Reference ranges for lymphocyte counts of neonates: Associations between abnormal counts and outcomes

Pediatrics

Volumn 129, Issue 5, 2012, Pages

  Christensen, Robert D ^a,b   Baer, Vickie L ^a,b   Gordon, Philip V ^c   Henry, Erick ^a,d   Whitaker, Cody ^d   Andres, Robert L ^a,b,e   Bennett, Sterling T ^f  

^a INTERMOUNTAIN HEALTHCARE   (United States)

^b McKay Dee Hospital Center   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Institute for Healthcare Delivery Research   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^f INTERMOUNTAIN MEDICAL CENTER   (United States)

Author keywords

Diagnosis; Lymphocyte; Outcome; Reference range

Indexed keywords

FRESH FROZEN PLASMA; NITRIC OXIDE;

ABNORMAL LABORATORY RESULT; APGAR SCORE; ARTICLE; BLOOD CELL COUNT; BLOOD TRANSFUSION; BRAIN HEMORRHAGE; CONTROLLED STUDY; CRYOPRECIPITATION; DISEASE ASSOCIATION; ENCEPHALOMALACIA; ERYTHROCYTE COUNT; ERYTHROCYTE TRANSFUSION; FEMALE; GESTATIONAL AGE; HUMAN; INFANT; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NEUROLOGY; NEWBORN; NEWBORN MORTALITY; OUTCOME ASSESSMENT; PATIENT REFERRAL; PERINATAL ASPHYXIA; PRIORITY JOURNAL; REFERENCE VALUE; RETROLENTAL FIBROPLASIA; SEPSIS; THROMBOCYTE TRANSFUSION;

ASPHYXIA NEONATORUM; CEREBRAL VENTRICLES; CROSS-SECTIONAL STUDIES; GESTATIONAL AGE; HOSPITAL MORTALITY; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE, DISEASES; LEUKOMALACIA, PERIVENTRICULAR; LYMPHOCYTE COUNT; NEONATAL SCREENING; OUTCOME ASSESSMENT (HEALTH CARE); REFERENCE VALUES; RETINOPATHY OF PREMATURITY; RETROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; STATISTICS AS TOPIC; UTAH;

EID: 84860548437     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2011-2661     Document Type: Article

References (31)

