메뉴 건너뛰기




Volumn 123, Issue 4, 2013, Pages 356-370

Fibrates reduce triacylglycerol content by upregulating adipose triglyceride lipase in the liver of rats

Author keywords

Adipose triglyceride lipase; Fibrate; Fibric acid; Rat liver; Triacylglycerol

Indexed keywords

BEZAFIBRATE; CLOFIBRIC ACID; FENOFIBRATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

EID: 84892654182     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.13149FP     Document Type: Article
Times cited : (18)

References (49)
  • 1
    • 0035998737 scopus 로고    scopus 로고
    • Physiological and therapeutic roles of peroxisome proliferator-activated receptors
    • Berger J, Wagner JA. Physiological and therapeutic roles of peroxisome proliferator-activated receptors. Diabetes Technol. Ther. 2002;4:163-174.
    • (2002) Diabetes Technol. Ther. , vol.4 , pp. 163-174
    • Berger, J.1    Wagner, J.A.2
  • 2
    • 36949009469 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptors and lipoprotein metabolism
    • Kersten S. Peroxisome proliferator activated receptors and lipoprotein metabolism. PPAR Res. 2008;2008:132960.
    • (2008) PPAR Res , vol.2008 , pp. 132960
    • Kersten, S.1
  • 3
    • 37549041988 scopus 로고    scopus 로고
    • Is there a role for fibrates in the management of dyslipidemia in the metabolic syndrome?
    • Barter PJ, Rye K-A. Is there a role for fibrates in the management of dyslipidemia in the metabolic syndrome? Arterioscler Thromb Vasc Biol. 2008;28:39-46.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 39-46
    • Barter, P.J.1    Rye, K.-A.2
  • 4
    • 77952708442 scopus 로고    scopus 로고
    • Effects of fibrates on cardiovascular outcomes: A systematic review and meta-analysis
    • Jun M, Foote C, Lv J, Neal B, Patel A, Nicholls SJ, et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet. 2010;375:1875-1884.
    • (2010) Lancet , vol.375 , pp. 1875-1884
    • Jun, M.1    Foote, C.2    Lv, J.3    Neal, B.4    Patel, A.5    Nicholls, S.J.6
  • 5
    • 84867139643 scopus 로고    scopus 로고
    • PPAR agonists for the treatment of cardiovascular disease in patients with diabetes
    • Wilding JPH. PPAR agonists for the treatment of cardiovascular disease in patients with diabetes. Diabetes Obese Metab. 2012;14:973-982.
    • (2012) Diabetes Obese Metab , vol.14 , pp. 973-982
    • Wilding, J.P.H.1
  • 6
    • 0034595980 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α activators improve insulin sensitivity and reduce adiposity
    • Guerre-Millo M, Gervois P, Raspé E, Madsen L, Poulain P, Derudas B, et al. Peroxisome proliferator-activated receptor α activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000;275:16638-16642.
    • (2000) J Biol Chem , vol.275 , pp. 16638-16642
    • Guerre-Millo, M.1    Gervois, P.2    Raspé, E.3    Madsen, L.4    Poulain, P.5    Derudas, B.6
  • 7
    • 84857984149 scopus 로고    scopus 로고
    • Dislipidemia in patients with nonalcoholic fatty liver disease
    • Chatrath H, Vuppalanchi R, Chalasani N. Dislipidemia in patients with nonalcoholic fatty liver disease. Semin Liver Dis. 2012;32:22-29.
    • (2012) Semin Liver Dis , vol.32 , pp. 22-29
    • Chatrath, H.1    Vuppalanchi, R.2    Chalasani, N.3
  • 8
    • 84864290671 scopus 로고    scopus 로고
    • Lipid-lowering agents in non-alcoholic fatty liver disease and steatohepatitis: Human studies
    • Nseir W, Mograbi J, Ghali M. Lipid-lowering agents in non-alcoholic fatty liver disease and steatohepatitis: Human studies. Dig Dis Sci. 2012;57:1773-1781.
