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Volumn 116, Issue 2, 2014, Pages 183-191

Effects of oral glutamine supplementation on exercise-induced gastrointestinal permeability and tight junction protein expression

Author keywords

Exercise; Permeability; Tight junction

Indexed keywords

DNA BINDING PROTEIN; GLUTAMINE; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR; I KAPPA B; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; TIGHT JUNCTION PROTEIN; TRANSCRIPTION FACTOR;

EID: 84892913547     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00646.2013     Document Type: Article
Times cited : (92)

References (57)
  • 1
    • 84879114381 scopus 로고    scopus 로고
    • Mechanism of IL-1beta modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation
    • Al-Sadi R, Guo S, Ye D, Dokladny K, Alhmoud T, Ereifej L, Said HM, Ma TY. Mechanism of IL-1beta modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation. J Immunol 190:6596-6606, 2013.
    • (2013) J Immunol , vol.190 , pp. 6596-6606
    • Al-Sadi, R.1    Guo, S.2    Ye, D.3    Dokladny, K.4    Alhmoud, T.5    Ereifej, L.6    Said, H.M.7    Ma, T.Y.8
  • 2
    • 78149291807 scopus 로고    scopus 로고
    • IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway
    • Al-Sadi R, Ye D, Said HM, Ma TY. IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway. Am J Pathol 177:2310-2322, 2010.
    • (2010) Am J Pathol , vol.177 , pp. 2310-2322
    • Al-Sadi, R.1    Ye, D.2    Said, H.M.3    Ma, T.Y.4
  • 3
    • 80053918220 scopus 로고    scopus 로고
    • Effects of whole-body heat acclimation on cell injury and cytokine responses in peripheral blood mononuclear cells
    • Amorim F, Yamada P, Robergs R, Schneider S, Moseley P. Effects of whole-body heat acclimation on cell injury and cytokine responses in peripheral blood mononuclear cells. Eur J Appl Physiol 111:1609-1618, 2011.
    • (2011) Eur J Appl Physiol , vol.111 , pp. 1609-1618
    • Amorim, F.1    Yamada, P.2    Robergs, R.3    Schneider, S.4    Moseley, P.5
  • 5
    • 0021327192 scopus 로고
    • A simple enzymatic method for the assay of urinary lactulose
    • Behrens RH, Docherty H, Elia M, Neale G. A simple enzymatic method for the assay of urinary lactulose. Clin Chim Acta 137:361-367, 1984.
    • (1984) Clin Chim Acta , vol.137 , pp. 361-367
    • Behrens, R.H.1    Docherty, H.2    Elia, M.3    Neale, G.4
  • 7
    • 24644468505 scopus 로고    scopus 로고
    • In vivo heat shock protein assembles with septic liver NF-kappaB/I-kappaB complex regulating NF-kappaB activity
    • Chen HW, Kuo HT, Wang SJ, Lu TS, Yang RC. In vivo heat shock protein assembles with septic liver NF-kappaB/I-kappaB complex regulating NF-kappaB activity. Shock 24:232-238, 2005.
    • (2005) Shock , vol.24 , pp. 232-238
    • Chen, H.W.1    Kuo, H.T.2    Wang, S.J.3    Lu, T.S.4    Yang, R.C.5
  • 9
    • 77950358769 scopus 로고    scopus 로고
    • LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: Possible role of NF-kappaB
    • Dokladny K, Lobb R, Wharton W, Ma TY, Moseley PL. LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kappaB. Cell Stress Chaperones 15:153-163, 2010.
