Use of a computerized C-reactive protein (CRP) based sepsis evaluation in very low birth weight (VLBW) infants: A five-year experience

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Coggins, Sarah A ^a   Wynn, James L ^b   Hill, Melissa L ^b   Slaughter, James C ^c   Ozdas Weitkamp, Asli ^d   Jalloh, Osman ^d   Russell Waitman, L ^d   Carnevale, Randy J ^d   Weitkamp, Jörn Hendrik ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MONROE CARELL JR CHILDREN S HOSPITAL AT VANDERBILT   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; C REACTIVE PROTEIN;

ABDOMINAL DISTENSION; ALGORITHM; AMNION FLUID; ANTIBIOTIC THERAPY; ARTICLE; BLOOD CULTURE; BRAIN HEMORRHAGE; CHORIOAMNIONITIS; CHRONIC LUNG DISEASE; COMPUTERIZED PROVIDER ORDER ENTRY; CONTROLLED STUDY; DECISION MAKING; DECISION SUPPORT SYSTEM; EOSINOPENIA; FEVER; FUNGUS; GESTATIONAL AGE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; INFANT; LEUKOCYTE COUNT; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MEDICATION COMPLIANCE; NECROTIZING ENTEROCOLITIS; NEUTROPENIA; NEUTROPHIL COUNT; PATENT DUCTUS ARTERIOSUS; PHLEBOTOMY; PRACTICE GUIDELINE; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURITY; PROTOCOL COMPLIANCE; SEPSIS; TREATMENT DURATION; VERY LOW BIRTH WEIGHT;

ALGORITHMS; ANTI-BACTERIAL AGENTS; C-REACTIVE PROTEIN; DECISION SUPPORT TECHNIQUES; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, VERY LOW BIRTH WEIGHT; MALE; RETROSPECTIVE STUDIES; SEPSIS;

EID: 84892927824     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078602     Document Type: Article

References (42)