1. Weinberg AG, Rosenfeld CR, Manroe BL, Browne R. Neonatal blood cell count in health and disease. II. Values for lymphocytes, monocytes, and eosinophils. J Pediatr. 1985;106(3):462-466 (Pubitemid 15140656)
2. van Gent R, van Tilburg CM, Nibbelke EE, et al. Refined characterization and reference values of the pediatric T- and B-cell compartments. Clin Immunol. 2009;133(1):95-107
3. Lee HR, Shin SS, Yoon JH, et al. Complete blood count reference values of donated cord blood from Korean neonates. Korean J Lab Med. 2009;29(3):179-184
4. Bunders M, Cortina-Borja M, Newell ML; European Collaborative Study. Age-related standards for total lymphocyte, CD4+ and CD8+ T cell counts in children born in Europe. Pediatr Infect Dis J. 2005;24(7): 595-600
5. Pérez A, Gurbindo MD, Resino S, Aguarón A, Muñoz-Fernández MA. NK cell increase in neonates from the preterm to the full-term period of gestation. Neonatology. 2007;92 (3):158-163 (Pubitemid 47442992)
6. Sofatzis P, Mexi-Bourna P, Liossis G, et al. Lymphocyte subpopulations in neonatal sepsis. Perinatal Neonatal Med. 1996;1 (suppl 1):215 [A]
7. Godula-Stuglik U, Mazur B, Mikusz G, Torbus T, Tomanek L. Lymphocyte subpopulations in full-term septic neonates. Pediatr Int. 1999;41(5):500-505 (Pubitemid 29480211)
8. Glavina-Durdov M, Springer O, Capkun V, Saratlija-Novaković Z, Rozić D, Barle M. The grade of acute thymus involution in neonates correlates with the duration of acute illness and with the percentage of lymphocytes in peripheral blood smear. Pathological study. Biol Neonate. 2003;83(4):229-234 (Pubitemid 36566272)
9. Naeye RL, Shaffer ML. Postnatal laboratory timers of antenatal hypoxemic-ischemic brain damage. J Perinatol. 2005;25(10): 664-668 (Pubitemid 41486254)
10. Phelan JP, Korst LM, Ahn MO, Martin GI. Neonatal nucleated red blood cell and lymphocyte counts in fetal brain injury. Obstet Gynecol. 1998;91(4):485-489 (Pubitemid 28153030)
11. Naeye RL, Lin HM. Determination of the timing of fetal brain damage from hypoxemia- ischemia. Am J Obstet Gynecol. 2001; 184(2):217-224 (Pubitemid 32141668)
12. Shah V, Beyene J, Shah P, Perlman M. Association between hematologic findings and brain injury due to neonatal hypoxic-ischemic encephalopathy. Am J Perinatol. 2009;26(4):295-302
13. Christensen RD, Henry E, Jopling J, Wiedmeier SE. The CBC: reference ranges for neonates. Semin Perinatol. 2009;33(1):3-11
14. Christensen RD, Henry E, Andres RL, Bennett ST. Reference ranges for blood concentrations of nucleated red blood cells in neonates. Neonatology. 2011;99(4):289-294
15. Jopling J, Henry E, Wiedmeier SE, Christensen RD. Reference ranges for hematocrit and blood hemoglobin concentration during the neonatal period: data from a multihospital health care system. Pediatrics. 2009;123(2). Available at: www.pediatrics.org/cgi/content/ full/123/2/e333
16. Christensen RD, Jopling J, Henry E, Wiedmeier SE. The erythrocyte indices of neonates, defined using data from over 12,000 patients in a multihospital health care system. J Perinatol. 2008;28(1):24-28
17. Schmutz N, Henry E, Jopling J, Christensen RD. Expected ranges for blood neutrophil concentrations of neonates: the Manroe and Mouzinho charts revisited. J Perinatol. 2008;28(4):275-281 (Pubitemid 351493662)
18. Wiedmeier SE, Henry E, Sola-Visner MC, Christensen RD. Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system. J Perinatol. 2009;29(2):130-136
19. Christensen RD, Jensen J, Maheshwari A, Henry E. Reference ranges for blood concentrations of eosinophils and monocytes during the neonatal period defined from over 63 000 records in a multihospital health-care system. J Perinatol. 2010;30(8): 540-545
20. Manual of Operations. Release 13.2. Burlington, VT: Vermont Oxford Network Database; 2009: 55 and 74
21. Geaghan SM. Normal blood values: selected health-associated values for neonatal, pediatric, and adult populations. In: Greer JP, Foerster J, Rodgers GM, et al, eds. Wintrobe's Clinical Hematology, 12th ed. Philadelphia, PA: Wolters Kluwer/Lippincott, Williams & Wilkins; 2009:2584-2594
22. Paraskevas F. Lymphocytes and lymphatic organs. In: Greer JP, Foerster J, Rodgers GM, et al, eds. Wintrobe's Clinical Hematology, 12th ed. Philadelphia, PA: Wolters Kluwer/Lippincott, Williams & Wilkins; 2009: 319-321
23. Jetzek-Zader M, Gudowius S, Feyen O, Stevens M, Lipfert P, Niehues T. A single intravenous dose of prednisolone induces phosphatidylserine externalization, loss of surface marker expression and a 24-h net increase in human peripheral blood lymphocytes ex vivo. Rheumatol Int. 2007;27(7):667-673 (Pubitemid 46625355)
24. Mignini F, Traini E, Tomassoni D, Vitali M, Streccioni V. Leucocyte subset redistribution in a human model of physical stress. Clin Exp Hypertens. 2008;30(8):720-731
25. Anane LH, Edwards KM, Burns VE, et al. Mobilization of gammadelta T lymphocytes in response to psychological stress, exercise, and beta-agonist infusion. Brain Behav Immun. 2009;23(6):823-829
26. Christensen RD, Hill HR. Exercise-induced changes in the blood concentration of leukocyte populations in teenage athletes. Am J Pediatr Hematol Oncol. 1987;9(2):140-142 (Pubitemid 17079233)
27. Squire E, Favara B, Todd J. Diagnosis of neonatal bacterial infection: hematologic and pathologic findings in fatal and nonfatal cases. Pediatrics. 1979;64(1):60-64 (Pubitemid 9182706)
28. Newman TB, Puopolo KM, Wi S, Draper D, Escobar GJ. Interpreting complete blood counts soon after birth in newborns at risk for sepsis. Pediatrics. 2010;126(5):903-909
29. Kayiran SM, Ozbek N, Turan M, Gürakan B. Significant differences between capillary and venous complete blood counts in the neonatal period. Clin Lab Haematol. 2003;25 (1):9-16 (Pubitemid 36246394)
30. Morse EE, Nashed A, Spilove L. Automated differential leukocyte counts. Ann Clin Lab Sci. 1989;19(3):155-160 (Pubitemid 19123908)
31. Stachon A, Segbers E, Holland-Letz T, Kempf R, Hering S, Krieg M. Nucleated red blood cells in the blood of medical intensive care patients indicate increased mortality risk: a prospective cohort study. Crit Care. 2007; 11(3):R62