The influence of age and gender on motor and non-motor features of early Parkinson's disease: Initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort

Parkinsonism and Related Disorders

Volumn 20, Issue 1, 2014, Pages 99-105

  Szewczyk Krolikowski, Konrad ^a   Tomlinson, Paul ^a   Nithi, Kannan ^e   Wade Martins, Richard ^a,b   Talbot, Kevin ^a,c   Ben Shlomo, Yoav ^a,d   Hu, Michele T M ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e NORTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Cohort study; Epidemiology; Parkinson's disease

Indexed keywords

AGE; ARTICLE; BEHAVIOR DISORDER; CLINICAL FEATURE; COGNITIVE DEFECT; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; ORTHOSTATIC HYPOTENSION; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; REM BEHAVIOR DISORDER; SEXUAL DYSFUNCTION;

COHORT STUDY; EPIDEMIOLOGY; PARKINSON'S DISEASE;

AGE FACTORS; AGE OF ONSET; AGED; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; PHENOTYPE; SEX FACTORS;

EID: 84892787481     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2013.09.025     Document Type: Article

References (30)

1. van Rooden S.M., Colas F., Martinez-Martin P., Visser M., Verbaan D., Marinus J., et al. Clinical subtypes of Parkinson's disease. Mov Disord 2011, 26:51-58.
2. Chaudhuri K.R., Healy D.G., Schapira A.H.V. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol 2006, 5:235-245. National Institute for Clinical Excellence.
3. Alves G., Muller B., Herlofson K., HogenEsch I., Telstad W., Aarsland D., et al. Incidence of Parkinson's disease in Norway: the Norwegian ParkWest study. JNeurol Neurosurg Psychiatry 2009, 80:851-857.
4. Elm J.J. Design innovations and baseline findings in a long-term Parkinson's trial: The national institute of neurological disorders and stroke exploratory trials in Parkinson's Disease Long-Term Study-1. Mov Disord 2012, 27:1513-1521. The NINDS NET-PD Investigators.
5. Parkinson Study Group DATATOP: a multicenter controlled clinical trial in early Parkinson's disease. Parkinson Study Group. Arch Neurol-Chicago 1989, 46:1052-1060.
6. Diederich N.J., Moore C.G., Leurgans S.E., Chmura T.A., Goetz C.G. Parkinson disease with old-age onset: a comparative study with subjects with middle-age onset. Arch Neurol-Chicago 2003, 60:529-533.
7. Wickremaratchi M.M., Knipe M.D.W., Sastry B.S.D., Morgan E., Jones A., Salmon R., et al. The motor phenotype of Parkinson's disease in relation to age at onset. Mov Disord 2011, 26:457-463.
8. Cooper R., Hardy R., Aihie Sayer A., Ben-Shlomo Y., Birnie K., Cooper C., et al. Age and gender differences in physical capability levels from mid-life onwards: the harmonisation and meta-analysis of data from eight UK cohort studies. Plos One 2011, 6:e27899.
9. Levy G. The relationship of Parkinson disease with aging. Arch Neurol-Chicago 2007, 64:1242-1246.
10. la Fuente-Fernandez de R., Schulzer M., Kuramoto L., Cragg J., Ramachandiran N., Au W.L., et al. Age-specific progression of nigrostriatal dysfunction in Parkinson's disease. Ann Neurol 2011, 69:803-810.
11. Voon V., Mehta A.R., Hallett M. Impulse control disorders in Parkinson's disease: recent advances. Curr Opin Neurol 2011, 24:324-330.
12. Sanchez-Ramos J.R., Ortoll R., Paulson G.W. Visual hallucinations associated with Parkinson disease. Arch Neurol-Chicago 1996, 53:1265-1268.
