High-grade endometrial cancer: Revisiting the impact of tumor size and location on outcomes

Gynecologic Oncology

Volumn 132, Issue 1, 2014, Pages 44-49

  Doll, Kemi M ^a   Tseng, Jill ^b   Denslow, Sheri A ^c   Fader, Amanda Nickles ^b   Gehrig, Paola A ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b GREATER BALTIMORE MEDICAL CENTER   (United States)

^c Health Research Group   (United States)

Author keywords

Endometrial cancer; Lower uterine segment; Nodal disease; Prognostic factors; Tumor size

Indexed keywords

ADULT; AGED; ARTICLE; CARCINOSARCOMA; CLEAR CELL CARCINOMA; COHORT ANALYSIS; DISEASE SEVERITY; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CANCER; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; MIDDLE AGED; MULTICENTER STUDY; OUTCOME ASSESSMENT; PREDICTOR VARIABLE; PRIORITY JOURNAL; RECURRENT DISEASE; RETROSPECTIVE STUDY; TUMOR VOLUME;

ENDOMETRIAL CANCER; LOWER UTERINE SEGMENT; NODAL DISEASE; PROGNOSTIC FACTORS; TUMOR SIZE;

AGED; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM RECURRENCE, LOCAL; RETROSPECTIVE STUDIES;

EID: 84892782536     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2013.10.023     Document Type: Article

References (20)

1. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics, 2012 CA Cancer J Clin 62 1 2012 10 29
2. H.M. Keys, J.A. Roberts, V.L. Brunetto, R.J. Zaino, N.M. Spirtos, and J.D. Bloss et al. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study Gynecol Oncol 92 3 2004 744 751
3. C. Shah, E.B. Johnson, E. Everett, H. Tamimi, B. Greer, and E. Swisher et al. Does size matter? Tumor size and morphology as predictors of nodal status and recurrence in endometrial cancer Gynecol Oncol 99 3 2005 564 570
4. J.C. Schink, A.W. Rademaker, D.S. Miller, and J.R. Lurain Tumor size in endometrial cancer Cancer 67 11 1991 2791 2794
5. O. Lavie, L. Uriev, M. Gdalevich, F. Barak, G. Peer, and R. Auslender et al. The outcome of patients with stage I endometrial cancer involving the lower uterine segment Int J Gynecol Cancer 18 5 2008 1079 1083
6. O. Gemer, M. Gdalevich, M. Voldarsky, F. Barak, A. Ben Arie, and D. Schneider et al. Lower uterine segment involvement is associated with adverse outcome in patients with stage I endometrioid endometrial cancer: results of a multicenter study Eur J Surg Oncol 35 8 2009 865 869
7. A.K. Brown, L. Madom, R. Moore, C.O. Granai, and P. DiSilvestro The prognostic significance of lower uterine segment involvement in surgically staged endometrial cancer patients with negative nodes Gynecol Oncol 105 1 2007 55 58
8. L.M. Madom, A.K. Brown, F. Lui, R.G. Moore, C.O. Granai, and P.A. Disilvestro Lower uterine segment involvement as a predictor for lymph node spread in endometrial carcinoma Gynecol Oncol 107 1 2007 75 78
9. P.W. Grigsby, C.A. Perez, A. Kuten, J.R. Simpson, D.M. Garcia, and H.M. Camel et al. Clinical stage I endometrial cancer: prognostic factors for local control and distant metastasis and implications of the new FIGO surgical staging system Int J Radiat Oncol Biol Phys 22 5 1992 905 911
10. N.A. Mayr, B.C. Wen, J.A. Benda, J.I. Sorosky, C.S. Davis, and R.W. Fuller et al. Postoperative radiation therapy in clinical stage I endometrial cancer: corpus, cervical, and lower uterine segment involvement - patterns of failure Radiology 196 2 1995 323 328
11. C. Irwin, W. Levin, A. Fyles, M. Pintilie, L. Manchul, and P. Kirkbride The role of adjuvant radiotherapy in carcinoma of the endometrium - results in 550 patients with pathologic stage I disease Gynecol Oncol 70 2 1998 247 254
12. A. Semaan, I. Mert, A.R. Munkarah, S. Bandyopadhyay, H.S. Mahdi, and I.S. Winer et al. Clinical and pathologic characteristics of serous carcinoma confined to the endometrium: a multi-institutional study Int J Gynecol Pathol 32 2 2013 181 187
13. A.A. Secord, L.J. Havrilesky, D.M. O'Malley, V. Bae-Jump, N.D. Fleming, and G. Broadwater et al. A multicenter evaluation of sequential multimodality therapy and clinical outcome for the treatment of advanced endometrial cancer Gynecol Oncol 114 3 2009 442 447
14. E.C. Rossi, A. Ivanova, and J.F. Boggess Robotically assisted fluorescence-guided lymph node mapping with ICG for gynecologic malignancies: a feasibility study Gynecol Oncol 124 1 2012 78 82 [Epub 2011/10/15]
15. A.S. Bats, D. Clement, F. Larousserie, M.A. Le Frere-Belda, N. Pierquet-Ghazzar, and C. Hignette et al. Does sentinel node biopsy improve the management of endometrial cancer? Data from 43 patients J Surg Oncol 97 2 2008 141 145 [Epub 2007/12/01]
16. M. Frumovitz, D.C. Bodurka, R.R. Broaddus, R.L. Coleman, A.K. Sood, and D.M. Gershenson et al. Lymphatic mapping and sentinel node biopsy in women with high-risk endometrial cancer Gynecol Oncol 104 1 2007 100 103 [Epub 2006/09/12]
17. E.C. Rossi Determining the sensitivity of sentinel lymph nodes identified with robotic florescence, imaging 2012 [NCT01673022. clinicaltrials.gov2012]
18. A. Mariani, M.J. Webb, G.L. Keeney, M.G. Haddock, G. Calori, and K.C. Podratz Low-risk corpus cancer: is lymphadenectomy or radiotherapy necessary? Am J Obstet Gynecol 182 6 2000 1506 1519
19. P.A. Convery, L.A. Cantrell, N. Di Santo, G. Broadwater, S.C. Modesitt, and A.A. Secord et al. Retrospective review of an intraoperative algorithm to predict lymph node metastasis in low-grade endometrial adenocarcinoma Gynecol Oncol 123 1 2011 65 70
20. I. Winer, H. Mahdi, S. Bandyopadhyay, A. Semaan, K.K. Van de Vijver, and M.R. Nucci et al. Correlation of tumor size with other prognostic factors in uterine serous carcinoma: a large multi-institutional study Gynecol Oncol 128 2 2012 316 321