    • (2012) Dig Dis Sci , vol.57 , pp. 1773-1781
    • Nseir, W.1    Mograbi, J.2    Ghali, M.3
  • 10
    • 67349165558 scopus 로고    scopus 로고
    • Fate of fat: The role of adipose triglyceride lipase in lipolysis
    • Zimmermann R, Lass A, Haemmerle G, Zechner R. Fate of fat: the role of adipose triglyceride lipase in lipolysis. Biochim Biophys Acta. 2009;1791:494-500.
    • (2009) Biochim Biophys Acta , vol.1791 , pp. 494-500
    • Zimmermann, R.1    Lass, A.2    Haemmerle, G.3    Zechner, R.4
  • 11
    • 78751496304 scopus 로고    scopus 로고
    • Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning
    • Ong KT, Mashek MT, Bu SY, Greenberg AS, Mashek DG. Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning. Hepatology. 2011;53:116-126.
    • (2011) Hepatology , vol.53 , pp. 116-126
    • Ong, K.T.1    Mashek, M.T.2    Bu, S.Y.3    Greenberg, A.S.4    Mashek, D.G.5
  • 12
    • 79959550724 scopus 로고    scopus 로고
    • Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis
    • Wu JW, Wang SP, Alvarez F, Casavant S, Gauthier N, Abed L, et al. Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis. Hepatology. 2011;54:122-132.
    • (2011) Hepatology , vol.54 , pp. 122-132
    • Wu, J.W.1    Wang, S.P.2    Alvarez, F.3    Casavant, S.4    Gauthier, N.5    Abed, L.6
  • 13
    • 79953787445 scopus 로고    scopus 로고
    • Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice
    • Turpin SM, Hoy AJ, Brown RD, Rudaz CG, Honeyman J, Matzaris M, et al. Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia. 2011;54:146-156.
    • (2011) Diabetologia , vol.54 , pp. 146-156
    • Turpin, S.M.1    Hoy, A.J.2    Brown, R.D.3    Rudaz, C.G.4    Honeyman, J.5    Matzaris, M.6
  • 14
    • 45149123679 scopus 로고    scopus 로고
    • Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis
    • Reid NB, Ables GP, Otlivanchik OA, Schoiswohl G, Zechner R, Blaner WS, et al. Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis. J Biol Chem. 2008;283:13087-13099.
    • (2008) J Biol Chem , vol.283 , pp. 13087-13099
    • Reid, N.B.1    Ables, G.P.2    Otlivanchik, O.A.3    Schoiswohl, G.4    Zechner, R.5    Blaner, W.S.6
  • 15
    • 33645076793 scopus 로고    scopus 로고
    • Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism
    • Fruchart JC, Duriez P. Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism. Drugs Today. 2006;42:39-64.
    • (2006) Drugs Today , vol.42 , pp. 39-64
    • Fruchart, J.C.1    Duriez, P.2
  • 16
    • 79955586140 scopus 로고    scopus 로고
    • Dual acting and pan-PPAR activators as potential anti-diabetic therapies
    • Schwanstecher M, editor. Diabets - perspectives in drug therapy. Heidelberg: Springer
    • Heald M, Cawthorne MA. Dual acting and pan-PPAR activators as potential anti-diabetic therapies. In: Schwanstecher M, editor. Diabets - perspectives in drug therapy. Handbook of Experimental Pharmacology. Heidelberg: Springer; 2011;203:35-51.
    • (2011) Handbook of Experimental Pharmacology , vol.203 , pp. 35-51
    • Heald, M.1    Cawthorne, M.A.2
  • 18
    • 0032779170 scopus 로고    scopus 로고
    • Increase in hepatic content of oleic acid induced by dehydroepiandrosterone in the rat
    • Imai K, Koyama M, Kudo N, Shirahata A, Kawashima Y. Increase in hepatic content of oleic acid induced by dehydroepiandrosterone in the rat. Biochem Pharmacol. 1999;58:925-933.
    • (1999) Biochem Pharmacol , vol.58 , pp. 925-933
    • Imai, K.1    Koyama, M.2    Kudo, N.3    Shirahata, A.4    Kawashima, Y.5
  • 19
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911-917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 20
  • 21
    • 84880570761 scopus 로고    scopus 로고
    • Up-regulation of stearoyl-CoA desaturase 1 increases liver MUFA content in obese Zucker but not Goto-Kakizaki rats
    • Karahashi M, Ishii F, Yamazaki T, Imai K, Mitsumoto A, Kawashima Y, et al. Up-regulation of stearoyl-CoA desaturase 1 increases liver MUFA content in obese Zucker but not Goto-Kakizaki rats. Lipids. 2013;48:457-467.