    • (2010) Cell Stress Chaperones , vol.15 , pp. 153-163
    • Dokladny, K.1    Lobb, R.2    Wharton, W.3    Ma, T.Y.4    Moseley, P.L.5
  • 10
    • 33644856858 scopus 로고    scopus 로고
    • Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability
    • Dokladny K, Moseley PL, Ma TY. Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability. Am J Physiol Gastrointest Liver Physiol 290:G204-G212, 2006.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Dokladny, K.1    Moseley, P.L.2    Ma, T.Y.3
  • 11
    • 40449135547 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of heat stress-induced up-regulation of occludin protein expression: Regulatory role of heat shock factor-1
    • Dokladny K, Ye D, Kennedy JC, Moseley PL, Ma TY. Cellular and molecular mechanisms of heat stress-induced up-regulation of occludin protein expression: regulatory role of heat shock factor-1. Am J Pathol 172:659-670, 2008.
    • (2008) Am J Pathol , vol.172 , pp. 659-670
    • Dokladny, K.1    Ye, D.2    Kennedy, J.C.3    Moseley, P.L.4    Ma, T.Y.5
  • 12
    • 84878225041 scopus 로고    scopus 로고
    • Regulatory coordination between two major intracellular homeostatic systems: Heat shock response and autophagy
    • Dokladny KZ, Mandell M, Bhattacharya D, Schneider S, Deretic V, Moseley PL. Regulatory coordination between two major intracellular homeostatic systems: heat shock response and autophagy. J Biol Chem 288:14959-14972, 2013.
    • (2013) J Biol Chem , vol.288 , pp. 14959-14972
    • Dokladny, K.Z.1    Mandell, M.2    Bhattacharya, D.3    Schneider, S.4    Deretic, V.5    Moseley, P.L.6
  • 14
    • 0030043414 scopus 로고    scopus 로고
    • Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junctionlike structures
    • Furuse M, Fujimoto K, Sato N, Hirase T, Tsukita S. Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junctionlike structures. J Cell Sci 109:429-435, 1996.
    • (1996) J Cell Sci , vol.109 , pp. 429-435
    • Furuse, M.1    Fujimoto, K.2    Sato, N.3    Hirase, T.4    Tsukita, S.5
  • 16
    • 79953755734 scopus 로고    scopus 로고
    • A review of sex differences in immune function after aerobic exercise
    • Gillum TL, Kuennen MR, Schneider S, Moseley P. A review of sex differences in immune function after aerobic exercise. Exerc Immunol Rev 17:104-121, 2011.
    • (2011) Exerc Immunol Rev , vol.17 , pp. 104-121
    • Gillum, T.L.1    Kuennen, M.R.2    Schneider, S.3    Moseley, P.4
  • 17
    • 33750523632 scopus 로고    scopus 로고
    • NF-kappaB activation by reactive oxygen species: Fifteen years later
    • Gloire G, Legrand-Poels S, Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 72:1493-1505, 2006.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1493-1505
    • Gloire, G.1    Legrand-Poels, S.2    Piette, J.3
  • 18
    • 79957650912 scopus 로고    scopus 로고
    • Glutamine induces heat shock protein 70 expression via O-GlcNAc modification and subsequent increased expression and transcriptional activity of heat shock factor-1
    • Gong J, Jing L. Glutamine induces heat shock protein 70 expression via O-GlcNAc modification and subsequent increased expression and transcriptional activity of heat shock factor-1. Minerva Anestesiol 77:488-495, 2011.
    • (2011) Minerva Anestesiol , vol.77 , pp. 488-495
    • Gong, J.1    Jing, L.2
  • 19
    • 73449137269 scopus 로고    scopus 로고
    • Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity
    • Hamiel CR, Pinto S, Hau A, Wischmeyer PE. Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. Am J Physiol Cell Physiol 297:C1509-C1519, 2009.
    • (2009) Am J Physiol Cell Physiol , vol.297
    • Hamiel, C.R.1    Pinto, S.2    Hau, A.3    Wischmeyer, P.E.4
  • 20
    • 0024593744 scopus 로고
    • Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
    • Hidalgo IJ, Raub TJ, Borchardt RT. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736-749, 1989.
