-
1
-
-
85195007676
-
-
Chemical Safety Office, Chemical Management Policy Division, Manufacturing Industries Bureau, Ministry of Economy, Trade and Industry (METI). Chemical Substances Control Law, METI, Tokyo, 2011. Available at
-
Chemical Safety Office, Chemical Management Policy Division, Manufacturing Industries Bureau, Ministry of Economy, Trade and Industry (METI). Chemical Substances Control Law, METI, Tokyo, 2011. Available at http://www.meti.go.jp/policy/chemical_management/english/cscl/files/about/about_points.pdf.
-
-
-
-
2
-
-
85194991065
-
-
European Parliament and Council of the European Union, Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC, Annex VIII, Off. J. Eur. Union L396 (2006), pp. 330-343
-
European Parliament and Council of the European Union, Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC, Annex VIII, Off. J. Eur. Union L396 (2006), pp. 330-343.
-
-
-
-
3
-
-
85194978830
-
Adverse outcome pathways: a way of linking chemical structure to in vivo toxicological hazards
-
In: Cronin M., Madden J., editors Cambridge,: Royal Society of Chemistry
-
Schultz, T.W. 2010. " Adverse outcome pathways: a way of linking chemical structure to in vivo toxicological hazards ". In In Silico Toxicology, Edited by: Cronin, M. and Madden, J. 67 - 88. Cambridge: Royal Society of Chemistry.
-
(2010)
In Silico Toxicology
, pp. 67-88
-
-
Schultz, T.W.1
-
4
-
-
85194998497
-
-
Organisation for Economic Co-operation and Development (OECD), OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 138. Report of the Workshop on Using Mechanistic Information in Forming Chemical Categories, OECD, Paris, 2011
-
Organisation for Economic Co-operation and Development (OECD), OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 138. Report of the Workshop on Using Mechanistic Information in Forming Chemical Categories, OECD, Paris, 2011.
-
-
-
-
5
-
-
57349146797
-
Category analysis of the substituted anilines studied in a 28-day repeat-dose toxicity test conducted on rats: Correlation between toxicity and chemical structure
-
Sakuratani, Y., Sato, S., Nishikawa, S., Yamada, J., Maekawa, A. and Hayashi, M. 2008. Category analysis of the substituted anilines studied in a 28-day repeat-dose toxicity test conducted on rats: Correlation between toxicity and chemical structure. SAR QSAR Environ. Res., 19: 681 - 696.
-
(2008)
SAR QSAR Environ. Res.
, vol.19
, pp. 681-696
-
-
Sakuratani, Y.1
Sato, S.2
Nishikawa, S.3
Yamada, J.4
Maekawa, A.5
Hayashi, M.6
-
6
-
-
85195007749
-
-
No. 138, Report of the Workshop on Using Mechanistic Information in Forming Chemical Categories, OECD, Paris
-
M. Hayashi and Y. Sakuratani, Hemolytic anemia induced by anilines and nephrotoxicity induced by 4-aminophenols, in OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 138, Report of the Workshop on Using Mechanistic Information in Forming Chemical Categories, OECD, Paris, 2011, pp. 140-167.
-
(2011)
Hemolytic anemia induced by anilines and nephrotoxicity induced by 4-aminophenols, in OECD Environment, Health and Safety Publications Series on Testing and Assessment
, pp. 140-167
-
-
Hayashi, M.1
Sakuratani, Y.2
-
7
-
-
84871217523
-
Development of an evaluation support system for estimating repeated dose toxicity of chemicals based on chemical structure
-
In: Wilson A.G.E., editors Cambridge,: Royal Society of Chemistry
-
Hayashi, M. and Sakuratani, Y. 2011. " Development of an evaluation support system for estimating repeated dose toxicity of chemicals based on chemical structure ". In New Horizons in Toxicity Prediction, Edited by: Wilson, A.G.E. 26 - 37. Cambridge: Royal Society of Chemistry.
-
(2011)
New Horizons in Toxicity Prediction
, pp. 26-37
-
-
Hayashi, M.1
Sakuratani, Y.2
-
8
-
-
84863100268
-
A category approach to predicting the hemolytic effects of ethylene glycol alkyl ethers in repeated-dose toxicity
-
Yamada, T., Tanaka, Y., Zhang, H.Q., Hasegawa, R., Sakuratani, Y., Yamada, J. and Hayashi, M. 2012. A category approach to predicting the hemolytic effects of ethylene glycol alkyl ethers in repeated-dose toxicity. J. Toxicol. Sci, 37: 503 - 515.
