The CRE luc bioluminescence transgenic mouse model for detecting ligand activation of GPCRs

Journal of Biomolecular Screening

Volumn 19, Issue 2, 2014, Pages 232-241

  Dressler, Holly ^a   Economides, Kyriakos ^a   Favara, Sarah ^b   Wu, Nancy N ^a   Pang, Zhen ^a   Polites, H Greg ^c  

^a Sanofi NA Research and Development   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c Tucson Research Center   (United States)

Author keywords

bioluminescence; GPCR; luciferase; reporter mouse; transgenic

Indexed keywords

3 ALLYL 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (6 CARBOXYHEXYL) 1 (3 CYCLOHEXYL 3 HYDROXYPROPYL)HYDANTOIN; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CANNABINOID 1 RECEPTOR; CYCLIC AMP; DOPAMINE; DOPAMINE 1 RECEPTOR; EX 00000173A; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; ISOPRENALINE; LIGAND; LIXISENATIDE; LUCIFERASE; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR AGONIST; ROLIPRAM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DRUG RECEPTOR BINDING; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; LUCIFERASE ASSAY; MOLECULAR IMAGING; MOUSE; MOUSE MODEL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENE; TRANSGENIC MOUSE;

BIOLUMINESCENCE; GPCR; LUCIFERASE; REPORTER MOUSE; TRANSGENIC;

ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; LIGANDS; LUMINESCENT MEASUREMENTS; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; RECEPTORS, G-PROTEIN-COUPLED; SMALL MOLECULE LIBRARIES; TRANSCRIPTOME; TRANSFECTION;

EID: 84892758365     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113496465     Document Type: Article

References (16)

1. Luker K. E., Luker G. D. Bioluminescence Imaging of Reporter Mice for Studies of Infection and Inflammation. Antiviral Res. 2010 ; 86: 93-100
2. Bard C. E., Tannous B. A. Bioluminescence Imaging: Progress and Applications. Trends Biotechnol. 2011 ; 29: 624-633
3. Keyaerts M., Caveliers V., Lahoutte T. Bioluminescence Imaging: Looking beyond the Light. Trends Mol. Med. 2012 ; 18: 164-172
4. Hill S. J., Baker J. G., Rees S. Reporter-Gene Systems for the Study of G-Protein-Coupled Receptors. Curr. Opin. Pharmacol. 2001 ; 1: 526-532 (Pubitemid 33593844)
5. Maggi A., Ottobrini L., Biserni A., et al. Technique: Reporter Mice - A New Way to Look at Drug Action. Trends Pharmacol. Sci. 2004 ; 25: 337-342 (Pubitemid 38692427)
6. Zhang W., Purchio A. F., Chen K., et al. A Transgenic Mouse Model with a Luciferase Reporter for Studying Transcriptional Regulation of the Human CYP3A4 Gene. Drug Metab. Dispos. 2003 ; 3: 1054-1064 (Pubitemid 36975677)
7. Gossen J. A., de Leeuw W. J., Tan C. H., et al. Efficient Rescue of Integrated Shuttle Vectors from Transgenic Mice: A Model for Studying Mutations. Proc. Nat. Acad. Sci. U. S. A. 1989 ; 86: 7971-7975 (Pubitemid 19265301)
8. Sacco M. G., Zecca L., Bagnasco L., et al. A Transgenic Mouse Model for the Detection of Cellular Stress Induced by Toxic Inorganic Compounds. Nat. Biotechnol. 1997 ; 15: 1392-1397 (Pubitemid 28022735)
9. Rudin M., Beckmann N., Rausch M. Evaluation of Drug Candidates: Efficacy Readouts during Lead Optimization. Prog. Drug. Res. 2005 ; 62: 185-255 (Pubitemid 41569586)
10. Ray P., Lewin S. A., Mihalko L. A., et al. Noninvasive Imaging Reveals Inhibition of Ovarian Cancer by Targeting CXCL12-CXCR4. Neoplasia. 2011 ; 13: 1152-1161
11. Von Degenfeld G., Wehrman T. S., Hammer M. M., et al. A Universal Technology for Monitoring G-Protein-Coupled Receptor Activation In Vitro and Noninvasively in Live Animals. FASEB J. 2007 ; 21: 3819-3826 (Pubitemid 350232339)
12. Ramachandran B., Stell A., Maravigna L., et al. Novel Insights on Imaging Sex-Hormone-Dependent Tumourigenesis. Endocr. Relat. Cancer. 2011 ; 18: R41 - R51
13. Stell A., Belcredito S., Ciana P., et al. Molecular Imaging Provides Novel Insights on Estrogen Receptor Activity in Mouse Brain. Mol. Imaging. 2008 ; 7: 283-292
14. Polites H. G., Pinkert C. A. Transgenic Animal Technology: A Laboratory Handbook. 2002 ; 2nd ed. Pinkert C. A., ed. New York: Academic Press ; 2002 :
15. Cheng J. B., Watson J. W., Pazoles C. J., et al. The Phosphodiesterase Type 4 (PDE4) Inhibitor CP- 80,633 Elevates Plasma Cyclic AMP Levels and Decreases Tumor Necrosis Factor-Alpha (TNFalpha) Production in Mice: Effect of Adrenalectomy. J. Pharmacol. Exp. Ther. 1997 ; 280: 621-626 (Pubitemid 27171321)
16. Contag P. R., Olomu I. N., Stevenson D. K., et al. Bioluminescent Indicators in Living Mammals. Nat. Med. 1998 ; 4: 245-247 (Pubitemid 28137381)