Regulatory Circuits That Enable Proliferation of the Fungus Candida albicans in a Mammalian Host

PLoS Pathogens

Volumn 9, Issue 12, 2013, Pages 1-3

  Pérez, J Christian ^a   Johnson, Alexander D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CARBON; NITROGEN; IRON;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CANDIDA ALBICANS; CELL DIFFERENTIATION; COMMENSALISM; FUNGAL COLONIZATION; FUNGAL VIRULENCE; HUMAN; IMMUNE SYSTEM; IRON OVERLOAD; MICROBIOME; MUCOSAL DISEASE; NONHUMAN; NUTRIENT; ANIMAL; CANDIDIASIS; CELL PROLIFERATION; GENE REGULATORY NETWORK; GENETICS; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INTESTINE; METABOLISM; MICROBIOLOGY; MICROFLORA; PATHOGENICITY; PHYSIOLOGY; REVIEW;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; CELL PROLIFERATION; GENE REGULATORY NETWORKS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTESTINES; IRON; MICROBIOTA;

EID: 84892889712     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003780     Document Type: Article

References (25)

1. Ghannoum MA, Jurevic RJ, Mukherjee PK, Cui F, Sikaroodi M, et al. (2010) Characterization of the oral fungal microbiome (mycobiome) in healthy individuals. PLoS Pathog 6: e1000713 doi:10.1371/journal.ppat.1000713.
2. Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, et al. (2012) Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science 336: 1314-1317.
3. Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE, (2005) Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 43: 5721-5732.
4. Human Microbiome Project Consortium (2012) Structure, function and diversity of the healthy human microbiome. Nature 486: 207-214.
5. Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, et al. (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464: 59-65.
6. Walter J, Ley R, (2011) The human gut microbiome: ecology and recent evolutionary changes. Ann Rev Microbiol 65: 411-429.
7. Fischbach MA, Sonnenburg JL, (2011) Eating for two: how metabolism establishes interspecies interactions in the gut. Cell Host Microbe 10: 336-347.
8. Pérez JC, Kumamoto CA, Johnson AD, (2013) Candida albicans commensalism and pathogenicity are intertwined traits directed by a tightly knit transcriptional regulatory circuit. PLoS Biol 11: e1001510 doi:10.1371/journal.pbio.1001510.
9. Homann OR, Dea J, Noble SM, Johnson AD, (2009) A phenotypic profile of the Candida albicans regulatory network. PLoS Genet 5: e1000783 doi:10.1371/journal.pgen.1000783.
10. Rosenbach A, Dignard D, Pierce JV, Whiteway M, Kumamoto CA, (2010) Adaptations of Candida albicans for growth in the mammalian intestinal tract. Eukaryot Cell 9: 1075-1086.
11. Kamada N, Kim YG, Sham HP, Vallance BA, Puente JL, et al. (2012) Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science 336: 1325-1329.
12. Miret S, Simpson RJ, McKie AT, (2003) Physiology and molecular biology of dietary iron absorption. Annu Rev Nutr 23: 283-301.
13. Martin RB, Savory J, Brown S, Bertholf RL, Wills MR, (1987) Transferrin binding of Al3+ and Fe3+. Clin Chem 33: 405-407.
14. Chen C, Pande K, French SD, Tuch BB, Noble SM, (2011) An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. Cell Host Microbe 10: 118-135.
15. White SJ, Rosenbach A, Lephart P, Nguyen D, Benjamin A, et al. (2007) Self-regulation of Candida albicans population size during GI colonization. PLoS Pathog 3: e184 doi:10.1371/journal.ppat.0030184.
16. Pierce JV, Dignard D, Whiteway M, Kumamoto CA, (2013) Normal adaptation of Candida albicans to the murine gastrointestinal tract requires Efg1p-dependent regulation of metabolic and host defense genes. Eukaryot Cell 12: 37-49.
17. Pierce JV, Kumamoto CA, (2012) Variation in Candida albicans EFG1 expression enables host-dependent changes in colonizing fungal populations. mBio 3: e00117-00112.
18. Cole GT, Halawa AA, Anaissie EJ, (1996) The role of the gastrointestinal tract in hematogenous candidiasis: from the laboratory to the bedside. Clin Infect Dis 22 Suppl 2: S73-88.
19. Miranda LN, van der Heijden IM, Costa SF, Sousa AP, Sienra RA, et al. (2009) Candida colonisation as a source for candidaemia. J Hosp Infect 72: 9-16.
20. Schweizer A, Rupp S, Taylor BN, Rollinghoff M, Schroppel K, (2000) The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans. Mol Microbiol 38: 435-445.
21. Odds FC, (1987) Candida infections: an overview. CRC Cr Rev Microbiol 15: 1-5.
22. Zordan RE, Miller MG, Galgoczy DJ, Tuch BB, Johnson AD, (2007) Interlocking transcriptional feedback loops control white-opaque switching in Candida albicans. PLoS Biol 5: e256 doi:10.1371/journal.pbio.0050256.
23. Nobile CJ, Fox EP, Nett JE, Sorrells TR, Mitrovich QM, et al. (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148: 126-138.
24. Borneman AR, Leigh-Bell JA, Yu H, Bertone P, Gerstein M, et al. (2006) Target hub proteins serve as master regulators of development in yeast. Gene Dev 20: 435-448.
25. Neph S, Stergachis AB, Reynolds A, Sandstrom R, Borenstein E, et al. (2012) Circuitry and dynamics of human transcription factor regulatory networks. Cell 150: 1274-1286.