Establishment of an inflamed animal model of diabetic nephropathy

International Journal of Biological Sciences

Volumn 10, Issue 2, 2014, Pages 149-159

  Ma, Kun Ling ^a   Zhang, Yang ^a   Liu, Jing ^a   Wu, Yu ^a   Hu, Ze Bo ^a   Ruan, Xiong Zhong ^b   Liu, Bi Cheng ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Animal model; Db db mice; Diabetic nephropathy; Inflammation

Indexed keywords

ANIMAL; ANIMAL MODEL; ARTICLE; C57BL MOUSE; DB/DB MICE; DIABETIC NEPHROPATHY; DISEASE MODEL; INFLAMMATION; KIDNEY; MOUSE; PATHOLOGY; PROTEINURIA;

ANIMAL MODEL; DB/DB MICE; DIABETIC NEPHROPATHY; INFLAMMATION;

ANIMALS; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; INFLAMMATION; KIDNEY; MICE; MICE, INBRED C57BL; PROTEINURIA;

EID: 84892695818     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.7875     Document Type: Article

References (18)

1. Ritz E, Rychlik I, Locatelli F, Halimi S. End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions. Am J Kidney Dis 1999; 34(5):795-808.
2. Lim AK, Tesch GH. Inflammation in diabetic nephropathy. Mediators Inflamm 2012; 2012:146154.
3. Duffield JS. Macrophages and immunologic inflammation of the kidney. Semin Nephrol 2010; 30(3):234-254.
4. Ricardo SD, van GH, Eddy AA. Macrophage diversity in renal injury and repair. J Clin Invest 2008; 118(11):3522-3530.
5. Nguyen DV, Shaw LC, Grant MB. Inflammation in the pathogenesis of microvascular complications in diabetes. Front Endocrinol (Lausanne) 2012; 3:170.
6. Festa A, D'Agostino R, Jr., Howard G, Mykkanen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2000; 102(1):42-47.
7. Frohlich M, Imhof A, Berg G, Hutchinson WL, Pepys MB, Boeing H, et al. Association between C-reactive protein and features of the metabolic syndrome: a population-based study. Diabetes Care 2000; 23(12):1835-1839.
8. Pickup JC, Mattock MB, Chusney GD, Burt D. NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 1997; 40(11):1286-1292.
9. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444(7121):860-867.
10. Ma KL, Ruan XZ, Powis SH, Chen Y, Moorhead JF, Varghese Z. Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice. Hepatology 2008; 48(3):770-781.
11. Kang SB, Kim HM, Kim HJ, Seok H, Huh JH, Lee BW, et al. Rosiglitazone attenuates casein-induced hepatic endoplasmic reticulum stress in Sprague-Dawley rats: a novel model of endoplasmic reticulum stress. Endocr J 2013 Aug 20.
12. Ma KL, Liu J, Wang CX, Ni J, Zhang Y, Wu Y, et al. Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation. Cardiovasc Res 2013 Sep 25.
13. Xu ZE, Chen Y, Huang A, Varghese Z, Moorhead JF, Yan F, et al. Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice. Am J Physiol Renal Physiol 2011; 301(4):F713-F722.
14. Breyer MD, Bottinger E, Brosius FC III, Coffman TM, Harris RC, Heilig CW, et al. Mouse models of diabetic nephropathy. J Am Soc Nephrol 2005; 16(1):27-45.
15. King AJ. The use of animal models in diabetes research. Br J Pharmacol 2012; 166(3):877-894.
16. Du P, Fan B, Han H, Zhen J, Shang J, Wang X, et al. NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy. Kidney Int 2013; 84(2):265-276.
17. Fornoni A, Ijaz A, Tejada T, Lenz O. Role of inflammation in diabetic nephropathy. Curr Diabetes Rev 2008; 4(1):10-17.
18. Xing Y, Ye S, Hu Y, Chen Y. Podocyte as a potential target of inflammation: role of pioglitazone hydrochloride in patients with type 2 diabetes. Endocr Pract 2012; 18(4):493-498.