Protein biomarkers in vernix with potential to predict the development of atopic eczema in early childhood

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 69, Issue 1, 2014, Pages 104-112

  Holm, T ^a   Rutishauser, D ^b,c   Kai Larsen, Y ^b   Lyutvinskiy, Y ^b   Stenius, F ^b   Zubarev, R A ^b,c   Agerberth, B ^b   Alm, J ^b   Scheynius, A ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SCIENCE FOR LIFE LABORATORY   (Sweden)

Author keywords

atopic eczema; biomarkers; birth cohort; proteomics; vernix

Indexed keywords

ACID CERAMIDASE; ALPHA TROPOMYOSIN; ALPHA4 TROPOMYOSIN; APOLIPOPROTEIN A4; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CALGRANULIN A; CALMODULIN; CALMODULIN LIKE PROTEIN 5; CATHEPSIN D; CATHEPSIN H; CD59 ANTIGEN; DESMOPLAKIN; FILAGGRIN; FILAMIN; FILAMIN B; GANGLIOSIDE GM2 ACTIVATOR PROTEIN; HISTIDINE AMMONIALYASE; INVOLUCRIN; KERATIN TYPE I; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MYOSIN; MYOSIN 9; PEROXIREDOXIN 2; PLECTIN; POLYUBIQUITIN; POLYUBIQUITIN C; PORPHOBILINOGEN SYNTHASE; PSORIASIN; UNCLASSIFIED DRUG; VASPIN;

ARTICLE; ATOPIC DERMATITIS; CHILD; CHILDHOOD; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE COURSE; DISEASE PREDISPOSITION; DOWN REGULATION; ENVIRONMENTAL FACTOR; FEMALE; HUMAN; LIFESTYLE; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TANDEM MASS SPECTROMETRY; VERNIX CASEOSA;

ATOPIC ECZEMA; BIOMARKERS; BIRTH COHORT; PROTEOMICS; VERNIX;

BIOLOGICAL MARKERS; CALCIUM-BINDING PROTEINS; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; POLYUBIQUITIN; PROTEOME; PROTEOMICS; REPRODUCIBILITY OF RESULTS; RISK FACTORS; ROC CURVE; VERNIX CASEOSA;

EID: 84892769430     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12308     Document Type: Article

References (24)

1. Bieber T,. Atopic dermatitis. Ann Dermatol 2010; 22: 125-137.
2. Ballardini N, Kull I, Lind T, Hallner E, Almqvist C, Ostblom E, et al. Development and comorbidity of eczema, asthma and rhinitis to age 12: data from the BAMSE birth cohort. Allergy 2012; 67: 537-544.
3. Gustafsson D, Sjoberg O, Foucard T,. Development of allergies and asthma in infants and young children with atopic dermatitis-a prospective follow-up to 7 years of age. Allergy 2000; 55: 240-245.
4. Bieber T, Cork M, Reitamo S,. Atopic dermatitis: a candidate for disease-modifying strategy. Allergy 2012; 67: 969-975.
5. Alm JS, Swartz J, Lilja G, Scheynius A, Pershagen G,. Atopy in children of families with an anthroposophic lifestyle. Lancet 1999; 353: 1485-1488.
6. Floistrup H, Swartz J, Bergstrom A, Alm JS, Scheynius A, van Hage M, et al. Allergic disease and sensitization in Steiner school children. J Allergy Clin Immunol 2006; 117: 59-66.
7. Stenius F, Swartz J, Lilja G, Borres M, Bottai M, Pershagen G, et al. Lifestyle factors and sensitization in children-the ALADDIN birth cohort. Allergy 2011; 66: 1330-1338.
8. Hoath SB, Pickens WL, Visscher MO,. The biology of vernix caseosa. Int J Cosmet Sci 2006; 28: 319-333.
9. Hoeger PH, Schreiner V, Klaassen IA, Enzmann CC, Friedrichs K, Bleck O,. Epidermal barrier lipids in human vernix caseosa: corresponding ceramide pattern in vernix and fetal skin. Br J Dermatol 2002; 146: 194-201.
10. Williams HC, Burney PG, Hay RJ, Archer CB, Shipley MJ, Hunter JJ, et al. The U.K. working party's diagnostic criteria for atopic dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis. Br J Dermatol 1994; 131: 383-396.
11. Lyutvinskiy Y, Yang H, Rutishauser D, Zubarev R,. In silico instrumental response correction improves precision of label-free proteomics and accuracy of proteomics-based predictive models. Mol Cell Proteomics 2013; 12: 2324-2331.
12. Trygg J, Wold S,. Orthogonal projections to latent structures (O-PLS). J Chemometric 2002; 16: 119-128.
13. Fawcett T,. An introduction to ROC analysis. Pattern Recogn Lett 2006; 27: 861-874.
14. Broadhurst DI, Kella DB,. Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics 2006; 2: 171-196.
15. Tollin M, Jagerbrink T, Haraldsson A, Agerberth B, Jornvall H,. Proteome analysis of vernix caseosa. Pediatr Res 2006; 60: 430-434.
16. Hanna J, Meides A, Zhang DP, Finley D,. A ubiquitin stress response induces altered proteasome composition. Cell 2007; 129: 747-759.
17. Iwai K,. Linear polyubiquitin chains: a new modifier involved in NFkappaB activation and chronic inflammation, including dermatitis. Cell Cycle 2011; 10: 3095-3104.
18. Liu YC, Penninger J, Karin M,. Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol 2005; 5: 941-952.
19. Mehul B, Bernard D, Simonetti L, Bernard MA, Schmidt R,. Identification and cloning of a new calmodulin-like protein from human epidermis. J Biol Chem 2000; 275: 12841-12847.
20. Candi E, Schmidt R, Melino G,. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol 2005; 6: 328-340.
21. Irvine AD, McLean WH, Leung DY,. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 2011; 365: 1315-1327.
22. Szabo-Taylor KE, Eggleton P, Turner CA, Faro ML, Tarr JM, Toth S, et al. Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes. Int J Biochem Cell Biol 2012; 44: 1223-1231.
23. Bergin DA, Hurley K, McElvaney NG, Reeves EP,. Alpha-1 antitrypsin: a potent anti-inflammatory and potential novel therapeutic agent. Arch Immunol Ther Exp (Warsz) 2012; 60: 81-97.
24. Stenius F, Borres M, Bottai M, Lilja G, Lindblad F, Pershagen G, et al. Salivary cortisol levels and allergy in children: the ALADDIN birth cohort. J Allergy Clin Immunol 2011; 128: 1335-1339.