Expansive generation of functional airway epithelium from human embryonic stem cells

Stem Cells Translational Medicine

Volumn 3, Issue 1, 2014, Pages 7-17

  Mcintyre, Brendan A S ^a   Alev, Cantas ^b   Mechael, Rami ^a,c   Salci, Kyle R ^a,c   Lee, Jung Bok ^a   Fiebig Comyn, Aline ^a   Guezguez, Borhane ^a   Wu, Yuping ^b   Sheng, Guojun ^b   Bhatia, Mickie ^a,c  

^a MCMASTER UNIVERSITY   (Canada)

^b RIKEN Center for Biosystems Dynamics Research   (Japan)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Acute lung injury; Air liquid interface; Differentiation; Human embryonic stem cells

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRIC RESISTANCE; EMBRYONIC STEM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE IN SITU HYBRIDIZATION; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; MICROCHIMERISM; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM;

ACUTE LUNG INJURY; AIR-LIQUID INTERFACE; DIFFERENTIATION; HUMAN EMBRYONIC STEM CELLS;

ACUTE LUNG INJURY; ANIMALS; BIOLOGICAL MARKERS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; DISEASE MODELS, ANIMAL; EMBRYONIC STEM CELLS; EPITHELIAL CELLS; HUMANS; LUNG TRANSPLANTATION; MICE; PLURIPOTENT STEM CELLS; RECOVERY OF FUNCTION; RESPIRATORY MUCOSA; TISSUE AND ORGAN HARVESTING; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84892763292     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2013-0119     Document Type: Article

References (43)