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 21
    • 83755173518 scopus 로고    scopus 로고
    • Glutamine modulates lipopolysaccharide-induced activation of NF-kappaB via the Akt/mTOR pathway in lung epithelial cells
    • Hou YC, Chiu WC, Yeh CL, Yeh SL. Glutamine modulates lipopolysaccharide- induced activation of NF-kappaB via the Akt/mTOR pathway in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 302:L174-L183, 2012.
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.302
    • Hou, Y.C.1    Chiu, W.C.2    Yeh, C.L.3    Yeh, S.L.4
  • 22
    • 0033959186 scopus 로고    scopus 로고
    • Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men
    • Jeukendrup AE, Vet-Joop K, Sturk A, Stegen JH, Senden J, Saris WH, Wagenmakers AJ. Relationship between gastro-intestinal complaints and endotoxaemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clin Sci 98:47-55, 2000.
    • (2000) Clin Sci , vol.98 , pp. 47-55
    • Jeukendrup, A.E.1    Vet-Joop, K.2    Sturk, A.3    Stegen, J.H.4    Senden, J.5    Saris, W.H.6    Wagenmakers, A.J.7
  • 24
    • 0036203963 scopus 로고    scopus 로고
    • A reference interval study of urinary lactulose excretion: A useful test of intestinal permeability in adults
    • Karaeren Z, Akbay A, Demirtas S, Ergüder I, Ozden A. A reference interval study of urinary lactulose excretion: a useful test of intestinal permeability in adults. Turk J Gastroenterol 13:35-39, 2002.
    • (2002) Turk J Gastroenterol , vol.13 , pp. 35-39
    • Karaeren, Z.1    Akbay, A.2    Demirtas, S.3    Ergüder, I.4    Ozden, A.5
  • 25
    • 70449635134 scopus 로고    scopus 로고
    • Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex
    • Kizelsztein P, Komarnytsky S, Raskin I. Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex. J Neuroimmunol 217:28-37, 2009.
    • (2009) J Neuroimmunol , vol.217 , pp. 28-37
    • Kizelsztein, P.1    Komarnytsky, S.2    Raskin, I.3
  • 27
    • 77950344552 scopus 로고    scopus 로고
    • Glutamine attenuates acute lung injury by inhibition of high mobility group box protein-1 expression during sepsis
    • Kwon WY, Suh GJ, Kim KS, Jo YH, Lee JH, Kim K, Jung SK. Glutamine attenuates acute lung injury by inhibition of high mobility group box protein-1 expression during sepsis. Br J Nutr 103:890-898, 2010.
    • (2010) Br J Nutr , vol.103 , pp. 890-898
    • Kwon, W.Y.1    Suh, G.J.2    Kim, K.S.3    Jo, Y.H.4    Lee, J.H.5    Kim, K.6    Jung, S.K.7
  • 28
    • 0035005586 scopus 로고    scopus 로고
    • Gastrointestinal permeability during exercise: Effects of aspirin and energycontaining beverages
    • Lambert GP, Broussard LJ, Mason BL, Mauermann WJ, Gisolfi CV. Gastrointestinal permeability during exercise: effects of aspirin and energycontaining beverages. J Appl Physiol 90:2075-2080, 2001.
    • (2001) J Appl Physiol , vol.90 , pp. 2075-2080
    • Lambert, G.P.1    Broussard, L.J.2    Mason, B.L.3    Mauermann, W.J.4    Gisolfi, C.V.5
  • 30
    • 33845242540 scopus 로고    scopus 로고
    • Oral glutamine ameliorates chemotherapy-induced changes of intestinal permeability and does not interfere with the antitumor effect of chemotherapy in patients with breast cancer: A prospective randomized trial
    • Li Y, Yu Z, Liu F, Tan L, Wu B, Li J. Oral glutamine ameliorates chemotherapy-induced changes of intestinal permeability and does not interfere with the antitumor effect of chemotherapy in patients with breast cancer: a prospective randomized trial. Tumori 92:396-401, 2006.
