Associations between age-related macular degeneration, alzheimer disease, and dementia: Record linkage study of hospital admissions

JAMA Ophthalmology

Volumn 132, Issue 1, 2014, Pages 63-68

  Keenan, Tiarnan D L ^a,c   Goldacre, Raph ^b   Goldacre, Michael J ^b   Hyman, Leslie ^d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c MANCHESTER ROYAL EYE HOSPITAL   (United Kingdom)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; DEMENTIA; DISEASE ASSOCIATION; FEMALE; HOSPITAL; HOSPITAL ADMISSION; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; UNITED KINGDOM; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; DEMENTIA; FEMALE; GREAT BRITAIN; HOSPITALIZATION; HUMANS; LIKELIHOOD FUNCTIONS; MACULAR DEGENERATION; MALE; MEDICAL RECORD LINKAGE; MIDDLE AGED; ODDS RATIO; RISK ASSESSMENT; STATE MEDICINE;

EID: 84892690361     PISSN: 21686165     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaophthalmol.2013.5696     Document Type: Article

References (29)

1. Khandhadia S, Cherry J, Lotery AJ. Age-related macular degeneration. Adv Exp Med Biol. 2012;724:15-36.
2. Ohno-Matsui K. Parallel findings in age-related macular degeneration and Alzheimer's disease. Prog Retin Eye Res. 2011;30(4):217-238.
3. Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. Age-related macular degeneration (AMD): Alzheimer's disease in the eye? J Alzheimers Dis. 2011;24(4):615-631.
4. Proitsi P, Lupton MK, Dudbridge F, Tsolaki M, et al Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. Neurobiol Aging. 2012;33(8):1843.e9-17.
5. Pham TQ, Kifley A, Mitchell P, Wang JJ. Relation of age-related macular degeneration and cognitive impairment in an older population. Gerontology. 2006;52(6):353-358. (Pubitemid 44670157)
6. Wong TY, Klein R, Nieto FJ, et al. Is early age-related maculopathy related to cognitive function? the Atherosclerosis Risk in Communities Study. Am J Ophthalmol. 2002;134(6):828-835. (Pubitemid 35425450)
7. Klaver CC, Ott A, Hofman A, Assink JJ, Breteler MM, de Jong PT. Is age-related maculopathy associated with Alzheimer's disease? the Rotterdam Study. Am J Epidemiol. 1999;150(9):963-968. (Pubitemid 29508649)
8. Woo SJ, Park KH, Ahn J, et al. Cognitive impairment in age-related macular degeneration and geographic atrophy. Ophthalmology. 2012;119(10):2094- 2101.
9. Baker ML, Wang JJ, Rogers S, et al. Early age-related macular degeneration, cognitive function, and dementia: the Cardiovascular Health Study. Arch Ophthalmol. 2009;127(5):667-673.
10. Ding JD, Johnson LV, Herrmann R, et al. Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2011;108(28):279- 287.
11. Ding JD, Lin J, Mace BE, Herrmann R, Sullivan P, Bowes Rickman C. Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model. Vision Res. 2008;48(3):339-345. (Pubitemid 351179512)
12. Jin H, Randazzo J, Zhang P, Kador PF. Multifunctional antioxidants for the treatment of age-related diseases. J Med Chem. 2010;53(3):1117-1127.
13. Cai J, Qi X, Kociok N, et al. β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. EMBO Mol Med. 2012;4(9):980-991.
14. Doyle Y, Bull A. Role of private sector inUnited Kingdom healthcare system. BMJ. 2000;321(7260):563-565.
15. Keenan TD, Salmon JF, Yeates D, Goldacre M. Trends in rates of primary angle closure glaucoma and cataract surgery in England from 1968 to 2004. J Glaucoma. 2009;18(3):201-205.
16. Health and Social Care Information Centre. Hospital episode statistics. www.hscic.gov.uk/hes. Accessed January 27, 2012.
17. Goldacre MJ, Wotton CJ, Keenan TD. Risk of selected eye diseases in people admitted to hospital for hypertension or diabetes mellitus: record linkage studies. Br J Ophthalmol. 2012;96(6):872-876.
18. Keenan TD, Wotton CJ, Goldacre MJ. Trends over time and geographical variation in rates of intravitreal injections in England. Br J Ophthalmol. 2012;96(3):413-418.
19. Fois AF, Wotton CJ, Yeates D, Turner MR, Goldacre MJ. Cancer in patients with motor neuron disease, multiple sclerosis and Parkinson's disease: record linkage studies. J Neurol Neurosurg Psychiatry. 2010;81(2):215-221.
20. Payne RA, Abel GA. UK indices ofmultiple deprevation: away to make comparisons across consituent countries easier. London, England: Office of National Statistics; 2004.www.ons.gov.uk/ons/rel/hsq/health-statistics- quarterly/no-53-spring-2012/uk-indices-of-multiple-deprivation.html. Accessed January 27, 2013.
21. Zeki Al Hazzouri A, Haan MN, Kalbfleisch JD, Galea S, Lisabeth LD, Aiello AE. Life-course socioeconomic position and incidence of dementia and cognitive impairment without dementia in older Mexican Americans: results from the Sacramento area Latino study on aging. Am J Epidemiol. 2011;173(10):1148-1158.
22. Breslow NE, Day NE. The Design and Analysis of Cohort Studies. Vol II. Lyon, France: International Agency for Research in Cancer; 1987:103-115. IARC Scientific Publication No. 82.
23. Kawasaki R, Yasuda M, Song SJ, et al. The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis. Ophthalmology. 2010;117(5):921-927.
24. Kim SJ, Lee SJ, Kim NR, Chin HS. Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population. Exp Eye Res. 2012;96(1):42-47.
25. Curtis LH, Hammill BG, Qualls LG, et al. Treatment patterns for neovascular age-related macular degeneration: analysis of 284 380 Medicare beneficiaries. Am J Ophthalmol. 2012;153(6):1116-1124, e1.
26. Shah R, Evans BJ, Edgar D. A survey of the availability of state-funded primary eye care in the UK for the very young and very old. Ophthalmic Physiol Opt. 2007;27(5):473-481. (Pubitemid 47283822)
27. Thorpe CT, Thorpe JM, Kind AJ, Bartels CM, Everett CM, Smith MA. Receipt of monitoring of diabetes mellitus in older adults with comorbid dementia. J AmGeriatr Soc. 2012;60(4):644-651.
28. Koch JM, Datta G, Makhdoom S, Grossberg GT. Unmet visual needs of Alzheimer's disease patients in long-term care facilities. J AmMed Dir Assoc. 2005;6(4):233-237.
29. The Dementia and Sight Loss Interest Group (DaSLIG). Homepage. www.macularsociety.org/. Accessed January 27, 2012.