-
(2012)
J. Toxicol. Sci
, vol.37
, pp. 503-515
-
-
Yamada, T.1
Tanaka, Y.2
Zhang, H.Q.3
Hasegawa, R.4
Sakuratani, Y.5
Yamada, J.6
Hayashi, M.7
-
9
-
-
84871255624
-
Categorization of nitrobenzene for repeated dose toxicity based on adverse outcome pathway
-
Sakuratani, Y., Zhang, H.Q., Nishikawa, S., Yamazaki, K., Yamada, T., Yamada, J. and Hayashi, M. 2013. Categorization of nitrobenzene for repeated dose toxicity based on adverse outcome pathway. SAR QSAR Environ. Res, 24: 35 - 46.
-
(2013)
SAR QSAR Environ. Res
, vol.24
, pp. 35-46
-
-
Sakuratani, Y.1
Zhang, H.Q.2
Nishikawa, S.3
Yamazaki, K.4
Yamada, T.5
Yamada, J.6
Hayashi, M.7
-
10
-
-
85195008663
-
-
Japan Existing Chemical Data Base (JECDB), National Institute of Health Sciences (NIHS), Tokyo. Available at
-
Japan Existing Chemical Data Base (JECDB), National Institute of Health Sciences (NIHS), Tokyo. Available at http://dra4.nihs.go.jp/mhlw_data/jsp/SearchPageENG.jsp.
-
-
-
-
11
-
-
85195000608
-
-
NITE: Toxicity Test Results, National Institute of Technology and Evaluation (NITE), Tokyo. Available at:
-
NITE: Toxicity Test Results, National Institute of Technology and Evaluation (NITE), Tokyo. Available at: http://www.safe.nite.go.jp/japan/sougou/view/IntrmSrchOecdTgList_jp.faces.
-
-
-
-
12
-
-
85195009545
-
-
Combined Repeat Dose and Reproductive/Developmental Toxicity Screening Test (OECD-TG422)by Ministry of Ministry of Economy, Trade and Industry, National Institute of Technology and Evaluation (NITE), Tokyo. Available at:
-
Combined Repeat Dose and Reproductive/Developmental Toxicity Screening Test (OECD-TG422)by Ministry of Ministry of Economy, Trade and Industry, National Institute of Technology and Evaluation (NITE), Tokyo. Available at: http://www.safe.nite.go.jp/japan/sougou/view/IntrmSrchOecdTgList_jp.faces
-
-
-
-
13
-
-
85195009874
-
-
US National Toxicology Program (NTP), Short-Term Study Abstracts, NTP, Washington DC. Available at:
-
US National Toxicology Program (NTP), Short-Term Study Abstracts, NTP, Washington DC. Available at: http://ntp.niehs.nih.gov/index.cfm?objectid=0847F4F0-E88B-51DA-B71C0FE0476B8AB2
-
-
-
-
14
-
-
85194991639
-
-
US National Toxicology Program (NTP), Long-Term Study Reports & Abstracts, NTP, Washington DC. Available at:
-
US National Toxicology Program (NTP), Long-Term Study Reports & Abstracts, NTP, Washington DC. Available at: http://ntp.niehs.nih.gov/index.cfm?objectid=084801F0-F43F-7B74-0BE549908B5E5C1C.
-
-
-
-
15
-
-
0028566014
-
Biotransformation and toxicity of halogenated benzenes
-
den Besten, C., Brouwer, A., Rietjens, I.M. and van Bladeren, P.J. 1994. Biotransformation and toxicity of halogenated benzenes. Hum. Exp. Toxicol, 13: 866 - 875.
-
(1994)
Hum. Exp. Toxicol
, vol.13
, pp. 866-875
-
-
den Besten, C.1
Brouwer, A.2
Rietjens, I.M.3
van Bladeren, P.J.4
-
16
-
-
33846881820
-
Structure-activity relationships for halobenzene induced cytotoxicity in rat and human hepatocytes
-
Chan, K., Jensen, N.S., Silber, P.M. and O'Brien, P.J. 2007. Structure-activity relationships for halobenzene induced cytotoxicity in rat and human hepatocytes. Chem. Biol. Interact, 63: 165 - 174.