13. Biglan K.M., Holloway R.G., McDermott M.P., Richard I.H. Risk factors for somnolence, edema, and hallucinations in early Parkinson disease. Neurology 2007, 69:187-195. Parkinson Study Group CALM-PD Investigators.
14. Perez-Lloret S., Nègre-Pagès L., Ojero-Senard A., Damier P., Destée A., Tison F., et al. Oro-buccal symptoms (dysphagia, dysarthria, and sialorrhea) in patients with Parkinson's disease: preliminary analysis from the French COPARK cohort. Eur J Neurol 2012, 19:28-37.
15. Cheon S.-M., Ha M.-S., Park M.J., Kim J.W. Nonmotor symptoms of Parkinson's disease: prevalence and awareness of patients and families. Parkinsonism Relat Disord 2008, 14:286-290.
16. Miller N., Allcock L., Hildreth A.J., Jones D., Noble E., Burn D.J. Swallowing problems in Parkinson disease: frequency and clinical correlates. JNeurol Neurosurg Psychiatry 2009, 80:1047-1049.
17. Baba Y., Putzke J.D., Whaley N.R., Wszolek Z.K., Uitti R.J. Gender and the Parkinson's disease phenotype. JNeurol 2005, 252:1201-1205.
18. Solla P., Cannas A., Ibba F.C., Loi F., Corona M., Orofino G., et al. Gender differences in motor and non-motor symptoms among Sardinian patients with Parkinson's disease. JNeurol Sci 2012, 323:33-39.
19. Lavalaye J., Booij J., Reneman L., Habraken J.B., van Royen E.A. Effect of age and gender on dopamine transporter imaging with [123I]FP-CIT SPET in healthy volunteers. Eur J Nucl Med 2000, 27:867-869.
20. Mozley L.H., Gur R.C., Mozley P.D., Gur R.E. Striatal dopamine transporters and cognitive functioning in healthy men and women. Am J Psychiatry 2001, 158:1492-1499.
21. Haaxma C.A.C., Bloem B.R.B., Borm G.F.G., Oyen W.J.G.W., Leenders K.L.K., Eshuis S.S., et al. Gender differences in Parkinson's disease. JNeurol Neurosurg Psychiatry 2007, 78:819-824.
22. Bliwise D.L., Trotti L.M., Greer S.A., Juncos J.J., Rye D.B. Phasic muscle activity in sleep and clinical features of Parkinson disease. Ann Neurol 2010, 68:353-359.
23. Postuma R.B., Gagnon J.-F. Symmetry of Parkinson's disease and REM sleep: one piece of the puzzle. Ann Neurol 2011, 69:905-906.
24. Gómez-Esteban J.C., Tijero B., Ciordia R., Berganzo K., Somme J., Lezcano E., et al. Factors influencing the symmetry of Parkinson's disease symptoms. Clin Neurol Neurosurg 2010, 112:302-305.
25. Nazem S., Siderowf A.D., Duda J.E., Have T.T., Colcher A., Horn S.S., et al. Montreal cognitive assessment performance in patients with Parkinson's disease with 'normal' global cognition according to mini-mental state examination score. JAm Geriatr Soc 2009, 57:304-308.
26. Martinez-Martin P., Falup Pecurariu C., Odin P., Hilten J.J., Antonini A., Rojo-Abuin J.M., et al. Gender-related differences in the burden of non-motor symptoms in Parkinson's disease. JNeurol 2012, 259:1639-1647.
27. Romenets S.R., Gagnon J.-F., Latreille V., Panniset M., Chouinard S., Montplaisir J., et al. Rapid eye movement sleep behavior disorder and subtypes of Parkinson's disease. Mov Disord 2012, 27:996-1003.
28. Vendette M., Gagnon J.F., Decary A., Massicotte-Marquez J., Postuma R.B., Doyon J., et al. REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia. Neurology 2007, 69:1843-1849.
29. Fantini M.L., Farini E., Ortelli P., Zucconi M., Manconi M., Cappa S., et al. Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder. Sleep 2011, 34:619-625.
30. Postuma R.B., Bertrand J.-A., Montplaisir J., Desjardins C., Vendette M., Rios Romenets S., et al. Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: A prospective study. Mov Disord 2012, 27:720-726.