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Volumn 31, Issue 1, 2014, Pages 67-78

Regorafenib: A review of its use in previously treated patients with progressive metastatic colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN RECEPTOR; ANTIINFECTIVE AGENT; B RAF KINASE; CARBAMAZEPINE; CLARITHROMYCIN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIRTECAN; FLUOROURACIL; IRINOTECAN; ITRACONAZOLE; KETOCONAZOLE; MIDAZOLAM; OMEPRAZOLE; OXALIPLATIN; PHENOBARBITAL; PHENYTOIN; PLACEBO; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN RET; RAF PROTEIN; REGORAFENIB; RIFAMPICIN; ROSIGLITAZONE; STEM CELL FACTOR RECEPTOR; TELITHROMYCIN; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; WARFARIN;

EID: 84892914903     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.1007/s40266-013-0140-6     Document Type: Article
Times cited : (20)

References (42)
  • 2
    • 84862301209 scopus 로고    scopus 로고
    • Beyond bevacizumab: New anti-vegf strategies in colorectal cancer
    • Troiani T, Martinelli E, Orditura M, et al. Beyond bevacizumab: new anti-VEGF strategies in colorectal cancer. Expert Opin Investig Drugs. 2012;21(7):949-59.
    • (2012) Expert Opin Investig Drugs , vol.21 , Issue.7 , pp. 949-959
    • Troiani, T.1    Martinelli, E.2    Orditura, M.3
  • 3
    • 84861539889 scopus 로고    scopus 로고
    • An update on the current and emerging targeted agents in metastatic colorectal cancer
    • Chu E. An update on the current and emerging targeted agents in metastatic colorectal cancer. Clin Colorectal Cancer. 2012; 11(1):1-13.
    • (2012) Clin Colorectal Cancer , vol.11 , Issue.1 , pp. 1-13
    • Chu, E.1
  • 4
    • 17644427902 scopus 로고    scopus 로고
    • American Cancer Society. Accessed 16 May 2013
    • American Cancer Society. Cancer facts and figures. http://www.cancer.org/ acs/groups/content/@epidemiologysurveilance/documents/document/acspc-036845.pdf (2013). Accessed 16 May 2013.
    • (2013) Cancer Facts and Figures
  • 5
    • 37549072095 scopus 로고    scopus 로고
    • version 3.2013.). Accessed 17 May
    • National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: colon cancer, version 3.2013. http://www.nccn.org/professionals/ physician-gls/pdf/colon.pdf(2013). Accessed 17 May 2013.
    • NCCN Clinical Practice Guidelines in Oncology: Colon Cancer
  • 6
    • 40349100704 scopus 로고    scopus 로고
    • Bevacizumab: A review of its use in metastatic colorectal cancer
    • McCormack PL, Keam SJ. Bevacizumab: A review of its use in metastatic colorectal cancer. Drugs. 2008;68(4):487-506.
    • (2008) Drugs , vol.68 , Issue.4 , pp. 487-506
    • Mccormack, P.L.1    Keam, S.J.2
  • 7
    • 36348987149 scopus 로고    scopus 로고
    • Cetuximab: A review of its use in squamous cell carcinoma of the head and neck and metastatic colorectal cancer
    • Blick SKA, Scott LJ. Cetuximab: A review of its use in squamous cell carcinoma of the head and neck and metastatic colorectal cancer. Drugs. 2007;67(17):2585-607.
    • (2007) Drugs , vol.67 , Issue.17 , pp. 2585-2607
    • Blick, S.K.A.1    Scott, L.J.2
  • 8
    • 77952602038 scopus 로고    scopus 로고
    • Panitumumab: A review of its use in metastatic colorectal cancer
    • Keating GM. Panitumumab: A review of its use in metastatic colorectal cancer. Drugs. 2010;70(8):1059-78.
    • (2010) Drugs , vol.70 , Issue.8 , pp. 1059-1078
    • Keating, G.M.1
  • 9
    • 37549072095 scopus 로고    scopus 로고
    • version 4.2013.). Accessed 17 May
    • National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: rectal cancer, version 4.2013. http://www.nccn.org/professionals/ physician-gls/pdf/rectal.pdf(2013). Accessed 17 May 2013.