-
(2007)
Chem. Biol. Interact
, vol.63
, pp. 165-174
-
-
Chan, K.1
Jensen, N.S.2
Silber, P.M.3
O'Brien, P.J.4
-
17
-
-
0018825719
-
Metabolic activation and detoxification of bromobenzene leading to cytotoxicity
-
Lau, S.S., Abrams, G.D. and Zannoni, V.G. 1980. Metabolic activation and detoxification of bromobenzene leading to cytotoxicity. J. Pharmacol. Exp. Ther, 214: 703 - 708.
-
(1980)
J. Pharmacol. Exp. Ther
, vol.214
, pp. 703-708
-
-
Lau, S.S.1
Abrams, G.D.2
Zannoni, V.G.3
-
18
-
-
0026524152
-
Bromobenzene-glutathione excretion into bile reflects toxic activation of bromobenzene in rats
-
Madhua, C. and Klaassen, C.D. 1992. Bromobenzene-glutathione excretion into bile reflects toxic activation of bromobenzene in rats. Toxicol. Lett, 60: 227 - 236.
-
(1992)
Toxicol. Lett
, vol.60
, pp. 227-236
-
-
Madhua, C.1
Klaassen, C.D.2
-
19
-
-
0018872812
-
The distribution excretion and biotransformation of p-dichloro[14C]benzene in rats after repeated inhalation, oral and subcutaneous doses
-
Hawkins, D.R., Chasseaud, L.F., Woodhouse, R.N. and Cresswell, D.G. 1980. The distribution excretion and biotransformation of p-dichloro[14C]benzene in rats after repeated inhalation, oral and subcutaneous doses. Xenobiotica, 10: 81 - 95.
-
(1980)
Xenobiotica
, vol.10
, pp. 81-95
-
-
Hawkins, D.R.1
Chasseaud, L.F.2
Woodhouse, R.N.3
Cresswell, D.G.4
-
20
-
-
0025988466
-
The liver, kidney, and thyroid toxicity of chlorinated benzenes
-
den Besten, C., Vet, J.J., Besselink, H.T., Kiel, G.S., van Berkel, B.J., Beemsn, R. and van Bladeren, P.J. 1991. The liver, kidney, and thyroid toxicity of chlorinated benzenes. Toxicol. Appl. Pharmacol, 111: 69 - 81.
-
(1991)
Toxicol. Appl. Pharmacol
, vol.111
, pp. 69-81
-
-
den Besten, C.1
Vet, J.J.2
Besselink, H.T.3
Kiel, G.S.4
van Berkel, B.J.5
Beemsn, R.6
van Bladeren, P.J.7
-
21
-
-
0025935620
-
Metabolic activation of 1,2,4-trichlorobenzene and pentachlorobenzene by rat liver microsomes: a major role for quinone metabolites
-
den Besten, C., Smink, M.C., de Vries, E.J. and van Bladeren, P.J. 1991. Metabolic activation of 1,2,4-trichlorobenzene and pentachlorobenzene by rat liver microsomes: a major role for quinone metabolites. Toxicol. Appl. Pharmacol, 108: 223 - 233.
-
(1991)
Toxicol. Appl. Pharmacol
, vol.108
, pp. 223-233
-
-
den Besten, C.1
Smink, M.C.2
de Vries, E.J.3
van Bladeren, P.J.4
-
22
-
-
0026473248
-
The involvement of primary and secondary metabolism in the covalent binding of 1,2- and 1,4-dichlorobenzenes
-
den Besten, C., Ellenbroek, M., van der Ree, M.A., Rietjens, I.M. and van Bladeren, P.J. 1992. The involvement of primary and secondary metabolism in the covalent binding of 1,2- and 1,4-dichlorobenzenes. Chem. Biol. Interact, 84: 259 - 275.
-
(1992)
Chem. Biol. Interact
, vol.84
, pp. 259-275
-
-
den Besten, C.1
Ellenbroek, M.2
van der Ree, M.A.3
Rietjens, I.M.4
van Bladeren, P.J.5
-
23
-
-
0022399902
-
Toxicity of aromatic disulphides. I. Generation of superoxide radical and hydrogen peroxide by aromatic disulphides in vitro
-
Munday, R. 1985. Toxicity of aromatic disulphides. I. Generation of superoxide radical and hydrogen peroxide by aromatic disulphides in vitro. J. Appl. Toxicol, 5: 402 - 408.