    • (2013) Lipids , vol.48 , pp. 457-467
    • Karahashi, M.1    Ishii, F.2    Yamazaki, T.3    Imai, K.4    Mitsumoto, A.5    Kawashima, Y.6
  • 23
    • 0032608438 scopus 로고    scopus 로고
    • Hormone-sensitive lipase and neutral cholestery ester lipase
    • Holm C, Østerlund T. Hormone-sensitive lipase and neutral cholestery ester lipase. Methods Mol Biol. 1999;109:109-121.
    • (1999) Methods Mol Biol , vol.109 , pp. 109-121
    • Holm, C.1    Østerlund, T.2
  • 24
    • 84864116265 scopus 로고    scopus 로고
    • Fenofibrate lowers lipid accumulation in myotubes by modulating the PPARα/AMPK/FoxO1/ATGL pathway
    • Chen W-L, Chen Y-L, Chiang Y-M, Wang S-G, Lee H-M. Fenofibrate lowers lipid accumulation in myotubes by modulating the PPARα/AMPK/FoxO1/ATGL pathway. Biochem Pharmacol. 2012;84:522-531.
    • (2012) Biochem Pharmacol , vol.84 , pp. 522-531
    • Chen, W.-L.1    Chen, Y.-L.2    Chiang, Y.-M.3    Wang, S.-G.4    Lee, H.-M.5
  • 26
    • 2142810109 scopus 로고    scopus 로고
    • Profiling of hepatic gene expression in rats treated with fibric acid analogs
    • Cornwell PD, De Souza AT, Ulrich RG. Profiling of hepatic gene expression in rats treated with fibric acid analogs. Muat Res. 2004;549:131-145.
    • (2004) Muat Res , vol.549 , pp. 131-145
    • Cornwell, P.D.1    De Souza, A.T.2    Ulrich, R.G.3
  • 27
    • 66949149506 scopus 로고    scopus 로고
    • Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids
    • Akkaoui M, Cohen I, Esnous C, Lenoir V, Sournac M, Girard J, et al. Modulation of the hepatic malonyl-CoA-carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids. Biochem J. 2009;420:429-438.
    • (2009) Biochem J , vol.420 , pp. 429-438
    • Akkaoui, M.1    Cohen, I.2    Esnous, C.3    Lenoir, V.4    Sournac, M.5    Girard, J.6
  • 28
    • 0018356140 scopus 로고
    • Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats
    • Mannaerts GP, Debeer LJ, Thomas J, De Schepper PJ. Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats. J Biol Chem. 1979;254:4585-4595.
    • (1979) J Biol Chem , vol.254 , pp. 4585-4595
    • Mannaerts, G.P.1    Debeer, L.J.2    Thomas, J.3    De Schepper, P.J.4
  • 29
    • 0031043030 scopus 로고    scopus 로고
    • The Mitochondrial carnitine palmitoyltransferase system - From concept to molecular analysis
    • McGarry JD, Brown NF. The Mitochondrial carnitine palmitoyltransferase system - from concept to molecular analysis. Eur J Biochem. 1997;244:1-14.
    • (1997) Eur J Biochem , vol.244 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 31
    • 0031711606 scopus 로고    scopus 로고
    • Use of cytosolic triacylglycerol hydrolysis products and of exogenous fatty acid for the synthesis of triacylglycerol secreted by cultured rat hepatocytes
    • Lankester DL, Brown AM, Zammit VA. Use of cytosolic triacylglycerol hydrolysis products and of exogenous fatty acid for the synthesis of triacylglycerol secreted by cultured rat hepatocytes. J Lipid Res. 1998;39:1889-1895.
