Systemic and neuronal inflammatory markers in a mouse model of mevalonate kinase deficiency: A strain-comparative study

In Vivo

Volumn 27, Issue 6, 2013, Pages 715-722

  Kleiner, Giulio ^a   Celsi, Fulvio ^a   Tricarico, Paola Maura ^b   Zacchigna, Serena ^c   Crovella, Sergio ^a,b   Marcuzzi, Annalisa ^a  

^a INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

Alendronate; BALB c; C57BL 6; Inflammasome; Mevalonate kinase deficiency; Muramyl dipeptide

Indexed keywords

ALENDRONIC ACID; BIOLOGICAL MARKER; CHEMOKINE; CRYOPYRIN; CYTOKINE; INFLAMMASOME; MEVALONATE KINASE; MURAMYL DIPEPTIDE; SERUM AMYLOID A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; C57BL 6 MOUSE; CELL INFILTRATION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE; MALE; MEVALONATE KINASE DEFICIENCY; MOUSE; MOUSE MODEL; MOUSE STRAIN; NONHUMAN; RELIABILITY; SPLEEN;

ALENDRONATE; BALB/C; C57BL/6; INFLAMMASOME; MEVALONATE KINASE DEFICIENCY; MURAMYL DIPEPTIDE;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ALENDRONATE; ANIMALS; BIOLOGICAL MARKERS; CARRIER PROTEINS; CYTOKINES; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMASOMES; INFLAMMATION MEDIATORS; MALE; MEVALONATE KINASE DEFICIENCY; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SPLEEN;

EID: 84892684145     PISSN: 0258851X     EISSN: 17917549     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Hoffmann G, Gibson KM, Brandt IK, Bader PI, Wappner RS and Sweetman L: Mevalonic aciduria - an inborn error of cholesterol and nonsterol isoprene biosynthesis. N Engl J Med 314: 1610-1614, 1986.
2. Haas D and Hoffmann GF: Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. Orphanet J Rare Dis 1: 13, 2006.
3. Neven B, Valayannopoulos V, Quartier P, Blanche S, Prieur AM, Debre M, Rolland MO, Rabier D, Cuisset L, Cavazzana-Calvo M, de Lonlay P and Fischer A: Allogeneic bone marrow transplantation in mevalonic aciduria. N Engl J Med 356: 2700- 2703, 2007.
4. Mandey SH, Kuijk LM, Frenkel J and Waterham HR: A role for geranylgeranylation in interleukin-1beta secretion. Arthritis Rheum 54: 3690-3695, 2006.
5. Normand S, Massonnet B, Delwail A, Favot L, Cuisset L, Grateau G, Morel F, Silvain C and Lecron JC: Specific increase in caspase-1 activity and secretion of IL-1 family cytokines: a putative link between mevalonate kinase deficiency and inflammation. Eur Cytokine Net 20: 101-107, 2009.
6. Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ and Golenbock DT: The NALP3 inflammasome is involved in the innate immune response to amyloid-β. Nat Immunol 9: 857-865, 2008.
7. Pontillo A, Paoluzzi E and Crovella S: The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency. Eur J Hum Genet 18: 844-847, 2010.
8. Shi F, Yang L, Kouadir M, Yang Y, Wang J, Zhou X, Yin X and Zhao D: The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation. J Neuroinflamm 9: 73, 2012.
9. Zou J and Crews FT: Inflammasome-IL-1beta Signaling Mediates Ethanol Inhibition of Hippocampal Neurogenesis. Front Neurosci 6: 77, 2012.
10. Marcuzzi A, Pontillo A, De Leo L, Tommasini A, Decorti G, Not T and Ventura A: Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency. Pediatr Res 64: 177-182, 2008.
11. Kuijk LM, Mandey SH, Schellens I, Waterham HR, Rijkers GT, Coffer PJ and Frenkel J: Statin synergizes with LPS to induce IL-1beta release by THP-1 cells through activation of caspase-1. Mol Immunol 45: 2158-2165, 2008.
12. Marcuzzi A, Piscianz E, Girardelli M, Crovella S and Pontillo A: Defect in mevalonate pathway induces pyroptosis in Raw 264.7 murine monocytes. Apoptosis 16: 882-888, 2011.
13. Golde WT, Gollobin P and Rodriguez LL: A rapid, simple, and humane method for submandibular bleeding of mice using a lancet. Lab Animal 34: 39-43, 2005.
14. Hager EJ, Tse HM, Piganelli JD, Gupta M, Baetscher M, Tse TE, Pappu AS, Steiner RD, Hoffmann GF and Gibson KM: Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome. J Inherit Metab Dis 30: 888-895, 2007.
15. Lira SA and Furtado GC: The biology of chemokines and their receptors. Immunol Res 54: 111-120, 2012.
16. Marcuzzi A, Tommasini A, Crovella S and Pontillo A: Natural isoprenoids inhibit LPS-induced-production of cytokines and nitric oxide in aminobisphosphonate-treated monocytes. Int Immunopharmacol 10: 639-642, 2010.
17. Drenth JP, van Deuren M, van der Ven-Jongekrijg J, Schalkwijk CG and van der Meer JW: Cytokine activation during attacks of the hyperimmunoglobulinemia D and periodic fever syndrome. Blood 85: 3586-3593, 1995.
18. Cailliez M, Garaix F, Rousset-Rouviere C, Bruno D, Kone-Paut I, Sarles J, Chabrol B and Tsimaratos M: Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis. J Inherit Metab Dis 29: 763, 2006.
19. Galeotti C, Meinzer U, Quartier P, Rossi-Semerano L, Bader-Meunier B, Pillet P and Kone-Paut I: Efficacy of interleukin-1- targeting drugs in mevalonate kinase deficiency. Rheumatology (Oxford) 51: 1855-1859, 2012.
20. Yin Y, Yan Y, Jiang X, Mai J, Chen NC, Wang H and Yang XF: Inflammasomes are differentially expressed in cardiovascular and other tissues. Int J Immunopathol Pharmacol 22: 311-322, 2009.
21. Ransohoff RM and Perry VH: Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol 27: 119-145, 2009.
22. Omari KM, Lutz SE, Santambrogio L, Lira SA and Raine CS: Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1. Am J Pathol 174: 164-176, 2009.
23. Pitzer C, Kruger C, Plaas C, Kirsch F, Dittgen T, Muller R, Laage R, Kastner S, Suess S, Spoelgen R, Henriques A, Ehrenreich H, Schabitz WR, Bach A and Schneider A: Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis. Brain 131: 3335- 3347, 2008.
24. Schneider A, Kruger C, Steigleder T, Weber D, Pitzer C, Laage R, Aronowski J, Maurer MH, Gassler N, Mier W, Hasselblatt M, Kollmar R, Schwab S, Sommer C, Bach A, Kuhn HG and Schabitz WR: The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Inves 115: 2083-2098, 2005.
25. Marcuzzi A, Zanin V, Kleiner G, Monasta L and Crovella S: Mouse model of mevalonate kinase deficiency: comparison of cytokine and chemokine profile with that of human patients. Pediatr Res 74: 266-271, 2013.