    • (2013) NCCN Clinical Practice Guidelines in Oncology: Rectal Cancer
  • 10
    • 77955122376 scopus 로고    scopus 로고
    • New strategies in colorectal cancer: Biomarkers of response to epidermal growth factor receptor monoclonal antibodies and potential therapeutic targets in phosphoinositide 3-kinase and mitogen-activated protein kinase pathways
    • Dasari A, Messersmith WA. New strategies in colorectal cancer: biomarkers of response to epidermal growth factor receptor monoclonal antibodies and potential therapeutic targets in phosphoinositide 3-kinase and mitogen-activated protein kinase pathways. Clin Cancer Res. 2010;16:3811-8.
    • (2010) Clin Cancer Res , vol.16 , pp. 3811-3818
    • Dasari, A.1    Messersmith, W.A.2
  • 11
    • 77950672269 scopus 로고    scopus 로고
    • Targeting multiple kinase pathways: A change in paradigm
    • Gossage L, Eisen T. Targeting multiple kinase pathways: A change in paradigm. Clin Cancer Res. 2010;16:1973-8.
    • (2010) Clin Cancer Res , vol.16 , pp. 1973-1978
    • Gossage, L.1    Eisen, T.2
  • 12
    • 33746544343 scopus 로고    scopus 로고
    • New paradigms in anticancer therapy: Targeting multiple signaling pathways with kinase inhibitors
    • Faivre S, Djelloul S, Raymond E. New paradigms in anticancer therapy: targeting multiple signaling pathways with kinase inhibitors. Semin Oncol. 2006;33:407-20.
    • (2006) Semin Oncol , vol.33 , pp. 407-420
    • Faivre, S.1    Djelloul, S.2    Raymond, E.3
  • 13
    • 64249135764 scopus 로고    scopus 로고
    • Novel agents on the horizon for cancer therapy
    • Ma WW, Adjei AA. Novel agents on the horizon for cancer therapy. CA Cancer J Clin. 2009;59:111-37.
    • (2009) CA Cancer J Clin. , vol.59 , pp. 111-137
    • Ma, W.W.1    Adjei, A.A.2
  • 15
    • 84892938397 scopus 로고    scopus 로고
    • Bayer HealthCare Pharmaceuticals Inc. Accessed 24 Jul 2013
    • Bayer HealthCare Pharmaceuticals Inc. Stivarga (regorafenib) tablets: US prescribing information. http://www.accessdata.fda.gov/drugsatfda-docs/label/ 2013/203085s001lbl.pdf (2013). Accessed 24 Jul 2013.
    • (2013) Stivarga (Regorafenib) Tablets: US Prescribing Information
  • 16
    • 85081812203 scopus 로고    scopus 로고
    • Bayer Inc. Stivarga (regorafenib tablets):, Bayer Inc
    • Bayer Inc. Stivarga (regorafenib tablets): Canadian product monograph. Toronto: Bayer Inc.; 2013.
    • (2013) Canadian Product Monograph. Toronto
  • 17
    • 85081812173 scopus 로고    scopus 로고
    • Bayer. Stivarga (regorafenib tablets):, Osaka: Bayer
    • Bayer. Stivarga (regorafenib tablets): Japanese prescribing information. Osaka: Bayer; 2013.
    • (2013) Japanese Prescribing Information
  • 18
    • 84867122727 scopus 로고    scopus 로고
    • Esmo consensus guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making
    • Schmoll H, Van Cutsem E, Stein A, et al. ESMO consensus guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making. Ann Oncol. 2012;23(10):2479-516.
    • (2012) Ann Oncol , vol.23 , Issue.10 , pp. 2479-2516
    • Schmoll, H.1    Van Cutsem, E.2    Stein, A.3
  • 20
    • 84878556100 scopus 로고    scopus 로고
    • Regorafenib for gastrointestinal malignancies: From preclinical data to clinical results of a novel multi-target inhibitor
    • Aprile G, Macerelli M, Giuliani F. Regorafenib for gastrointestinal malignancies: from preclinical data to clinical results of a novel multi-target inhibitor. BioDrugs. 2013;27(3):213-24.
