V, Spirohn K, et al. (2010) Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Curr Biol 20: 1263-1268.
27. Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, et al. (2009) Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet 41: 793-799.
28. Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, et al. (2009) A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 136: 161-171.
29. Basson MA, Watson-Johnson J, Shakya R, Akbulut S, Hyink D, et al. (2006) Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1. Dev Biol 299: 466-477.
30. Chi X, Michos O, Shakya R, Riccio P, Enomoto H, et al. (2009) Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. Dev Cell 17: 199-209.
31. Lu BC, Cebrian C, Chi X, Kuure S, Kuo R, et al. (2009) Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nat Genet 41: 1295-1302.
32. Jain S, Knoten A, Hoshi M, Wang H, Vohra B, et al. (2010) Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. J Clin Invest 120: 778-790.
33. Jain S, Encinas M, Johnson EM Jr, Midbrandt J, (2006) Critical and distinct roles for key RET tyrosine docking sites in renal development. Genes Dev 20: 321-333.
34. Cain JE, Di Giovanni V, Smeeton J, Rosenblum ND, (2010) Genetics of renal hypoplasia. Insights into the mechanisms controlling nephron endowment. Pediatr Res 68: 91-98.
35. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, et al. (2004) Renal vacuolar H+-ATPase. Physiol Rev 84: 1263-314.
36. Vidarsson H, Westergren R, Heglind M, Blomqvist SR, Breton S, et al. (2009) The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis. PLoS One 4: e4471.
37. Stover EH, Borthwick KJ, Bavalia C, Eady N, Fritz DM, et al. (2002) Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss. J Med Genet 39: 796-803.
38. Karet FE, (2002) Inherited distal renal tubular acidosis. J Am Soc Nephrol 13: 2178-2184.
39. Lin SH, Bichet DG, Sasaki S, Kuwahara M, Arthus MF, et al. (2002) Two novel aquaporin-2 mutations responsible for congenital nephrogenic diabetes insipidus in Chinese families. J Clin Endocrinol Metab 87: 2694-2700.
40. Oshima Y, Kinouchi K, Ichihara A, Sakoda M, Kurauchi-Mito A, et al. (2011) Prorenin receptor is essential for normal podocyte structure and function. J Am Soc Nephrol 22: 2203-2212.
41. Riediger F, Quack I, Qadri F, Hartleben B, Park JK, et al. (2011) Prorenin receptor is essential for podocyte autophagy and survival. J Am Soc Nephrol 22: 2193-2202.