Rationalisation of the stereochemical outcome of ene-reductase-mediated bioreduction of α,β-difunctionalised alkenes

Journal of Molecular Catalysis B: Enzymatic

Volumn 101, Issue , 2014, Pages 67-72

  Brenna, Elisabetta ^a   Crotti, Michele ^a   Gatti, Francesco G ^a   Manfredi, Alessia ^a   Monti, Daniela ^b   Parmeggiani, Fabio ^a   Pugliese, Andrea ^a   Zampieri, Davila ^a  

^a POLITECNICO DI MILANO   (Italy)

^b CNR   (Italy)

Author keywords

Alkene reduction; Deuterium; Enantioselectivity; Ene reductase; Old Yellow Enzyme

Indexed keywords

BINDING POCKETS; C-C DOUBLE BONDS; ELECTRON WITHDRAWING GROUP; EMPIRICAL MODEL; ENE-REDUCTASE; HYDROGEN BOND INTERACTION; OLD YELLOW ENZYMES; STEREOCHEMICAL ANALYSIS;

ACTIVATION ANALYSIS; CARBON; CHEMICAL ACTIVATION; DEUTERIUM; ENANTIOSELECTIVITY; ENZYMES; HYDROCARBONS; HYDROGEN BONDS;

REDUCTION;

ALKENE; CARBON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ARTICLE; BINDING SITE; CHEMICAL BOND; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; ENANTIOSELECTIVITY; ENZYME BINDING; ENZYME SUBSTRATE; HYDROGEN BOND; STEREOCHEMISTRY;

EID: 84892910240     PISSN: 13811177     EISSN: 18733158     Source Type: Journal    
DOI: 10.1016/j.molcatb.2013.12.020     Document Type: Article

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