Low-risk corpus cancer: Is lymphadenectomy or radiotherapy necessary?

American Journal of Obstetrics and Gynecology

Volumn 182, Issue 6, 2000, Pages 1506-1519

  Mariani, Andrea ^a   Webb, Maurice J ^a   Keeney, Gary L ^a   Haddock, Michael G ^a   Calori, Giliola ^b   Podratz, Karl C ^a  

^a MAYO CLINIC   (United States)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Endometrial cancer; Low risk; Lymphadenectomy; Management; Radiotherapy

Indexed keywords

ADULT; AGED; CANCER GRADING; CANCER INVASION; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURVIVAL; CONFERENCE PAPER; ENDOMETRIUM CANCER; FEMALE; HUMAN; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; TREATMENT INDICATION; TUMOR VOLUME;

EID: 0033919275     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/mob.2000.107335     Document Type: Conference Paper

References (32)

1. 1. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics, 2000. CA Cancer J Clin 2000;50:7-33.
2. 2. Elliott P, Green D, Coates A, et al. The efficacy of postoperative vaginal irradiation in preventing vaginal recurrence in endometrial cancer. Int J Gynecol Cancer 1994;4:84-93.
3. 3. Kadar N, Malfetano JH, Homesley HD. Determinants of survival of surgically staged patients with endometrial carcinoma histologically confined to the uterus: implications for therapy. Obstet Gynecol 1992;80:655-9.
4. 4. Morrow CP, Bundy BN, Kurman RJ, Creasman WT, Heller P, Homesley HD, et al. Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a Gynecologic Oncology Group study. Gynecol Oncol 1991;40:55-65.
5. 5. Aalders J, Abeler V, Kolstad P, Onsrud M. Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients. Obstet Gynecol 1980;56:419-27.
6. 5. Carry MS, O'Connell GJ, Johanson CR, Goodyear MD, Murphy KJ. Daya DM, et al. Good outcome associated with a standardized treatment protocol using selective postoperative radiation in patients with clinical stage I adenocarcinoma of the endometrium. Gynecol Oncol 1995;57:138-44.
7. 7. Leijon T, Rosenberg P, Boeryd B. Tolal abdominal hysterectomy and bilateral salpingo-oophorectomy: a sufficient treatment for patients with low risk endometrial carcinoma. Int J Gynecol Cancer 1997;7:376-80.
8. 8. Poulsen HK, Jacobsen M, Bertelsen K, et al. Adjuvant radiation therapy is not necessary in the management of endometrial carcinoma stage I, low-risk cases. Int J Gynecol Cancer 1996;6:38-43.
9. 9. Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer: a Gynecologic Oncology Group study. Cancer 1987;60 Suppl:2035-41.
10. 10. Schink JC, Rademaker AW, Miller DS, Lurain JR. Tumor size in endometrial cancer. Cancer 1991;67:2791-4.
11. 11. Orr JW Jr, Holimon JL, Orr PF. Stage I corpus cancer: is teletherapy necessary? Am J Obstet Gynecol 1997;176:777-88.
12. 12. Lampe B, Kurzl R, Hantschmann P. Prognostic factors that predict pelvic lymph node metastasis from endometrial carcinoma. Cancer 1994;74:2502-8.
13. 13. Burghardt E, Pickel H. Local spread and lymph node involvement in cervical cancer. Obstet Gynecol 1978;52:138-45.
14. 14. Elledge RM, McGuire WL, Osborne CK. Prognostic factors in breast cancer. Semin Oncol 1992;19:244-53.
15. 15. Kamura T, Yahata H, Shigematsu T, Ogawa S, Amada S, Kaku T, et al. Predicting pelvic lymph node metastasis in endometrial carcinoma. Gynecol Oncol 1999;72:387-91.
16. 16. FIGO stages - 1988 revision. Gynecol Oncol 1989;35:125-6.
