Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 3, 2014, Pages

  Lee, Jiyoung ^a   Lee, Jinho ^b   Farquhar, Kevin S ^b   Yun, Jieun ^a,c   Frankenberger, Casey A ^a   Bevilacqua, Elena ^a   Yeung, Kam ^d   Kim, Eun Jin ^e   Balázsi, Gábor ^b   Rosner, Marsha Rich ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d UNIVERSITY OF TOLEDO   (United States)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Dynamics; EZH2; HDAC; Mathematical model

Indexed keywords

HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITOR; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BACH1; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL HETEROGENEITY; CONTROLLED STUDY; GENE EXPRESSION; GENE REPRESSION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MATHEMATICAL MODEL; METASTASIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; SINGLE CELL ANALYSIS; TRANSCRIPTION INITIATION SITE; TRIPLE NEGATIVE BREAST CANCER; AUTOREGULATION; CANCER GROWTH; FEEDBACK SYSTEM; HUMAN CELL; METASTATIC BREAST CANCER; PROTEIN DEPLETION; PROTEIN EXPRESSION;

DYNAMICS; EZH2; HDAC; MATHEMATICAL MODEL;

AMINO ACID MOTIFS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN IMMUNOPRECIPITATION; DISEASE PROGRESSION; FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS; FEEDBACK, PHYSIOLOGICAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VARIATION; HUMANS; MCF-7 CELLS; MODELS, THEORETICAL; NEOPLASM METASTASIS; OXIDATIVE STRESS; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PROMOTER REGIONS, GENETIC; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 84892939104     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1304840111     Document Type: Article

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