Lower uterine segment involvement is associated with adverse outcome in patients with stage I endometroid endometrial cancer: Results of a multicenter study

European Journal of Surgical Oncology

Volumn 35, Issue 8, 2009, Pages 865-869

  Gemer, O ^a   Gdalevich, M ^b   Voldarsky, M ^a   Barak, F ^a   Ben Arie, A ^c   Schneider, D ^d   Levy, T ^e   Anteby, E Y ^a   Lavie, O ^f  

^a BARZILAI MEDICAL CENTER   (Israel)

^b Epidemiology Research Institute   (Israel)

^c KAPLAN MEDICAL CENTER   (Israel)

^d ASSAF HAROFEH MEDICAL CENTER   (Israel)

^e WOLFSON MEDICAL CENTER   (Israel)

^f CARMEL MEDICAL CENTER   (Israel)

Author keywords

Endometrial cancer; Lower uterine segment; Prognosis

Indexed keywords

ADULT; ADVERSE OUTCOME; AGED; ARTICLE; CANCER CENTER; CANCER MORTALITY; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CLINICAL DECISION MAKING; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOMETRIUM CARCINOMA; ENDOMETROID ENDOMETRIAL CARCINOMA; FEMALE; GYNECOLOGY; HUMAN; HUMAN TISSUE; ISRAEL; MAJOR CLINICAL STUDY; MULTICENTER STUDY; MYOMETRIUM; ONCOLOGY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RISK; RISK FACTOR; SURGICAL TECHNIQUE; UNIVARIATE ANALYSIS; UTERUS;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, ENDOMETRIOID; COHORT STUDIES; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; MIDDLE AGED; PROGNOSIS; RISK; SURVIVAL ANALYSIS; TREATMENT OUTCOME; UTERUS;

EID: 67649289906     PISSN: 07487983     EISSN: 15322157     Source Type: Journal    
DOI: 10.1016/j.ejso.2008.10.007     Document Type: Article

References (19)

1. Aalders J., Abeler V., Kolstad P., and Onsrud M. Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients. Obstet Gynecol 56 (1980) 419-427
2. Morrow C.P., Bundy B.N., Kurman R.J., et al. Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a gynecologic oncology group study. Gynecol Oncol 40 (1991) 55-65
3. Creutzberg C.L., van Putten W.L., Koper P.C., et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC study group. Post operative radiation therapy in endometrial carcinoma. Lancet 355 (2000) 1404-1411
4. Mariani A., Webb M.J., Keeney G.L., Lesnick T.G., and Podratz K.C. Surgical stage I endometrial cancer: predictors of distant failure and death. Gynecol Oncol 87 (2002) 274-280
5. Gemer O., Ben Arie A., Levy T., et al. Lymphvascular space involvement compromises the survival of patients with stage I endometrial cancer: results of a multicenter study. Eur J Surg Oncol 33 (2007) 644-647
6. Grigsby P.W., Perez C.A., Kuten A., et al. Clinical stage I endometrial cancer: prognostic factors for local control and distant metastasis: implications of the new FIGO surgical staging system. Int J Radiat Oncol Biol Phys 22 (1992) 905-911
7. Irwin C., Levin W., Fyles A., Pintile M., Manchul L., and Kirkbride P. The role of adjuvant radiotherapy in carcinoma of the endometrium - results in 550 patients with pathologic stage I disease. Gynecol Oncol 70 (1998) 247-254
8. Madom L.M., Brown A.K., Lui F., Moore R.G., Granai C.O., and Disilvestro P.A. Lower uterine segment involvement as a predictor for lymph node spread in endometrial carcinoma. Gynecol Oncol 107 1 (2007) 75-78
9. DiSaia P.J., Creasman W.T., Boronow R.C., and Blessing J.A. Risk factors and recurrent patterns in stage I endometrial cancer. Am J Obstet Gynecol 151 (1985) 1009-1015
10. Mayr N.A., Wen B.C., Benda J.A., et al. Postoperative radiation therapy in clinical stage I endometrial cancer: corpus, cervical and low uterine segment involvement-patterns of failure. Radiology 196 (1995) 323-328
11. Brown A.K., Madom L., Moore R., Granai C.O., and DiSilvestro P. The prognostic significance of lower uterine segment involvement in surgically staged endometrial cancer patients with negative nodes. Gynecol Oncol 105 1 (2007) 55-58
12. Lavie O., Uriev L., Gdalevich M., et al. The outcome of patients with stage I endometrial cancer involving the lower uterine segment. Int J Gynecol Cancer (2007 Dec 13) [Epub ahead of print]
13. Anderson J.M., Stea B., Hallum A.V., Rogoff E., and Childers J. High-dose-rate postoperative vaginal cuff irradiation alone for stage IB and IC endometrial cancer. Int J Radiat Oncol Biol Phys 46 2 (2000 Jan 15) 417-425
14. Keys H.M., Roberts J.A., Brunetto V.L., et al., Gynecologic Oncology Group. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a gynecologic oncology group study. Gynecol Oncol 92 (2004) 744-751
15. ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer.
16. Phelan C., Montag A.G., Rotmensch J., Waggoner S.E., Yamada S.D., and Mundt A.J. Outcome and management of pathological stage I endometrial carcinoma patients with involvement of the lower uterine segment. Gynecol Oncol 83 3 (2001) 513-517
17. Hamilton C.A., Cheung M.K., Osann K., et al. Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers. Br J Cancer 94 5 (2006) 642-646
18. Hachisuga T., Kaku T., and Enjoji M. Carcinoma of the lower uterine segment. Clinicopathologic analysis of 12 cases. Int J Gynecol Pathol 8 1 (1989) 26-35
19. Axtell A.E., Kelley J.L., Fader A.N., et al. Percent surface area involvement is a predictor of lymph node metastasis in endometrial cancer. Gynecol Oncol 107 (2007) 482-486