    • (1998) J Lipid Res , vol.39 , pp. 1889-1895
    • Lankester, D.L.1    Brown, A.M.2    Zammit, V.A.3
  • 32
    • 74949084316 scopus 로고    scopus 로고
    • Membrane fatty acid transporters as regulators of lipid metabolism: Implications for metabolic disease
    • Glatz JFC, Luiken JJFP, Bonen A. Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease. Physiol Rev. 2010;90:367-417.
    • (2010) Physiol Rev , vol.90 , pp. 367-417
    • Glatz, J.F.C.1    Luiken, J.J.F.P.2    Bonen, A.3
  • 33
    • 84860311914 scopus 로고    scopus 로고
    • The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake
    • Poppelreuther M, Rudolph B, Du C, Großmann R, Becker M, Thiele C, et al. The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake. J Lipid Res. 2012;53:888-900.
    • (2012) J Lipid Res , vol.53 , pp. 888-900
    • Poppelreuther, M.1    Rudolph, B.2    Du, C.3    Großmann, R.4    Becker, M.5    Thiele, C.6
  • 34
    • 84855679348 scopus 로고    scopus 로고
    • Differential induction of stearoyl-CoA desaturase 1 and 2 genes by fibrates in the liver of rats
    • Yamazaki T, Okada H, Sakamoto T, Sunaga K, Tsuda T, Mitsumoto A, et al. Differential induction of stearoyl-CoA desaturase 1 and 2 genes by fibrates in the liver of rats. Biol Pharm Bull. 2012;35:116-120.
    • (2012) Biol Pharm Bull , vol.35 , pp. 116-120
    • Yamazaki, T.1    Okada, H.2    Sakamoto, T.3    Sunaga, K.4    Tsuda, T.5    Mitsumoto, A.6
  • 35
    • 0021983439 scopus 로고
    • Regulation of palmitoyl-CoA chain elongation and linoleoyl-CoA elongation in rat liver microsomes and the differential effects of peroxisome proliferators, insulin and thyroid hormone
    • Kawashima Y, Kozuka H. Regulation of palmitoyl-CoA chain elongation and linoleoyl-CoA elongation in rat liver microsomes and the differential effects of peroxisome proliferators, insulin and thyroid hormone. Biochim Biophys Acta. 1985;834:118-123.
    • (1985) Biochim Biophys Acta , vol.834 , pp. 118-123
    • Kawashima, Y.1    Kozuka, H.2
  • 36
    • 0020355515 scopus 로고
    • Increased activity of stearoyl-CoA desaturation in liver from rat fed clofibric acid
    • Kawashima Y, Kozuka H. Increased activity of stearoyl-CoA desaturation in liver from rat fed clofibric acid. Biochim Biophys Acta. 1982;713:622-628.
    • (1982) Biochim Biophys Acta , vol.713 , pp. 622-628
    • Kawashima, Y.1    Kozuka, H.2
  • 37
    • 84860392273 scopus 로고    scopus 로고
    • Clofibric acid increases the formation of oleic acid in endoplasmic reticulum of the liver of rats
    • Hirose A, Yamazaki T, Sakamoto T, Sunaga K, Tsuda T, Mitsumoto A, et al. Clofibric acid increases the formation of oleic acid in endoplasmic reticulum of the liver of rats. J Pharmacol Sci. 2011;116:362-372.
    • (2011) J Pharmacol Sci , vol.116 , pp. 362-372
    • Hirose, A.1    Yamazaki, T.2    Sakamoto, T.3    Sunaga, K.4    Tsuda, T.5    Mitsumoto, A.6
  • 38
    • 33748757743 scopus 로고    scopus 로고
    • Colocalization of SCD1 and DGAT2: Implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis
    • Man WC, Miyazaki M, Chu K, Ntambi J. Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. J Lipid Res. 2006;47:1928-1939.
    • (2006) J Lipid Res , vol.47 , pp. 1928-1939
    • Man, W.C.1    Miyazaki, M.2    Chu, K.3    Ntambi, J.4
  • 39
    • 0034958783 scopus 로고    scopus 로고
    • A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
    • Miyazak M, Kim Y-C, Ntambi JM. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J Lipid Res. 2001;42:1018-1024.
