Conjugation with receptor-targeted histidine-rich peptides enhances the pharmacological effectiveness of antisense oligonucleotides

Bioconjugate Chemistry

Volumn 25, Issue 1, 2014, Pages 165-170

  Nakagawa, Osamu ^a   Ming, Xin ^a   Carver, Kyle ^a   Juliano, Rudy ^a  

^a University of North Carolina   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; DISEASES; MOLECULES; OLIGONUCLEOTIDES;

ANTISENSE; ANTISENSE OLIGONUCLEOTIDES; CELL SURFACE RECEPTORS; ENDOSOMAL DISRUPTION; HISTIDINE RESIDUES; MOLECULAR SCALE; OLIGONUCLEOTIDE CONJUGATES; PROSTATE CANCER CELLS; RECEPTOR TARGETING; THERAPEUTIC AGENTS;

PEPTIDES;

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; BOMBESIN; BOMBESIN RECEPTOR; CELL SURFACE RECEPTOR; HISTIDINE; LUCIFERASE; MONOVALENT BOMBESIN HISTIDINE 6 CONJUGATED 623 OLICONUCLEOTIDE; TRIVALENT BOMBESIN CONJUGATED 623 OLIGONUCLEOTIDE; UNCLASSIFIED DRUG; HISTIDINE-RICH PROTEINS; PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CANCER CELL CULTURE; CELL DISRUPTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG RECEPTOR BINDING; ENDOSOME; INTRON; PROSTATE CANCER; PROTEIN EXPRESSION; TARGET CELL; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; OLIGONUCLEOTIDES, ANTISENSE; PROTEINS; RECEPTORS, BOMBESIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84892688381     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc400500h     Document Type: Article

References (29)

