Effects of pentoxifylline on TNF-α production by peripheral blood mononuclear cells in patients with nonalcoholic steatohepatitis

Digestive Diseases and Sciences

Volumn 52, Issue 10, 2007, Pages 2520-2524

  Duman, Deniz G ^a   Ozdemir, Filiz ^b   Birben, Esra ^b   Keskin, Ozlem ^b   Ekşioğlu Demiralp, Emel ^a   Celikel, Cigdem ^a   Kalayci, Omer ^b   Kalayci, Cem ^a  

^a MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Fatty liver; Nonalcoholic steatohepatitis; Pentoxifylline; Peripheral blood mononuclear cells; Tnf alpha

Indexed keywords

LIPOPOLYSACCHARIDE; MESSENGER RNA; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER HISTOLOGY; MALE; NONALCOHOLIC FATTY LIVER; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 34548494820     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-9723-y     Document Type: Article

References (14)

1. Bugianesi E, Leone N, Vanni E, Marchesini G, Brunello F, Carucci P, Musso A, Paolis P, Capussotti L, Salizzoni M, Rizzetto M (2002) Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 123:134-140
2. Marchesini G, Brizi M, Bianchi G (2001) Non-alcoholic fatty liver disease. A feature of the metabolic syndrome. Diabetes 50:1844-1850
3. Valenti L, Fracanzani AL, Dongiovanni P, Santorelli G, Branchi A, Taioli E, Fiorelli G, Fargion S (2002) Tumor necrosis factor a promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. Gastroenterology 122:274-280
4. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM (1996) IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF-a and obesity-induced insulin resistance. Science 371:665-668
5. Wigg AJ, Roberts-Thomson IC, Dymock RB, McCarthy PJ, Grose RH, Cummins AG (2001) The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor a in the pathogenesis of non-alcoholic steatohepatitis. Gut 48:206-211
6. Kugelmas M, Hill DB, Vivian B, Marsano L, McClain CJ (2003) Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology 38:413-419
7. Crespo J, Cayon A, Fernandez-Gil P, Hernandez-Guerra M, Mayorga M, Dominguez-Diez A, Fernandez-Escalante JC, Pons-Romero F (2001) Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology 34:1158-1163
8. Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O (2000) Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Gastroenterology 119:1637-1648
9. Satapathy SK, Gang S, Chauhan R, Sakhuja P, Malhotra V, Sharma BC, Sarin SK (2004) Beneficial effects of tumor necrosis factor-α inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis. Am J Gastroenterol 99:1946-1952
10. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR (1999) Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 94:2467-2474
11. Schandené L, Vandenbussche P, Crusiaux A, Alégre ML, Abramowicz D, Dupont E, et al, (1992) Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF a) and interleukin-6 (IL-6) by monocytes and T cells. Immunology 76:30-34
12. Mander T, Hill S, Hughes A, Rawlins P, Clark C, Gammon G, Foxwell B, Moore M (1997) Differential effects on the TNF-α production by pharmacological agents with varying molecular sites of action. Int J Immunopharmac 19:451-462
13. Anonymous (2002) Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines. Am J Physiol Gastrointest Liver Physiol 282:G1-G5
14. Windmeier C, Gressner AM (1997) Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis. Gen Pharmac 29:181-196