    • (2001) J Lipid Res , vol.42 , pp. 1018-1024
    • Miyazak, M.1    Kim, Y.-C.2    Ntambi, J.M.3
  • 41
    • 36248982581 scopus 로고    scopus 로고
    • Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling
    • Rakhshandehroo M, Sanderson LM, Matilainen M, Stienstra R, Carlberg C, de Groot PJ, et al. Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR Res. 2007;2007:26839.
    • (2007) PPAR Res , vol.2007 , pp. 26839
    • Rakhshandehroo, M.1    Sanderson, L.M.2    Matilainen, M.3    Stienstra, R.4    Carlberg, C.5    De Groot, P.J.6
  • 42
    • 0036479293 scopus 로고    scopus 로고
    • The peroxisome proliferator-induced cytosolic type I acyl-CoA thioesterase (CTE-I) is a serine-histidine-aspartic acid α/β hydrolase
    • Huhtinen K, O'Byrne J, Lindquist PJG, Contreras JA, Alexson SEH. The peroxisome proliferator-induced cytosolic type I acyl-CoA thioesterase (CTE-I) is a serine-histidine-aspartic acid α/β hydrolase. J Biol Chem. 2002;277:3424-3432.
    • (2002) J Biol Chem , vol.277 , pp. 3424-3432
    • Huhtinen, K.1    O'Byrne, J.2    Lindquist, P.J.G.3    Contreras, J.A.4    Alexson, S.E.H.5
  • 43
    • 34548164420 scopus 로고    scopus 로고
    • The acyl-CoA thioesterase I is regulated by PPARα and HNF4α via a distal response element in the promoter
    • Dongol B, Shah Y, Kim I, Gonzalez FJ, Hunt MC. The acyl-CoA thioesterase I is regulated by PPARα and HNF4α via a distal response element in the promoter. J Lipid Res. 2007;48:1781-1791.
    • (2007) J Lipid Res , vol.48 , pp. 1781-1791
    • Dongol, B.1    Shah, Y.2    Kim, I.3    Gonzalez, F.J.4    Hunt, M.C.5
  • 44
    • 49049137826 scopus 로고
    • Sex-related difference in the effect of clofibric acid on induction of two novel long-chain acyl-CoA hydrolases in rat liver
    • Kawashima Y, Katoh H, Kozuka H. Sex-related difference in the effect of clofibric acid on induction of two novel long-chain acyl-CoA hydrolases in rat liver. Biochim Biophys Acta. 1982;712:48-56.
    • (1982) Biochim Biophys Acta , vol.712 , pp. 48-56
    • Kawashima, Y.1    Katoh, H.2    Kozuka, H.3
  • 45
    • 69449087522 scopus 로고    scopus 로고
    • Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor α activity
    • Sapiro JM, Mashek MT, Greenberg AS, Mashek DG. Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor α activity. J Lipid Res. 2009;50:1621-1629.
    • (2009) J Lipid Res , vol.50 , pp. 1621-1629
    • Sapiro, J.M.1    Mashek, M.T.2    Greenberg, A.S.3    Mashek, D.G.4
  • 46
    • 44449118921 scopus 로고    scopus 로고
    • Fatty acid-binding proteins: Role in metabolic diseases and potential as drug targets
    • Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov. 2008;7:489-503.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 489-503
    • Furuhashi, M.1    Hotamisligil, G.S.2
  • 47
    • 0027955468 scopus 로고
    • Regulation of hepatic level of fatty-acid-binding protein by hormones and clofibric acid in the rat
    • Nakagawa S, Kawashima Y, Hirose A, Kozuka H. Regulation of hepatic level of fatty-acid-binding protein by hormones and clofibric acid in the rat. Biochem J. 1994;297:581-584.
    • (1994) Biochem J , vol.297 , pp. 581-584
    • Nakagawa, S.1    Kawashima, Y.2    Hirose, A.3    Kozuka, H.4
  • 48
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
    • Forman BM, Chen J, Evans RM. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc Natl Acad Sci U S A. 1997;94:4312-4317.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 49
    • 0006132932 scopus 로고    scopus 로고
    • Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
    • Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc Natl Acad Sci U S A. 1997;94:4318-4323.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4318-4323
    • Kliewer, S.A.1    Sundseth, S.S.2    Jones, S.A.3    Brown, P.J.4    Wisely, G.B.5    Koble, C.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.