1. Bennett, C. F. and Swayze, E. E. (2010) RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform Annu. Rev. Pharmacol. Toxicol. 50, 259-93
2. Burnett, J. C. and Rossi, J. J. (2012) RNA-based therapeutics: current progress and future prospects Chem. Biol. 19, 60-71
3. Krutzfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., and Stoffel, M. (2005) Silencing of microRNAs in vivo with 'antagomirs' Nature 438, 685-9
4. Kole, R., Krainer, A. R., and Altman, S. (2012) RNA therapeutics: beyond RNA interference and antisense oligonucleotides Nat. Rev. Drug Discovery 11, 125-40
5. Soldati, C., Bithell, A., Conforti, P., Cattaneo, E., and Buckley, N. J. (2011) Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease J. Neurochem. 116, 415-25
6. Vollmer, J. and Krieg, A. M. (2009) Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists Adv. Drug Delivery Rev. 61, 195-204
7. Chin, J. Y. and Glazer, P. M. (2009) Repair of DNA lesions associated with triplex-forming oligonucleotides Mol. Carcinog. 48, 389-99
8. Vaishnaw, A. K., Gollob, J., Gamba-Vitalo, C., Hutabarat, R., Sah, D., Meyers, R., de Fougerolles, T., and Maraganore, J. (2010) A status report on RNAi therapeutics Silence 1, 14
9. Watts, J. K. and Corey, D. R. (2012) Silencing disease genes in the laboratory and the clinic J. Pathol. 226, 365-79
10. Juliano, R., Bauman, J., Kang, H., and Ming, X. (2009) Biological barriers to therapy with antisense and siRNA oligonucleotides Mol. Pharm. 6, 686-95
11. Whitehead, K. A., Langer, R., and Anderson, D. G. (2009) Knocking down barriers: advances in siRNA delivery Nat. Rev. Drug Discovery 8, 129-38
12. Schroeder, A., Levins, C. G., Cortez, C., Langer, R., and Anderson, D. G. (2010) Lipid-based nanotherapeutics for siRNA delivery J. Intern. Med. 267, 9-21
13. Aliabadi, H. M., Landry, B., Sun, C., Tang, T., and Uludag, H. (2012) Supramolecular assemblies in functional siRNA delivery: where do we stand? Biomaterials 33, 2546-69
14. Tamura, A. and Nagasaki, Y. (2010) Smart siRNA delivery systems based on polymeric nanoassemblies and nanoparticles Nanomedicine (London) 5, 1089-102
15. Hobel, S. and Aigner, A. (2013) Polyethylenimines for siRNA and miRNA delivery in vivo Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 5, 484-501
16. Andaloussi, S. E., Lehto, T., Mager, I., Rosenthal-Aizman, K., Oprea, I. I., Simonson, O. E., Sork, H., Ezzat, K., Copolovici, D. M., Kurrikoff, K., Viola, J. R., Zaghloul, E. M., Sillard, R., Johansson, H. J., Said Hassane, F., Guterstam, P., Suhorutsenko, J., Moreno, P. M., Oskolkov, N., Halldin, J., Tedebark, U., Metspalu, A., Lebleu, B., Lehtio, J., Smith, C. I., and Langel, U. (2011) Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo Nucleic Acids Res. 39, 3972-87
17. Presente, A. and Dowdy, S. F. (2013) PTD/CPP peptide-mediated delivery of siRNAs Curr. Pharm. Des. 19, 2943-7
18. Dassie, J. P., Liu, X. Y., Thomas, G. S., Whitaker, R. M., Thiel, K. W., Stockdale, K. R., Meyerholz, D. K., McCaffrey, A. P., McNamara, J. O., 2nd, and Giangrande, P. H. (2009) Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors Nat. Biotechnol. 27, 839-49
19. Kortylewski, M., Swiderski, P., Herrmann, A., Wang, L., Kowolik, C., Kujawski, M., Lee, H., Scuto, A., Liu, Y., Yang, C., Deng, J., Soifer, H. S., Raubitschek, A., Forman, S., Rossi, J. J., Pardoll, D. M., Jove, R., and Yu, H. (2009) In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses Nat. Biotechnol. 27, 925-32
20. Alam, M. R., Dixit, V., Kang, H., Li, Z. B., Chen, X., Trejo, J., Fisher, M., and Juliano, R. L. (2008) Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis Nucleic Acids Res. 36, 2764-76
21. Alam, M. R., Ming, X., Fisher, M., Lackey, J. G., Rajeev, K. G., Manoharan, M., and Juliano, R. L. (2011) Multivalent cyclic RGD conjugates for targeted delivery of small interfering RNA Bioconjugate Chem. 22, 1673-81
22. Ming, X., Alam, M. R., Fisher, M., Yan, Y., Chen, X., and Juliano, R. L. (2010) Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor Nucleic Acids Res. 38, 6567-76
23. Sethi, D., Chen, C. P., Jing, R. Y., Thakur, M. L., and Wickstrom, E. (2012) Fluorescent peptide-PNA chimeras for imaging monoamine oxidase A mRNA in neuronal cells Bioconjugate Chem. 23, 158-63
24. Akinc, A., Querbes, W., De, S., Qin, J., Frank-Kamenetsky, M., Jayaprakash, K. N., Jayaraman, M., Rajeev, K. G., Cantley, W. L., Dorkin, J. R., Butler, J. S., Qin, L., Racie, T., Sprague, A., Fava, E., Zeigerer, A., Hope, M. J., Zerial, M., Sah, D. W., Fitzgerald, K., Tracy, M. A., Manoharan, M., Koteliansky, V., Fougerolles, A., and Maier, M. A. (2010) Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms Mol. Ther. 18, 1357-64
25. Tseng, Y. C., Mozumdar, S., and Huang, L. (2009) Lipid-based systemic delivery of siRNA Adv. Drug Delivery Rev. 61, 721-31
26. Midoux, P., Pichon, C., Yaouanc, J. J., and Jaffres, P. A. (2009) Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers Br. J. Pharmacol. 157, 166-78
27. Prongidi-Fix, L., Sugawara, M., Bertani, P., Raya, J., Leborgne, C., Kichler, A., and Bechinger, B. (2007) Self-promoted cellular uptake of peptide/DNA transfection complexes Biochemistry 46, 11253-62
28. Juliano, R. L., Ming, X., and Nakagawa, O. (2011) Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides Bioconjugate Chem. 23, 147-57
29. Dunn, K. W., Kamocka, M. M., and McDonald, J. H. (2011) A practical guide to evaluating colocalization in confocal microscopy Am. J. Physiol. Cell Physiol. 300, C723-742