Chemoenzymatic asymmetric synthesis of pregabalin precursors via asymmetric bioreduction of β-cyanoacrylate esters using ene-reductases

Journal of Organic Chemistry

Volumn 78, Issue 4, 2013, Pages 1525-1533

  Winkler, Christoph K ^a   Clay, Dorina ^a   Davies, Simon ^b   O'Neill, Pat ^b   McDaid, Paul ^b   Debarge, Sebastien ^b   Steflik, Jeremy ^b   Karmilowicz, Mike ^b   Wong, John W ^b   Faber, Kurt ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC BIOREDUCTION; ASYMMETRIC SYNTHESIS; CYANOACRYLATES; ESTER MOIETIES;

ADHESIVES; ENANTIOMERS; ESTERIFICATION; ESTERS;

ENZYME ACTIVITY;

CYANOACRYLATE DERIVATIVE; ETHYL 3 CYANOBUT 2 ENOATE; ETHYL 3 CYANOBUTANOATE; ETHYL 3 CYANOHEX 2 ENOATE; ETHYL 3 CYANOHEXANOATE; ETHYL 3 CYANOPENT 2 ENOATE; ETHYL 3C YANOPENTANOATE; ETHYL 5 METHYL 3 CYANOHEX 2 ENOA; METHYL 3 CYANO 5 METHYLHEXANOATE; METHYL 5 METHYL 3 CYANOHEX 2 ENOATE; PREGABALIN; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CATALYSIS; DRUG SYNTHESIS; ENANTIOMER; ENZYME SYNTHESIS; HYDROGENATION; ISOMER; NONHUMAN; STEREOCHEMISTRY;

BIOCATALYSIS; CYANOACRYLATES; ESTERS; GAMMA-AMINOBUTYRIC ACID; OXIDOREDUCTASES; STEREOISOMERISM;

EID: 84873964850     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo302484p     Document Type: Article

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