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Volumn 13, Issue 1, 2014, Pages

CD133 facilitates epithelial-mesenchymal transition through interaction with the ERK pathway in pancreatic cancer metastasis

Author keywords

Cancer metastasis; CD133; Epithelial mesenchymal transition (EMT); ERK1 2; N cadherin; Pancreatic cancer

Indexed keywords

ANIMALS; ANTIGENS, CD; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL MOVEMENT; EPITHELIAL-MESENCHYMAL TRANSITION; GLYCOPROTEINS; HETEROGRAFTS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; PEPTIDES; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84892881387     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-15     Document Type: Article
Times cited : (74)

References (25)
  • 1
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • 10.1056/NEJMra0901557, 20427809
    • Hidalgo M. Pancreatic cancer. N Engl J Med 2010, 362:1605-1617. 10.1056/NEJMra0901557, 20427809.
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 2
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • 10.1038/nrc822, 12189386
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002, 2:442-454. 10.1038/nrc822, 12189386.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 3
    • 84860390076 scopus 로고    scopus 로고
    • Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells
    • 10.1002/jcb.23150, 3155646, 21503965
    • Bao B, Wang Z, Ali S, Kong D, Banerjee S, Ahmad A, Li Y, Azmi AS, Miele L, Sarkar FH. Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells. J Cell Biochem 2011, 112:2296-2306. 10.1002/jcb.23150, 3155646, 21503965.
    • (2011) J Cell Biochem , vol.112 , pp. 2296-2306
    • Bao, B.1    Wang, Z.2    Ali, S.3    Kong, D.4    Banerjee, S.5    Ahmad, A.6    Li, Y.7    Azmi, A.S.8    Miele, L.9    Sarkar, F.H.10
  • 5
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • 10.1016/j.cell.2008.03.027, 2728032, 18485877
    • Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715. 10.1016/j.cell.2008.03.027, 2728032, 18485877.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6    Brooks, M.7    Reinhard, F.8    Zhang, C.C.9    Shipitsin, M.10
  • 6
    • 36349033966 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer
    • 10.1245/s10434-007-9540-3, 17879119
    • Javle MM, Gibbs JF, Iwata KK, Pak Y, Rutledge P, Yu J, Black JD, Tan D, Khoury T. Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer. Ann Surg Oncol 2007, 14:3527-3533. 10.1245/s10434-007-9540-3, 17879119.
    • (2007) Ann Surg Oncol , vol.14 , pp. 3527-3533
    • Javle, M.M.1    Gibbs, J.F.2    Iwata, K.K.3    Pak, Y.4    Rutledge, P.5    Yu, J.6    Black, J.D.7    Tan, D.8    Khoury, T.9
  • 7
    • 84863259132 scopus 로고    scopus 로고
    • DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA
    • 10.1093/carcin/bgs002, 22223849
    • He X, Zheng Z, Li J, Ben Q, Liu J, Zhang J, Ji J, Yu B, Chen X, Su L, et al. DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA. Carcinogenesis 2012, 33:555-562. 10.1093/carcin/bgs002, 22223849.
    • (2012) Carcinogenesis , vol.33 , pp. 555-562
    • He, X.1    Zheng, Z.2    Li, J.3    Ben, Q.4    Liu, J.5    Zhang, J.6    Ji, J.7    Yu, B.8    Chen, X.9    Su, L.10
  • 8
    • 0038386613 scopus 로고    scopus 로고
    • Src family kinases in tumor progression and metastasis
    • 10.1023/A:1023772912750, 12884910
    • Summy JM, Gallick GE. Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev 2003, 22:337-358. 10.1023/A:1023772912750, 12884910.
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 337-358
    • Summy, J.M.1    Gallick, G.E.2
  • 9
    • 82155192617 scopus 로고    scopus 로고
    • CD133/Src axis mediates tumor initiating property and epithelial-mesenchymal transition of head and neck cancer
    • 10.1371/journal.pone.0028053, 3225383, 22140506
    • Chen YS, Wu MJ, Huang CY, Lin SC, Chuang TH, Yu CC, Lo JF. CD133/Src axis mediates tumor initiating property and epithelial-mesenchymal transition of head and neck cancer. PLoS One 2011, 6:e28053. 10.1371/journal.pone.0028053, 3225383, 22140506.