-
(1985)
J. Appl. Toxicol
, vol.5
, pp. 402-408
-
-
Munday, R.1
-
24
-
-
0022369703
-
Toxicity of aromatic disulphides. II. Intraerythrocytic hydrogen peroxide formation and oxidative damage by aromatic disulphides
-
Munday, R. 1985. Toxicity of aromatic disulphides. II. Intraerythrocytic hydrogen peroxide formation and oxidative damage by aromatic disulphides. J. Appl. Toxicol, 5: 409 - 413.
-
(1985)
J. Appl. Toxicol
, vol.5
, pp. 409-413
-
-
Munday, R.1
-
25
-
-
85194996118
-
-
OECD QSAR Toolbox (version 2.3), OECD, Paris. Available at:
-
OECD QSAR Toolbox (version 2.3), OECD, Paris. Available at: http://www.oecd.org/document/54/0,3746,en_2649_37465_42923638_1_1_1_37465,00.html
-
-
-
-
26
-
-
85195000535
-
-
Organisation for Economic Co-operation and Development (OECD), OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 102: Guidance Document for Using The OECD (Q)SAR Application Toolbox To Develop Chemical Categories According to the OECD Guidance on Grouping of Chemicals, OECD, Paris, 2009
-
Organisation for Economic Co-operation and Development (OECD), OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 102: Guidance Document for Using The OECD (Q)SAR Application Toolbox To Develop Chemical Categories According to the OECD Guidance on Grouping of Chemicals, OECD, Paris, 2009.
-
-
-
-
27
-
-
85194994345
-
-
Organisation for Economic Co-operation and Development (OECD), OECD Environment, (Q)SAR Application Toolbox Version 1.1 Strategies for Grouping Chemicals for Data Gap Filling for Acute Aquatic Toxicity Endpoints, OECD, Paris, 2010
-
Organisation for Economic Co-operation and Development (OECD), OECD Environment, (Q)SAR Application Toolbox Version 1.1 Strategies for Grouping Chemicals for Data Gap Filling for Acute Aquatic Toxicity Endpoints, OECD, Paris, 2010.
-
-
-
-
28
-
-
79952602472
-
Non-testing approaches under REACH - help or hindrance? Perspectives from a practitioner within industry
-
Patlewicz, G., Chena, M.W. and Bellina, C.A. 2010. Non-testing approaches under REACH - help or hindrance? Perspectives from a practitioner within industry. SAR QSAR Environ. Res, 22: 67 - 88.
-
(2010)
SAR QSAR Environ. Res
, vol.22
, pp. 67-88
-
-
Patlewicz, G.1
Chena, M.W.2
Bellina, C.A.3
-
29
-
-
0029828739
-
Differences in cytochrome p450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment
-
Hissink, A.M., Oudshoorn, M.J., van Ommen, B., Haenen, G.R.M.M. and van Bladeren, P.J. 1996. Differences in cytochrome p450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment. Chem. Res. Toxicol, 9: 1249 - 1256.
-
(1996)
Chem. Res. Toxicol
, vol.9
, pp. 1249-1256
-
-
Hissink, A.M.1
Oudshoorn, M.J.2
van Ommen, B.3
Haenen, G.R.M.M.4
van Bladeren, P.J.5
-
30
-
-
0018872812
-
The distribution, excretion and biotransformation of p-dichloro[14C]benzene in rats after repeated inhalation, oral and subcutaneous doses
-
Hawkins, D.R., Chasseaud, L.F., Woodhouse, R.N. and Cresswell, D.G. 1980. The distribution, excretion and biotransformation of p-dichloro[14C]benzene in rats after repeated inhalation, oral and subcutaneous doses. Xenobiotica, 10: 81 - 95.
-
(1980)
Xenobiotica
, vol.10
, pp. 81-95
-
-
Hawkins, D.R.1
Chasseaud, L.F.2
Woodhouse, R.N.3
Cresswell, D.G.4
-
31
-
-
85195017120
-
-
Hazard Evaluation Support System Integrated Platform (HESS), National Institute of Technology and Evaluation (NITE), Tokyo. Available at
-
Hazard Evaluation Support System Integrated Platform (HESS), National Institute of Technology and Evaluation (NITE), Tokyo. Available at http://www.safe.nite.go.jp/english/kasinn/qsar/hess-e.html.
-
-
-
|