    • (2006) Tumori , vol.92 , pp. 396-401
    • Li, Y.1    Yu, Z.2    Liu, F.3    Tan, L.4    Wu, B.5    Li, J.6
  • 31
    • 0035742144 scopus 로고    scopus 로고
    • Limited heat-shock protein 72 induction in Caco-2 cells by L-glutamine
    • Lindemann G, Grohs M, Stange EF, Fellermann K. Limited heat-shock protein 72 induction in Caco-2 cells by L-glutamine. Digestion 64:81-86, 2001.
    • (2001) Digestion , vol.64 , pp. 81-86
    • Lindemann, G.1    Grohs, M.2    Stange, E.F.3    Fellermann, K.4
  • 32
    • 33645116785 scopus 로고    scopus 로고
    • NF-kappa B activation as a pathological mechanism of septic shock and inflammation
    • Liu SF, Malik AB. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 290:L622-L645, 2006.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Liu, S.F.1    Malik, A.B.2
  • 33
    • 27744434045 scopus 로고    scopus 로고
    • Effect of oral glutamine administration on bacterial tanslocation, endotoxemia, liver and ileal morphology, and apoptosis in rats with obstructive jaundice
    • Margaritis VG, Filos KS, Michalaki MA, Scopa CD, Spiliopoulou I, Nikolopoulou VN, Vagianos CE. Effect of oral glutamine administration on bacterial tanslocation, endotoxemia, liver and ileal morphology, and apoptosis in rats with obstructive jaundice. World J Surg 29:1329-1334, 2005.
    • (2005) World J Surg , vol.29 , pp. 1329-1334
    • Margaritis, V.G.1    Filos, K.S.2    Michalaki, M.A.3    Scopa, C.D.4    Spiliopoulou, I.5    Nikolopoulou, V.N.6    Vagianos, C.E.7
  • 34
    • 0022540252 scopus 로고
    • Lactulose, 51Cr-labelled ethylenediaminetetra-acetate, L-rhamnose and polyethyleneglycol 400 [corrected] as probe markers for assessment in vivo of human intestinal permeability
    • Maxton DG, Bjarnason I, Reynolds AP, Catt SD, Peters TJ, Menzies IS. Lactulose, 51Cr-labelled ethylenediaminetetra-acetate, L-rhamnose and polyethyleneglycol 400 [corrected] as probe markers for assessment in vivo of human intestinal permeability. Clin Sci 71:71-80, 1986.
    • (1986) Clin Sci , vol.71 , pp. 71-80
    • Maxton, D.G.1    Bjarnason, I.2    Reynolds, A.P.3    Catt, S.D.4    Peters, T.J.5    Menzies, I.S.6
  • 36
    • 67651120134 scopus 로고    scopus 로고
    • The exercise-induced stress response of skeletal muscle, with specific emphasis on humans
    • Morton JP, Kayani AC, McArdle A. The exercise-induced stress response of skeletal muscle, with specific emphasis on humans. Sports Med 39:643-662, 2009.
    • (2009) Sports Med , vol.39 , pp. 643-662
    • Morton, J.P.1    Kayani, A.C.2    McArdle, A.3
  • 37
    • 0031772471 scopus 로고    scopus 로고
    • Heat shock proteins and the inflammatory response
    • Moseley PL. Heat shock proteins and the inflammatory response. Ann NY Acad Sci 856:206-213, 1998.
    • (1998) Ann NY Acad Sci , vol.856 , pp. 206-213
    • Moseley, P.L.1
  • 44
    • 51149090815 scopus 로고    scopus 로고
    • Mild endotoxemia, NF-kappaB translocation, and cytokine increase during exertional heat stress in trained and untrained individuals
    • Selkirk GA, McLellan TM, Wright HE, Rhind SG. Mild endotoxemia, NF-kappaB translocation, and cytokine increase during exertional heat stress in trained and untrained individuals. Am J Physiol Regul Integr Comp Physiol 295:R611-R623, 2008.
