The motor phenotype of Parkinson's disease in relation to age at onset

Movement Disorders

Volumn 26, Issue 3, 2011, Pages 457-463

  Wickremaratchi, Mirdhu M ^a   Knipe, M Duleeka W ^a   Sastry, B S Dwarakanath ^b   Morgan, Elizabeth ^b   Jones, Anne ^b   Salmon, Rachel ^a   Weiser, Richard ^c   Moran, Maralyn ^c   Davies, Debbie ^d   Ebenezer, Louise ^e   Raha, Sandip ^e   Robertson, Neil P ^a   Butler, Christopher C ^a   Ben Shlomo, Yoav ^f   Morris, Huw R ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^c Gorseinon Hospital   (United Kingdom)

^d ROYAL GWENT HOSPITAL   (United Kingdom)

^e PRINCESS OF WALES HOSPITAL   (United Kingdom)

^f UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Age at onset; Early onset; Motor symptoms; Parkinson's disease; Young onset

Indexed keywords

LEVODOPA;

ADULT; AGE DISTRIBUTION; AGED; AGING; ARTICLE; CLINICAL FEATURE; COMPARATIVE STUDY; CONFOUNDING VARIABLE; CONTROLLED STUDY; DISEASE DURATION; DYSKINESIA; DYSTONIA; FEMALE; GENE; GENE MUTATION; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PARKINSON DISEASE; PHENOTYPE; PINK1 GENE; PREDICTOR VARIABLE; PRIORITY JOURNAL; TREATMENT DURATION;

ADULT; AGE FACTORS; AGE OF ONSET; AGED; AGED, 80 AND OVER; COHORT STUDIES; DYSKINESIAS; DYSTONIA; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MOTOR ACTIVITY; PARKINSON DISEASE; PHENOTYPE; PREVALENCE; SEVERITY OF ILLNESS INDEX;

EID: 79953278055     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.23469     Document Type: Article

References (23)

1. Lewis SJ, Foltynie T, Blackwell AD, Robbins TW, Owen AM, Barker RA. Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach. J Neurol Neurosurg Psychiatry 2005; 76: 343-348.
2. Gomez Arevalo G, Jorge R, Garcia S, Scipioni O, Gershanik O. Clinical and pharmacological differences in early- versus late-onset Parkinson's disease. Mov Disord 1997; 12: 277-284.
3. Quinn N, Critchley P, Marsden CD. Young onset Parkinson's disease. Mov Disord 1987; 2: 73-91.
4. Schrag A, Ben-Shlomo Y, Brown R, Marsden CD, Quinn N. Young-onset Parkinson's disease revisited--clinical features, natural history, and mortality. Mov Disord 1998; 13: 885-894.
5. Golbe LI. Young-onset Parkinson's disease: a clinical review. Neurology 1991; 41: 168-173.
6. Wickremaratchi MM, Perera D, O'Loghlen C, et al. Prevalence and age of onset of Parkinson's disease in Cardiff: a community based cross sectional study and meta-analysis. J Neurol Neurosurg Psychiatry 2009; 80: 805-807.
7. Wickremaratchi MM, Ben-Shlomo Y, Morris HR. The effect of onset age on the clinical features of Parkinson's disease. Eur J Neurol 2009; 16: 450-456.
8. Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988; 51: 745-752.
9. Royston P, Ambler G, Sauerbrei W. The use of fractional polynomials to model continuous risk variables in epidemiology. Int J Epidemiol 1999; 28: 964-974.
10. Lohmann E, Thobois S, Lesage S, et al. A multidisciplinary study of patients with early-onset PD with and without parkin mutations. Neurology 2009; 72: 110-116.
11. Friedman A. Old-onset Parkinson's disease compared with young-onset disease: clinical differences and similarities. Acta Neurol Scand 1994; 89: 258-261.
12. Hely MA, Morris JG, Reid WG, et al. Age at onset: the major determinant of outcome in Parkinson's disease. Acta Neurol Scand 1995; 92: 455-463.
13. Giovannini P, Piccolo I, Genitrini S, et al. Early-onset Parkinson's disease. Mov Disord 1991; 6: 36-42.
14. Scherfler C, Khan NL, Pavese N, et al. Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism. Brain 2004; 127: 1332-1342.
15. Sasaki S, Shirata A, Yamane K, Iwata M. Parkin-positive autosomal recessive juvenile Parkinsonism with alpha-synuclein-positive inclusions. Neurology 2004; 63: 678-682.
16. Tanner CM, Kinori I, Goertz CG, Carvey PM, Klawans HL. Clinical course in Parkinson's disease: relationship to age at onset. J Neurology 1985; 232: 25.
17. Gibb WR, Lees AJ. A comparison of clinical and pathological features of young- and old-onset Parkinson's disease. Neurology 1988; 38: 1402-1406.
18. Gershanik OS, Nygaard TG. Parkinson's disease beginning before age 40. Adv Neurol 1990; 53: 251-258.
19. Kidron D, Melamed E. Forms of dystonia in patients with Parkinson's disease. Neurology 1987; 37: 1009-1011.
20. Ahlskog JE, Muenter MD. Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov Disord 2001; 16: 448-458.
21. Schrag A, Quinn N. Dyskinesias and motor fluctuations in Parkinson's disease. A community-based study. Brain 2000; 123: 2297-2305.
22. Kumar N, Van Gerpen JA, Bower JH, Ahlskog JE. Levodopa-dyskinesia incidence by age of Parkinson's disease onset. Mov Disord 2005; 20: 342-344.
23. Van Den Eeden SK, Tanner CM, Bernstein AL, et al. Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity. Am J Epidemiol 2003; 157: 1015-1022.