Molecular Differences between Chronic and Aggressive Periodontitis

Journal of Dental Research

Volumn 92, Issue 12, 2013, Pages 1081-1088

  Kebschull, M ^a,f   Guarnieri, P ^b   Demmer, R T ^c   Boulesteix, A L ^d   Pavlidis, P ^e   Papapanou, P N ^a  

^a College of Dental Medicine ^*  (United States)

^b Department of Medicine   (United States)

^c Department of Medicine   (United States)

^d UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f UNIVERSITY OF BONN   (Germany)

Author keywords

classification; gene expression; machine learning; microarray analysis; pathogenesis; transcriptome

Indexed keywords

TRANSCRIPTOME;

AGGRESSIVE PERIODONTITIS; ALGORITHM; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; ARTIFICIAL INTELLIGENCE; CHRONIC PERIODONTITIS; CLASSIFICATION; EPITHELIUM; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETICS; GINGIVA; HUMAN; IMMUNOLOGY; MACHINE LEARNING; METABOLISM; METHODOLOGY; MICROARRAY ANALYSIS; PATHOGENESIS; PATHOLOGY; PERIODONTAL DISEASE; PERIODONTAL POCKET; PERIODONTICS; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; PROCEDURES;

CLASSIFICATION; GENE EXPRESSION; MACHINE LEARNING; MICROARRAY ANALYSIS; PATHOGENESIS; TRANSCRIPTOME;

AGGRESSIVE PERIODONTITIS; ALGORITHMS; APOPTOSIS; AREA UNDER CURVE; ARTIFICIAL INTELLIGENCE; CHRONIC PERIODONTITIS; EPITHELIUM; GENE EXPRESSION PROFILING; GINGIVA; HUMANS; MICROARRAY ANALYSIS; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PERIODONTAL POCKET; ROC CURVE; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTOME;

EID: 84892871186     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034513506011     Document Type: Article

References (25)

1. Armitage GC (1999). Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4: 1-6.
2. Armitage GC (2010). Comparison of the microbiological features of chronic and aggressive periodontitis. Periodontol 2000 53: 70-88.
3. Armitage GC Cullinan MP (2010). Comparison of the clinical features of chronic and aggressive periodontitis. Periodontol 2000 53: 12-27.
4. Berglundh T Donati M Zitzmann N (2007). B cells in periodontitis: friends or enemies? Periodontol 2000 45: 51-66.
5. Boulesteix AL Strobl C (2009). Optimal classifier selection and negative bias in error rate estimation: an empirical study on high-dimensional prediction. BMC Med Res Methodol 9: 85.
6. Chaushu S Wilensky A Gur C Shapira L Elboim M Halftek G. (2012). Direct recognition of Fusobacterium nucleatum by the NK cell natural cytotoxicity receptor NKp46 aggravates periodontal disease. PLoS Pathog 8: e1002601.
7. Demmer RT Behle JH Wolf DL Handfield M Kebschull M Celenti R. (2008). Transcriptomes in healthy and diseased gingival tissues. J Periodontol 79: 2112-2124.
8. Dupuy A Simon RM (2007). Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting. J Natl Cancer Inst 99: 147-157.
9. Gentleman RC Carey VJ Bates DM Bolstad B Dettling M Dudoit S. (2004). Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80.
10. Gluck S Yip AY Ng EL (2012). Can we replace the microscope with microarrays for diagnosis, prognosis and treatment of early breast cancer? Expert Opin Ther Targets 16(Suppl 1):17-22.
11. Kebschull M Papapanou PN (2010). The use of gene arrays in deciphering the pathobiology of periodontal diseases. Methods Mol Biol 666: 385-393.
12. Kebschull M Papapanou PN (2011). Periodontal microbial complexes associated with specific cell and tissue responses. J Clin Periodontol 38(Suppl 11):17-27.
13. Kramer B Kebschull M Nowak M Demmer RT Haupt M Korner C. (2013). Role of the NK cell-activating receptor CRACC in periodontitis. Infect Immun 81: 690-696.
14. Merico D Isserlin R Bader GD (2011). Visualizing gene-set enrichment results using the Cytoscape plug-in enrichment map. Methods Mol Biol 781: 257-277.
15. Nowak M Kramer B Haupt M Papapanou PN Kebschull J Hoffmann P. (2013). Activation of invariant NK T cells in periodontitis lesions. J Immunol 190: 2282-2291.
16. Papapanou PN Behle JH Kebschull M Celenti R Wolf DL Handfield M. (2009). Subgingival bacterial colonization profiles correlate with gingival tissue gene expression. BMC Microbiol 9: 221.
17. Prat A Ellis MJ Perou CM (2012). Practical implications of gene-expression-based assays for breast oncologists. Nat Rev Clin Oncol 9: 48-57.
18. Ryder MI (2010). Comparison of neutrophil functions in aggressive and chronic periodontitis. Periodontol 2000 53: 124-137.
19. Shannon P Markiel A Ozier O Baliga NS Wang JT Ramage D. (2003). Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13: 2498-2504.
20. Sigusch BW Wutzler A Nietzsch T Glockmann E (2006). Evidence for a specific crevicular lymphocyte profile in aggressive periodontitis. J Periodontal Res 41: 391-396.
21. Slawski M Daumer M Boulesteix AL (2008). CMA: a comprehensive Bioconductor package for supervised classification with high dimensional data. BMC Bioinformatics 9: 439.
22. Smith M Seymour GJ Cullinan MP (2010). Histopathological features of chronic and aggressive periodontitis. Periodontol 2000 53: 45-54.
23. Smyth GK (2004). Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3:Article3. [Epub 2004 Feb 12, 2004].
24. Stoecklin-Wasmer C Guarnieri P Celenti R Demmer RT Kebschull M Papapanou PN (2012). MicroRNAs and their target genes in gingival tissues. J Dent Res 91: 934-940.
25. Subramanian A Tamayo P Mootha VK Mukherjee S Ebert BL Gillette MA. (2005). Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102: 15545-15550.