17. 17. Scully RE, Bonfiglio TA, Kurman RJ, et al. World Health Organization international histologic classification of tumors: histological typing of female genital tract tumors. 2nd ed. Berlin: Springer-Verlag; 1994, p. 13-8.
18. 18. Ferreiro JA, Meyers JL, Bostwick DG. Accuracy of frozen section diagnosis in surgical pathology: review of a 1-year experience with 24,880 cases at Mayo Clinic Rochester. Mayo Clin Proc 1995;70:1137-41.
19. 19. Pavy JJ, Denekamp J, Letschert J, Littbrand B, Mornex F, Bernier J, et al. EORTC Late Effects Working Group. Late effects toxicity scoring: the SOMA scale. Radiother Oncol 1995;35:11-5.
20. 20. Petereit DG, Sarkaria JN, Chappell RJ. Perioperative morbidity and mortality of high-dose-rate gynecologic brachytherapy. Int J Radiat Oncol Biol Phys 1998;42:1025-31.
21. 21. Calais G, Descamps P, Vitu L, Body G, Lansac J, Bougnoux P, et al. Is lymphadenectomy useful in the treatment of endometrial carcinoma? Gynecol Oncol 1990;38:71-5.
22. 22. Eltabbakh GH, Piver MS, Hempling RE, Shin KH. Excellent long-term survival and absence of vaginal recurrences in 332 patients with low-risk stage I endometrial adenocarcinoma treated with hysterectomy and vaginal brachytherapy without formal staging lymph node sampling: report of a prospective trial. Int J Radiat Oncol Biol Phys 1997;38:373-80.
23. 23. Inoue Y, Obata K, Abe K, Ohmura G, Doh K, Yoshioka T, et al. The prognostic significance of vascular invasion by endometrial carcinoma. Cancer 1996;78:1447-51.
24. 24. Larson DM, Connor GP, Broste SK, Krawisz BR, Johnson KK. Prognostic significance of gross myometrial invasion with endometrial cancer. Obstet Gynecol 1996;88:394-8.
25. 25. Shim JU, Rose PG, Reale FR, Soto H, Tak WK, Hunter RE. Accuracy of frozen-section diagnosis at surgery in clinical stage I and II endometrial carcinoma. Am J Obstet Gynecol 1992;166: 1335-8.
26. 26. Weiss E, Hirnle P, Arnold-Bofinger H, Hess CF, Bamberg M. Adjuvant vaginal high-dose-rate afterloading alone in endometrial carcinoma: patterns of relapse and side effects following low-dose therapy. Gynecol Oncol 1998;71:72-6.
27. 27. Sorbe BG, Smeds AC. Postoperative vaginal irradiation with high dose rate afterloading technique in endometrial carcinoma stage I. Int J Radiat Oncol Biol Phys 1990;18:305-14.
28. 28. Lim P, Aquino-Parsons CF, Wong F, Dupuis B, Phillips D, Zhou C, et al. Low-risk endometrial carcinoma: assessment of a treatment policy based on tumor ploidy and identification of additional prognostic indicators. Gynecol Oncol 1999;73:191-5.
29. 29. Larson DM, Broste SK, Krawisz BR. Surgery without radiotherapy for primary treatment of endometrial cancer. Obstet Gynecol 1998;91:355-9.
30. 30. Piver MS, Hempling RE. A prospective trial of postoperative vaginal radium/cesium for grade 1-2 less than 50% myometrial invasion and pelvic radiation therapy for grade 3 or deep myometrial invasion in surgical stage I endometrial adenocarcinoma. Cancer 1990;60:1133-8.
31. 31. Faught W, Krepart GV, Lotocki R, Heywood M. Should selective paraaortic lymphadenectomy be part of surgical staging for endometrial cancer? Gynecol Oncol 1994;55:51-5.
32. 32. Podratz KC, Wilson TO, Gaffey TA, Cha SS, Kauzmann JA. Deoxyribonucleic acid analysis facilitates the pretreatment identification of high-risk endometrial cancer patients. Am J Obstet Gynecol 1993;168:1206-13.