    • (2013) BioDrugs , vol.27 , Issue.3 , pp. 213-224
    • Aprile, G.1    Macerelli, M.2    Giuliani, F.3
  • 21
    • 79954499886 scopus 로고    scopus 로고
    • Regorafenib (bay 73-4506): A new oral multikinase inhibitor of angiogenic, stromaland oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
    • Wilhelm SM, Dumas J, Adnane L, et al. Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromaland oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer. 2011;129(1):245-55.
    • (2011) Int J Cancer , vol.129 , Issue.1 , pp. 245-255
    • Wilhelm, S.M.1    Dumas, J.2    Adnane, L.3
  • 22
    • 84878578497 scopus 로고    scopus 로고
    • Regorafenib (bay 73-4506): Anti-metastatic activity in a mouse model of colorectal cancer [abstract no2337]
    • Mar-4 Apr, Chicago (IL
    • Schmieder R, Ellinghaus P, Scholz A, et al. Regorafenib (BAY 73-4506): anti-metastatic activity in a mouse model of colorectal cancer [abstract no. 2337]. American Association for Cancer Research Annual Meeting; 31 Mar-4 Apr 2012; Chicago (IL).
    • (2012) American Association for Cancer Research Annual Meeting , vol.31
    • Schmieder, R.1    Ellinghaus, P.2    Scholz, A.3
  • 23
    • 84860531989 scopus 로고    scopus 로고
    • A phase i dose-escalation study of regorafenib (bay 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors
    • Mross K, Frost A, Steinbild S, et al. A phase I dose-escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors. Clin Cancer Res. 2012;18(9):2658-67.
    • (2012) Clin Cancer Res , vol.18 , Issue.9 , pp. 2658-2667
    • Mross, K.1    Frost, A.2    Steinbild, S.3
  • 24
    • 84861459479 scopus 로고    scopus 로고
    • Regorafenib (bay 73-4506) in advanced colorectal cancer: A phase i study
    • Strumberg D, Scheulen ME, Schultheis B, et al. Regorafenib (BAY 73-4506) in advanced colorectal cancer: A phase I study. Br J Cancer. 2012;106(11):1722-7.
    • (2012) Br J Cancer , vol.106 , Issue.11 , pp. 1722-1727
    • Strumberg, D.1    Scheulen, M.E.2    Schultheis, B.3
  • 25
    • 84880075006 scopus 로고    scopus 로고
    • Regorafenib inhibits growth, angiogenesis and metastasis in a highly aggressive, orthotopic colon cancer model
    • doi:10. 1158/1535-7163.MCT-12-1162
    • Abou-Elkacem L, Arns S, Brix G, et al. Regorafenib inhibits growth, angiogenesis and metastasis in a highly aggressive, orthotopic colon cancer model. Mol Cancer Ther. 2013. doi:10. 1158/1535-7163.MCT-12-1162.
    • (2013) Mol Cancer Ther
    • Abou-Elkacem, L.1    Arns, S.2    Brix, G.3
  • 26
    • 77952673621 scopus 로고    scopus 로고
    • Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates
    • Loges S, Schmidt T, Carmeliet P. Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates. Gene Can. 2010;1(1):12-25.
    • (2010) Gene Can , vol.1 , Issue.1 , pp. 12-25
    • Loges, S.1    Schmidt, T.2    Carmeliet, P.3
  • 27
    • 85081806336 scopus 로고    scopus 로고
    • Analysis of plasma protein biomarkers from the correct phase iii study of regorafenib for metastatic colorectal cancer [abstract no. 3514]
    • Lenz H-J, Van Cutsem E, Sobrero AF, et al. Analysis of plasma protein biomarkers from the CORRECT phase III study of regorafenib for metastatic colorectal cancer [abstract no. 3514]. J Clin Oncol. 2013;31(15 Suppl).
    • (2013) J Clin Oncol. , vol.31 , Issue.15 SUPPL.