    • (2011) PLoS One , vol.6
    • Chen, Y.S.1    Wu, M.J.2    Huang, C.Y.3    Lin, S.C.4    Chuang, T.H.5    Yu, C.C.6    Lo, J.F.7
  • 10
    • 66149089157 scopus 로고    scopus 로고
    • The stem cell marker CD133 (prominin-1) is phosphorylated on cytoplasmic tyrosine-828 and tyrosine-852 by Src and Fyn tyrosine kinases
    • 10.1021/bi900159d, 19296573
    • Boivin D, Labbe D, Fontaine N, Lamy S, Beaulieu E, Gingras D, Beliveau R. The stem cell marker CD133 (prominin-1) is phosphorylated on cytoplasmic tyrosine-828 and tyrosine-852 by Src and Fyn tyrosine kinases. Biochemistry 2009, 48:3998-4007. 10.1021/bi900159d, 19296573.
    • (2009) Biochemistry , vol.48 , pp. 3998-4007
    • Boivin, D.1    Labbe, D.2    Fontaine, N.3    Lamy, S.4    Beaulieu, E.5    Gingras, D.6    Beliveau, R.7
  • 12
    • 42149158769 scopus 로고    scopus 로고
    • CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer
    • 10.1038/sj.bjc.6604307, 2361715, 18349830
    • Maeda S, Shinchi H, Kurahara H, Mataki Y, Maemura K, Sato M, Natsugoe S, Aikou T, Takao S. CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer. Br J Cancer 2008, 98:1389-1397. 10.1038/sj.bjc.6604307, 2361715, 18349830.
    • (2008) Br J Cancer , vol.98 , pp. 1389-1397
    • Maeda, S.1    Shinchi, H.2    Kurahara, H.3    Mataki, Y.4    Maemura, K.5    Sato, M.6    Natsugoe, S.7    Aikou, T.8    Takao, S.9
  • 13
    • 84858184063 scopus 로고    scopus 로고
    • Establishment of a highly migratory subclone reveals that CD133 contributes to migration and invasion through epithelial-mesenchymal transition in pancreatic cancer
    • 10.1007/s13577-011-0037-9, 22109279
    • Ding Q, Yoshimitsu M, Kuwahata T, Maeda K, Hayashi T, Obara T, Miyazaki Y, Matsubara S, Natsugoe S, Takao S. Establishment of a highly migratory subclone reveals that CD133 contributes to migration and invasion through epithelial-mesenchymal transition in pancreatic cancer. Hum Cell 2012, 25:1-8. 10.1007/s13577-011-0037-9, 22109279.
    • (2012) Hum Cell , vol.25 , pp. 1-8
    • Ding, Q.1    Yoshimitsu, M.2    Kuwahata, T.3    Maeda, K.4    Hayashi, T.5    Obara, T.6    Miyazaki, Y.7    Matsubara, S.8    Natsugoe, S.9    Takao, S.10
  • 14
    • 84872182511 scopus 로고    scopus 로고
    • Pancreatic cancer stem cells: regulatory networks in the tumor microenvironment and targeted therapy
    • 10.1007/s00534-012-0547-1, 22878838
    • Takao S, Ding Q, Matsubara S. Pancreatic cancer stem cells: regulatory networks in the tumor microenvironment and targeted therapy. J Hepatobiliary Pancreat Sci 2012, 19:614-620. 10.1007/s00534-012-0547-1, 22878838.
    • (2012) J Hepatobiliary Pancreat Sci , vol.19 , pp. 614-620
    • Takao, S.1    Ding, Q.2    Matsubara, S.3
  • 15
    • 0033230475 scopus 로고    scopus 로고
    • N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression
    • 10.1083/jcb.147.3.631, 2151177, 10545506
    • Nieman MT, Prudoff RS, Johnson KR, Wheelock MJ. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 1999, 147:631-644. 10.1083/jcb.147.3.631, 2151177, 10545506.
    • (1999) J Cell Biol , vol.147 , pp. 631-644
    • Nieman, M.T.1    Prudoff, R.S.2    Johnson, K.R.3    Wheelock, M.J.4
  • 16
    • 37249030356 scopus 로고    scopus 로고
    • A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer
    • 10.1158/1078-0432.CCR-07-1263, 18056176
    • Gravdal K, Halvorsen OJ, Haukaas SA, Akslen LA. A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer. Clin Cancer Res 2007, 13:7003-7011. 10.1158/1078-0432.CCR-07-1263, 18056176.
    • (2007) Clin Cancer Res , vol.13 , pp. 7003-7011
    • Gravdal, K.1    Halvorsen, O.J.2    Haukaas, S.A.3    Akslen, L.A.4
  • 17
    • 54449085718 scopus 로고    scopus 로고
    • Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers
    • 10.1073/pnas.0807146105, 2567459, 18806226
    • Dumont N, Wilson MB, Crawford YG, Reynolds PA, Sigaroudinia M, Tlsty TD. Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc Natl Acad Sci U S A 2008, 105:14867-14872. 10.1073/pnas.0807146105, 2567459, 18806226.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14867-14872