1. Clark RH, Bloom BT, Spitzer AR, Gerstmann DR (2006) Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics 117: 1979-1987.
2. Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG (2008) Changing patterns in neonatal Escherichia coli sepsis and ampicillin resistance in the era of intrapartum antibiotic prophylaxis. Pediatrics 121: 689-696.
3. Gerdes JS, Polin RA (1987) Sepsis screen in neonates with evaluation of plasma fibronectin. Pediatr Infect Dis J 6: 443-446.
4. Hammerschlag MR, Klein JO, Herschel M, Chen FC, Fermin R (1977) Patterns of use of antibiotics in two newborn nurseries. N Engl J Med 296: 1268-1269.
5. Philip AG, Hewitt JR (1980) Early diagnosis of neonatal sepsis. Pediatrics 65: 1036-1041.
6. Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, et al. (2009) Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics 123: 58-66.
7. Bernard PA (1981) Freedom from ototoxicity in aminoglycoside treated neonates: a mistaken notion. Laryngoscope 91: 1985-1994.
8. Stavroulaki P, Apostolopoulos N, Dinopoulou D, Vossinakis I, Tsakanikos M, et al. (1999) Otoacoustic emissions - an approach for monitoring aminoglycoside induced ototoxicity in children. Int J Pediatr Otorhinolaryngol 50: 177-184.
9. Patel SJ, Saiman L (2010) Antibiotic resistance in neonatal intensive care unit pathogens: mechanisms, clinical impact, and prevention including antibiotic stewardship. Clin Perinatol 37: 547-563.
10. Franz AR, Bauer K, Schalk A, Garland SM, Bowman ED, et al. (2004) Measurement of interleukin 8 in combination with C-reactive protein reduced unnecessary antibiotic therapy in newborn infants: a multicenter, randomized, controlled trial. Pediatrics 114: 1-8.
11. Franz AR, Steinbach G, Kron M, Pohlandt F (1999) Reduction of unnecessary antibiotic therapy in newborn infants using interleukin-8 and C-reactive protein as markers of bacterial infections. Pediatrics 104: 447-453.
12. Benitz WE, Han MY, Madan A, Ramachandra P (1998) Serial serum C-reactive protein levels in the diagnosis of neonatal infection. Pediatrics 102: E41.
13. Weitkamp JH, Aschner JL (2005) Diagnostic use of C-reactive protein (CRP) in assessment of neonatal sepsis. Neoreviews 6: e508-515.
14. Longhurst CA, Parast L, Sandborg CI, Widen E, Sullivan J, et al. (2010) Decrease in hospital-wide mortality rate after implementation of a commercially sold computerized physician order entry system. Pediatrics 126: 14-21.
15. Weitkamp JH, Ozdas A, LaFleur B, Potts AL (2008) Fluconazole prophylaxis for prevention of invasive fungal infections in targeted highest risk preterm infants limits drug exposure. J Perinatol 28: 405-411.
16. Taylor JA, Loan LA, Kamara J, Blackburn S, Whitney D (2008) Medication administration variances before and after implementation of computerized physician order entry in a neonatal intensive care unit. Pediatrics 121: 123-128.
17. Ozdas A, Speroff T, Waitman LR, Ozbolt J, Butler J, et al. (2006) Integrating "best of care" protocols into clinicians' workflow via care provider order entry: impact on quality-of-care indicators for acute myocardial infarction. J Am Med Inform Assoc 13: 188-196.
18. Polin RA (2012) Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics 129: 1006-1015.
19. Fanaroff AA, Korones SB, Wright LL, Verter J, Poland RL, et al. (1998) Incidence, presenting features, risk factors and significance of late onset septicemia in very low birth weight infants. The National Institute of Child Health and Human Development Neonatal Research Network. Pediatr Infect Dis J 17: 593-598.
20. Hornik CP, Benjamin DK, Becker KC, Benjamin DK Jr, Li J, et al. (2012) Use of the complete blood cell count in early-onset neonatal sepsis. Pediatr Infect Dis J 31: 799-802.
21. Manroe BL, Weinberg AG, Rosenfeld CR, Browne R (1979) The neonatal blood count in health and disease. I. Reference values for neutrophilic cells. J Pediatr 95: 89-98.
22. Berrington JE, Barge D, Fenton AC, Cant AJ, Spickett GP (2005) Lymphocyte subsets in term and significantly preterm UK infants in the first year of life analysed by single platform flow cytometry. Clin Exp Immunol 140: 289-292.
23. Correa-Rocha R, Perez A, Lorente R, Ferrando-Martinez S, Leal M, et al. (2012) Preterm neonates show marked leukopenia and lymphopenia that are associated with increased regulatory T-cell values and diminished IL-7. Pediatr Res 71: 590-597.
24. Christensen RD, Baer VL, Gordon PV, Henry E, Whitaker C, et al. (2012) Reference ranges for lymphocyte counts of neonates: associations between abnormal counts and outcomes. Pediatrics 129: e1165-1172.
25. Christensen RD, Jensen J, Maheshwari A, Henry E (2010) Reference ranges for blood concentrations of eosinophils and monocytes during the neonatal period defined from over 63 000 records in a multihospital health-care system. J Perinatol 30: 540-545.
26. Pourcyrous M, Bada HS, Korones SB, Baselski V, Wong SP (1993) Significance of serial C-reactive protein responses in neonatal infection and other disorders. Pediatrics 92: 431-435.
27. Savica V, Santoro D, Mazzaglia G, Ciolino F, Monardo P, et al. (2005) L-carnitine infusions may suppress serum C-reactive protein and improve nutritional status in maintenance hemodialysis patients. J Ren Nutr 15: 225-230.
28. Duranay M, Akay H, Yilmaz FM, Senes M, Tekeli N, et al. (2006) Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients. Nephrol Dial Transplant 21: 3211-3214.
29. Hofer N, Muller W, Resch B (2011) Non-infectious conditions and gestational age influence C-reactive protein values in newborns during the first 3 days of life. Clin Chem Lab Med 49: 297-302.
30. Turner MA, Power S, Emmerson AJ (2004) Gestational age and the C reactive protein response. Arch Dis Child Fetal Neonatal Ed 89: F272-273.
31. Kaufman D, Fairchild KD (2004) Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants. Clin Microbiol Rev 17: 638-680.
32. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, et al. (2010) Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 126: 443-456.
33. Kuppala VS, Meinzen-Derr J, Morrow AL, Schibler KR (2011) Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants. J Pediatr 159: 720-725.
34. Alexander VN, Northrup V, Bizzarro MJ (2011) Antibiotic exposure in the newborn intensive care unit and the risk of necrotizing enterocolitis. J Pediatr 159: 392-397.
35. Benitz WE (2010) Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis. Clin Perinatol 37: 421-438.
36. Hornik CP, Benjamin DK, Becker KC, Benjamin DK Jr, Li J, et al. (2012) Use of the complete blood cell count in late-onset neonatal sepsis. Pediatr Infect Dis J 31: 803-807.
37. Gabay C, Kushner I (1999) Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 340: 448-454.
38. Sabel KG, Hanson LA (1974) The clinical usefulness of C-reactive protein (CRP) determinations in bacterial meningitis and septicemia in infancy. Acta Paediatr Scand 63: 381-388.
39. Povoa P, Souza-Dantas VC, Soares M, Salluh JF (2011) C-reactive protein in critically ill cancer patients with sepsis: influence of neutropenia. Crit Care 15: R129.
40. Santolaya ME, Cofre J, Beresi V (1994) C-reactive protein: a valuable aid for the management of febrile children with cancer and neutropenia. Clin Infect Dis 18: 589-595.
41. Norberg A, Christopher NC, Ramundo ML, Bower JR, Berman SA (2003) Contamination rates of blood cultures obtained by dedicated phlebotomy vs intravenous catheter. JAMA 289: 726-729.
42. Graham PL 3rd, Begg MD, Larson E, Della-Latta P, Allen A, et al. (2006) Risk factors for late onset gram-negative sepsis in low birth weight infants hospitalized in the neonatal intensive care unit. Pediatr Infect Dis J 25: 113-117.