    • Lenz, H.-J.1    Van Cutsem, E.2    Sobrero, A.F.3
  • 28
    • 84866410804 scopus 로고    scopus 로고
    • Regorafenib induces rapid and reversible changes in plasma nitric oxide and endothelin-1
    • de Jesus-Gonzalez N, Robinson E, Penchev R, et al. Regorafenib induces rapid and reversible changes in plasma nitric oxide and endothelin-1. Am J Hypertens. 2012;25(10):1118-23.
    • (2012) Am J Hypertens , vol.25 , Issue.10 , pp. 1118-1123
    • De, J.-G.N.1    Robinson, E.2    Penchev, R.3
  • 30
    • 84899121465 scopus 로고    scopus 로고
    • Regorafenib in japanese patients with solid tumors: Phase i study of safety, efficacy, and pharmacokinetics
    • doi:10.1007/s10637- 013-9953-8
    • Sunakawa Y, Furuse J, Okusaka T, et al. Regorafenib in Japanese patients with solid tumors: phase I study of safety, efficacy, and pharmacokinetics. Invest New Drugs. 2013. doi:10.1007/s10637- 013-9953-8.
    • (2013) Invest New Drugs
    • Sunakawa, Y.1    Furuse, J.2    Okusaka, T.3
  • 31
    • 84878442416 scopus 로고    scopus 로고
    • Regorafenib in combination with folfox or folfiri as first- or second-line treatment of colorectal cancer: Results of a multicenter, phase ib study
    • Schultheis B, Folprecht G, Kuhlmann J, et al. Regorafenib in combination with FOLFOX or FOLFIRI as first- or second-line treatment of colorectal cancer: results of a multicenter, phase Ib study. Ann Oncol. 2013;24(6):1560-7.
    • (2013) Ann Oncol , vol.24 , Issue.6 , pp. 1560-1567
    • Schultheis, B.1    Folprecht, G.2    Kuhlmann, J.3
  • 32
    • 84872921660 scopus 로고    scopus 로고
    • Regorafenib monotherapy for previously treated metastatic colorectal cancer (correct): An international, multicentre, randomised, placebocontrolled, phase 3 trial
    • Grothey A, Van Cutsem E, Sobrero A, et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebocontrolled, phase 3 trial. Lancet. 2013;381(9863):303-12.
    • (2013) Lancet , vol.381 , Issue.9863 , pp. 303-312
    • Grothey, A.1    Van Cutsem, E.2    Sobrero, A.3
  • 33
    • 85081809211 scopus 로고    scopus 로고
    • Phase 3 correct trial of regorafenib in metastatic colorectal cancer (mcrc): Overall survival update [abstract no. Lba18]
    • ixe10
    • Van Cutsem EJD, Grothey A, Sobrero A, et al. Phase 3 CORRECT trial of regorafenib in metastatic colorectal cancer (mCRC): overall survival update [abstract no. LBA18]. Ann Oncol. 2012;23(Suppl 9):ixe10.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL.9
    • Van Cutsem, E.J.D.1    Grothey, A.2    Sobrero, A.3
  • 34
    • 84934960339 scopus 로고    scopus 로고
    • Mutational analysis of biomarker samples from the correct study: Correlating mutation status with clinical response to regorafenib [abstract no. 381]
    • Jeffers M, Van Cutsem E, Sobrero AF, et al. Mutational analysis of biomarker samples from the CORRECT study: correlating mutation status with clinical response to regorafenib [abstract no. 381]. J Clin Oncol. 2013;31(4 Suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.4 SUPPL.
    • Jeffers, M.1    Van, C.E.2    Sobrero, A.F.3
  • 35
    • 85081803604 scopus 로고    scopus 로고
    • Time profile of adverse events (aes) from regorafenib (reg) treatment for metastatic colorectal cancer (mcrc) in the phase iii correct study [abstract no. 3637]
    • Grothey A, Sobrero AF, Siena S, et al. Time profile of adverse events (AEs) from regorafenib (REG) treatment for metastatic colorectal cancer (mCRC) in the phase III CORRECT study [abstract no. 3637]. J Clin Oncol. 2013;31(15 Suppl).