    • Dumont, N.1    Wilson, M.B.2    Crawford, Y.G.3    Reynolds, P.A.4    Sigaroudinia, M.5    Tlsty, T.D.6
  • 18
    • 78650697066 scopus 로고    scopus 로고
    • Invasion and EMT-associated genes are up-regulated in B viral hepatocellular carcinoma with high expression of CD133-human and cell culture study
    • 10.1016/j.yexmp.2010.10.003, 20969862
    • Na DC, Lee JE, Yoo JE, Oh BK, Choi GH, Park YN. Invasion and EMT-associated genes are up-regulated in B viral hepatocellular carcinoma with high expression of CD133-human and cell culture study. Exp Mol Pathol 2011, 90:66-73. 10.1016/j.yexmp.2010.10.003, 20969862.
    • (2011) Exp Mol Pathol , vol.90 , pp. 66-73
    • Na, D.C.1    Lee, J.E.2    Yoo, J.E.3    Oh, B.K.4    Choi, G.H.5    Park, Y.N.6
  • 19
    • 77954242530 scopus 로고    scopus 로고
    • Molecular circuits of solid tumors: prognostic and predictive tools for bedside use
    • Ferte C, Andre F, Soria JC. Molecular circuits of solid tumors: prognostic and predictive tools for bedside use. Nat Rev ClinOncol 2010, 7:367-380.
    • (2010) Nat Rev ClinOncol , vol.7 , pp. 367-380
    • Ferte, C.1    Andre, F.2    Soria, J.C.3
  • 20
    • 84866245716 scopus 로고    scopus 로고
    • RAF/MEK dependence of KRAS-mutant pancreatic ductal adenocarcinomas
    • 10.1158/2159-8290.CD-12-0308, 22886659
    • Hanrahan AJ, Solit DB. RAF/MEK dependence of KRAS-mutant pancreatic ductal adenocarcinomas. Cancer Discov 2012, 2:666-669. 10.1158/2159-8290.CD-12-0308, 22886659.
    • (2012) Cancer Discov , vol.2 , pp. 666-669
    • Hanrahan, A.J.1    Solit, D.B.2
  • 22
    • 0035102538 scopus 로고    scopus 로고
    • Prominin: a story of cholesterol, plasma membrane protrusions and human pathology
    • 10.1034/j.1600-0854.2001.020202.x, 11247306
    • Corbeil D, Roper K, Fargeas CA, Joester A, Huttner WB. Prominin: a story of cholesterol, plasma membrane protrusions and human pathology. Traffic 2001, 2:82-91. 10.1034/j.1600-0854.2001.020202.x, 11247306.
    • (2001) Traffic , vol.2 , pp. 82-91
    • Corbeil, D.1    Roper, K.2    Fargeas, C.A.3    Joester, A.4    Huttner, W.B.5
  • 23
    • 4944241261 scopus 로고    scopus 로고
    • Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells
    • 10.1182/blood-2004-02-0511, 15231568
    • Giebel B, Corbeil D, Beckmann J, Hohn J, Freund D, Giesen K, Fischer J, Kogler G, Wernet P. Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells. Blood 2004, 104:2332-2338. 10.1182/blood-2004-02-0511, 15231568.
    • (2004) Blood , vol.104 , pp. 2332-2338
    • Giebel, B.1    Corbeil, D.2    Beckmann, J.3    Hohn, J.4    Freund, D.5    Giesen, K.6    Fischer, J.7    Kogler, G.8    Wernet, P.9
  • 24
    • 84865317384 scopus 로고    scopus 로고
    • Glioma stem cell invasion through regulation of the interconnected ERK, integrin alpha6 and N-cadherin signaling pathway
    • 10.1016/j.cellsig.2012.07.002, 22789454
    • Velpula KK, Rehman AA, Chelluboina B, Dasari VR, Gondi CS, Rao JS, Veeravalli KK. Glioma stem cell invasion through regulation of the interconnected ERK, integrin alpha6 and N-cadherin signaling pathway. Cell Signal 2012, 24:2076-2084. 10.1016/j.cellsig.2012.07.002, 22789454.
    • (2012) Cell Signal , vol.24 , pp. 2076-2084
    • Velpula, K.K.1    Rehman, A.A.2    Chelluboina, B.3    Dasari, V.R.4    Gondi, C.S.5    Rao, J.S.6    Veeravalli, K.K.7
  • 25
    • 84876844907 scopus 로고    scopus 로고
    • Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells
    • 10.1073/pnas.1217002110, 3637720, 23569237
    • Wei Y, Jiang Y, Zou F, Liu Y, Wang S, Xu N, Xu W, Cui C, Xing Y, Liu Y. Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells. Proc Natl Acad Sci U S A 2013, 110:6829-6834. 10.1073/pnas.1217002110, 3637720, 23569237.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 6829-6834
    • Wei, Y.1    Jiang, Y.2    Zou, F.3    Liu, Y.4    Wang, S.5    Xu, N.6    Xu, W.7    Cui, C.8    Xing, Y.9    Liu, Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.