1. Zhang D, Jiang W, Liu M et al. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 2009;19:429-438.
2. Cai J, Zhao Y, Liu Y et al. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology 2007;45:1229-1239.
3. Inami Y, Yoshikai T, Ito S et al. Differentiation of induced pluripotent stem cells to thymic epithelial cells by phenotype. Immunol Cell Biol 2011;89:314-321.
4. MouH, ZhaoR, SherwoodRetal. Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell 2012;10:385-397.
5. Kadzik RS, Morrisey EE. Directing lung endoderm differentiation in pluripotent stem cells. Cell Stem Cell 2012;10:355-361.
6. Cheng X, Ying L, Lu L et al. Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. Cell Stem Cell 2012;10:371-384.
7. Longmire TA, Ikonomou L, Hawkins F et al. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell 2012;10:398-411.
8. Green MD, Chen A, Nostro MC et al. Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat Biotechnol 2011;29:267-272.
9. VanHaute L, DeBlockG, Liebaers I et al. Generation of lung epithelial-like tissue from human embryonic stem cells. Respir Res 2009;10:105.
10. WongAP, Bear CE, Chin S et al. Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol 2012;30:876-882.
11. Lung stem cells: Looking beyond the hype. Nat Med 2011;17:788-789.
12. Kroon E, Martinson LA, Kadoya K et al. Pancreatic endoderm derived from human embryonic stem cells generates glucoseresponsive insulin-secreting cells in vivo. Nat Biotechnol 2008;26:443-452.
13. Kelly OG, Chan MY, Martinson LA et al. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nat Biotechnol 2011;29:750-756.
14. Adewumi O, Aflatoonian B, Ahrlund-Richter L et al. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol 2007;25:803-816.
15. Hong SH, Lee JH, Lee JB et al. ID1 and ID3 represent conserved negative regulators of human embryonic and induced pluripotent stem cell hematopoiesis. J Cell Sci 2011;124: 1445-1452.
16. Alev C, WuY, Kasukawa T et al. Transcriptomic landscape of the primitive streak. Development 2010;137:2863-2874.
17. Hamburger V, Hamilton HL. A series of normal stages in the development of the chick embryo. 1951. Dev Dyn 1992;195:231-272.
18. Nakazawa F, Nagai H, ShinMet al. Negative regulation of primitive hematopoiesis by the FGF signaling pathway. Blood 2006;108: 3335-3343.
19. Alev C, Nakano M, WuY et al. Manipulating the avian epiblast and epiblast-derived stem cells. Methods Mol Biol 2013;1074:151-173.
20. Kajstura J, Rota M, Hall SR et al. Evidence for human lung stem cells. N Engl J Med 2011; 364:1795-1806.
21. Imai Y, Kuba K, Rao S et al. Angiotensinconverting enzyme 2 protects from severe acute lung failure. Nature 2005;436:112-116.
22. Luchtel DL, Boykin JC, Bernard SL et al. Histological methods to determine blood flow distribution with fluorescent microspheres. Biotech Histochem 1998;73:291-309.
23. Becker M, Nitsche A, Neumann C et al. Sensitive PCR method for the detection and real-time quantification of human cells in xenotransplantation systems. Br J Cancer 2002;87: 1328-1335.
24. Risueno RM, Sachlos E, Lee JH et al. Inability of human induced pluripotent stem cell-hematopoietic derivatives to downregulate microRNAs in vivo reveals a block in xenograft hematopoietic regeneration. STEM CELLS 2012; 30:131-139.
25. Tada S, Era T, Furusawa C et al. Characterization of mesendoderm: A diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development 2005;132:4363-4374.
26. Trounson A. The production and directed differentiation of human embryonic stem cells. Endocr Rev 2006;27:208-219.
27. YasunagaM, Tada S, Torikai-Nishikawa S et al. Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells. Nat Biotechnol 2005;23: 1542-1550.
28. D'Amour KA, Agulnick AD, Eliazer S et al. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 2005;23:1534-1541.
29. Woodland HR, Zorn AM. The core endodermal gene network of vertebrates: Combining developmental precision with evolutionary flexibility. Bioessays 2008;30:757-765.
30. Hong SH, Rampalli S, Lee JB et al. Cell fate potential of human pluripotent stem cells is encoded by histone modifications. Cell Stem Cell 2011;9:24-36.
31. Ludwig TE, Levenstein ME, JonesJM et al. Derivation of human embryonic stem cells in defined conditions. Nat Biotechnol 2006;24: 185-187.
32. Mizoguchi T, Verkade H, Heath JK et al. Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation. Development 2008;135:2521-2529.
33. Blume LF, Denker M, Gieseler F et al. Temperature corrected transepithelial electrical resistance (TEER) measurement to quantify rapid changes in paracellular permeability. Pharmazie 2010;65:19-24.
34. Tunggal JA, Helfrich I, Schmitz A et al. Ecadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J 2005;24:1146-1156.
35. Ivliev AE, Hoen PA, vanRoon-MomWM et al. Exploring the transcriptome of ciliated cells using in silico dissection of human tissues. PLoS One 2012;7:e35618.
36. El-Hashash AH, Al Alam D, Turcatel G et al. Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol 2011;353:242-258.
37. Besnard V, Wert SE, Kaestner KH et al. Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1. Am J Physiol Lung Cell Mol Physiol 2005;289:L750-L759.
38. Wong CJ, Akiyama J, Allen L et al. Localization and developmental expression of surfactant proteins D and A in the respiratory tract of the mouse. Pediatr Res 1996;39:930-937.
39. Dabbagh K, Takeyama K, LeeHMet al. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol 1999; 162:6233-6237.
40. Martin TR, Frevert CW. Innate immunity in the lungs. Proc Am Thorac Soc 2005;2: 403-411.
41. Wobus AM, Boheler KR. Embryonic stem cells: Prospects for developmental biology and cell therapy. Physiol Rev 2005;85:635-678.
42. Wang D, Haviland DL, Burns AR et al. A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. Proc Natl Acad Sci USA 2007;104: 4449-4454.
43. Lee JW, Fang X, Krasnodembskaya A et al. Concise review: Mesenchymal stem cells for acute lung injury: Role of paracrine soluble factors. STEM CELLS 2011;29:913-919.