Differences in cytochrome P450-mediated biotransformation of 1,2- dichlorobenzene by rat and man: Implications for human risk assessment

Chemical Research in Toxicology

Volumn 9, Issue 8, 1996, Pages 1249-1256

  Hissink, Arendina M ^a,b   Oudshoorn, Martin J ^a   Van Ommen, Ben ^a   Haenen, Guido R M M ^a   Van Bladeren, Peter J ^a  

^a TNO   (Netherlands)

^b Utrecht Toxicological Center (UTOX)   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DICHLOROBENZENE; ASCORBIC ACID; CYTOCHROME P450; EPOXIDE HYDROLASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; ISONIAZID; PHENOBARBITAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; HUMAN; HUMAN CELL; HYDROLYSIS; LIVER MICROSOME METABOLISM; LIVER TOXICITY; MALE; NONHUMAN; RAT;

ANIMALS; BIOTRANSFORMATION; CHLOROBENZENES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; INSECTICIDES; ISOENZYMES; MALE; MICROSOMES, LIVER; PROTEIN BINDING; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RISK ASSESSMENT; SPECIES SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0029828739     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx960058k     Document Type: Article

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