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295
    • Selkirk, G.A.1    McLellan, T.M.2    Wright, H.E.3    Rhind, S.G.4
  • 45
    • 34248184997 scopus 로고    scopus 로고
    • Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression
    • Singleton KD, Wischmeyer PE. Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. Am J Physiol Regul Integr Comp Physiol 292:R1839-R1845, 2007.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.292
    • Singleton, K.D.1    Wischmeyer, P.E.2
  • 46
    • 33646084611 scopus 로고    scopus 로고
    • Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia
    • Singleton KD, Wischmeyer PE. Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia. Shock 25:295-299, 2006.
    • (2006) Shock , vol.25 , pp. 295-299
    • Singleton, K.D.1    Wischmeyer, P.E.2
  • 49
    • 12944252176 scopus 로고    scopus 로고
    • Glutamineenriched enteral nutrition in very low birth weight infants. Design of a double-blind randomised controlled trial
    • Van Den Berg A, Van Elburg RM, Twisk JW, Fetter WP. Glutamineenriched enteral nutrition in very low birth weight infants. Design of a double-blind randomised controlled trial. BMC Pediatr 4:17, 2004.
    • (2004) BMC Pediatr , vol.4 , pp. 17
    • Van Den Berg, A.1    Van Elburg, R.M.2    Twisk, J.W.3    Fetter, W.P.4
  • 50
    • 47549119091 scopus 로고    scopus 로고
    • Interleukin-6 markedly decreases skeletal muscle protein turnover and increases nonmuscle amino acid utilization in healthy individuals
    • Van Hall G, Steensberg A, Fischer C, Keller C, Møller K, Moseley P, Pedersen BK. Interleukin-6 markedly decreases skeletal muscle protein turnover and increases nonmuscle amino acid utilization in healthy individuals. J Clin Endocrinol Metab 93:2851-2858, 2008.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2851-2858
    • Van Hall, G.1    Steensberg, A.2    Fischer, C.3    Keller, C.4    Møller, K.5    Moseley, P.6    Pedersen, B.K.7
  • 51
    • 1842739079 scopus 로고    scopus 로고
    • Gastrointestinal profile of symptomatic athletes at rest and during physical exercise
    • Van Nieuwenhoven MA, Brouns F, Brummer RJ. Gastrointestinal profile of symptomatic athletes at rest and during physical exercise. Eur J Appl Physiol 91:429-434, 2004.
    • (2004) Eur J Appl Physiol , vol.91 , pp. 429-434
    • Van Nieuwenhoven, M.A.1    Brouns, F.2    Brummer, R.J.3
  • 53
    • 0018264538 scopus 로고
    • Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine
    • Windmueller HG, Spaeth AE. Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine. J Biol Chem 253:69-76, 1978.
    • (1978) J Biol Chem , vol.253 , pp. 69-76
    • Windmueller, H.G.1    Spaeth, A.E.2
  • 54
    • 0037221363 scopus 로고    scopus 로고
    • Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells
    • Wischmeyer PE, Riehm J, Singleton KD, Ren H, Musch MW, Kahana M, Chang EB. Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. Nutrition 19:1-6, 2003.
    • (2003) Nutrition , vol.19 , pp. 1-6
    • Wischmeyer, P.E.1    Riehm, J.2    Singleton, K.D.3    Ren, H.4    Musch, M.W.5    Kahana, M.6    Chang, E.B.7
  • 55
    • 37549004821 scopus 로고    scopus 로고
    • Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke
    • Zheng Z, Kim JY, Ma H, Lee JE, Yenari MA. Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke. J Cereb Blood Flow Metab 28:53-63, 2008.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 53-63
    • Zheng, Z.1    Kim, J.Y.2    Ma, H.3    Lee, J.E.4    Yenari, M.A.5


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