    • (2013) J Clin Oncol , vol.31 , Issue.15 SUPPL.
    • Grothey, A.1    Sobrero, A.F.2    Siena, S.3
  • 37
    • 85081809480 scopus 로고    scopus 로고
    • ClinicalTrials.gov identifier NCT01289821] US National Institutes of Health,Accessed 20 May 2013
    • Bayer. First line treatment of metastatic colorectal cancer with mFOLFOX6 in combination with regorafenib [ClinicalTrials.gov identifier NCT01289821] US National Institutes of Health, ClinicalTrials.gov. http://clinicaltrials.gov/ ct2/show/NCT01289821?term=regorafenib?colorectal?cancer&rank=7 (2012). Accessed 20 May 2013.
    • (2012) First Line Treatment of Metastatic Colorectal Cancer with MFOLFOX6 in Combination with Regorafenib
    • Bayer1
  • 38
    • 85081807557 scopus 로고    scopus 로고
    • FOLFIRI Versus Placebo ?
    • UNC Lineberger Comprehensive Cancer Center. Regorafenib ?, US National Institutes of Health, Accessed 20 May
    • UNC Lineberger Comprehensive Cancer Center. Regorafenib ? FOLFIRI versus placebo ? FOLFIRI as 2nd line Tx in metastatic colorectal cancer [ClinicalTrials.gov identifier NCT01298570] US National Institutes of Health, ClinicalTrials. gov. http://clinicaltrials.gov/ct2/show/NCT01298570?term= regorafenib?colorectal?cancer&rank=3(2013) Accessed 20 May 2013.
    • (2013) FOLFIRI as 2nd Line Tx in Metastatic Colorectal Cancer [ClinicalTrials.gov Identifier NCT01298570]
  • 39
    • 52949128348 scopus 로고    scopus 로고
    • Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib
    • Lacouture ME, Wu S, Robert C, et al. Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib. Oncologist. 2008;13:1001-11.
    • (2008) Oncologist , vol.13 , pp. 1001-1011
    • Lacouture, M.E.1    Wu, S.2    Robert, C.3
  • 40
    • 64049100782 scopus 로고    scopus 로고
    • Search for evidence-based approaches for the prevention and palliation of hand-foot skin reaction (hfsr) caused by multikinase inhibitors (MKIS)
    • Anderson R, Jatoi A, Robert C, et al. Search for evidence-based approaches for the prevention and palliation of hand-foot skin reaction (HFSR) caused by multikinase inhibitors (MKIs). Oncologist. 2009;14:291-302.
    • (2009) Oncologist , vol.14 , pp. 291-302
    • Anderson, R.1    Jatoi, A.2    Robert, C.3
  • 41
    • 77649213517 scopus 로고    scopus 로고
    • Practical considerations in the management of hand-foot skin reaction caused by multikinase inhibitors
    • Wood LS, Lemont H, Jatoi A, et al. Practical considerations in the management of hand-foot skin reaction caused by multikinase inhibitors. Comm Oncol. 2010;7(1):23-9.
    • (2010) Comm Oncol , vol.7 , Issue.1 , pp. 23-29
    • Wood, L.S.1    Lemont, H.2    Jatoi, A.3
  • 42
    • 84895875810 scopus 로고    scopus 로고
    • CONSIGN) [ClinicalTrials.gov identifier NCT01538680] US National Institutes of Health, ClinicalTrials.gov. Accessed 20 May
    • Bayer. Regorafenib in subjects with metastatic colorectal cancer (CRC) who have progressed after standard therapy (CONSIGN) [ClinicalTrials.gov identifier NCT01538680] US National Institutes of Health, ClinicalTrials.gov. http://clinicaltrials.gov/ct2/show/NCT01538680?term=regorafenib?colorectal? cancer&rank=6(2013) Accessed 20 May 2013.
    • (2013) Regorafenib in Subjects with Metastatic Colorectal Cancer (CRC) Who Have Progressed after Standard Therapy
    • Bayer1


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