Benzophenone guttiferone a from Garcinia achachairu rusby (Clusiaceae) presents genotoxic effects in

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Terrazas, Peterson Menezes ^a   De Marques, Eduardo Souza ^a   Mariano, Luisa Nathália Bolda ^b   Cechinel Filho, Valdir ^b   Niero, Rivaldo ^b   Andrade, Sergio Faloni ^b   Maistro, Edson Luis ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOPHENONE DERIVATIVE; DOXORUBICIN; GUTTIFERONE A; UNCLASSIFIED DRUG; BENZOPHENONE; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BRAIN CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DOSE RESPONSE; ERYTHROCYTE; GARCINIA; GARCINIA ACHACHAIRU; GENOTOXICITY; IN VIVO STUDY; LEUKOCYTE; LIVER CELL; MALE; MOUSE; NONHUMAN; SINGLE DRUG DOSE; TESTIS CELL; ANIMAL; BONE MARROW; BRAIN; CHEMISTRY; DRUG EFFECTS; LIVER; TESTIS;

ANIMALS; BENZOPHENONES; BONE MARROW; BRAIN; DNA DAMAGE; GARCINIA; LEUKOCYTES; LIVER; MALE; MICE; PLANT EXTRACTS; TESTIS;

EID: 84892641907     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076485     Document Type: Article

References (24)

1. Ampofo SA, Waterman PG (1986) Xanthones and neoflavonoids from two Asian species of Calophyllum. Phytochemistry 25: 2617-2620. doi: 10.1016/S0031- 9422(00)84521-5.
2. Barbosa W, Artiole FA (2007) A fruta achachairu. Available: http://www.infobibos.com/Artigos/2007-1/achachairu/index.htm. (Acessed 18 April 2013).
3. Alves TMA, Silva AF, Brandão M, Grandi TSM, Smânia EF et al. (2000) Biological Screening of Brazilian Medicinal Plants. Mem Inst Oswaldo Cruz 95: 367-373. doi:10.1590/S0074-02762000000300012. PubMed: 10800195.
4. Barbosa W, Chagas EA, Martins L, Pio R, Tucci ML et al. (2008) Germinação de sementes e desenvolvimento inicial de plântulas de achachairu. Rev Bras Frutic 30: 263-266. doi:10.1590/S0100- 29452008000100049.
5. Molin MMD, Silva S, Alves DR, Quintão NLM, Monache FD et al. (2012) Phytochemical analysis analysis and antinociceptive properties of Garcinia achachairu Rusby (Clusiaceae) seeds. Arch Pharm Res 35: 623-631. doi:10.1007/s12272-012-0405-3. PubMed: 22553054.
6. Marques ES, Silva S, Niero R, Andrade SF, Rosa PCP et al. (2012) Genotoxicity assessment of GarciniaachachairuRusby (Clusiaceae) extract in mammalian cells in vivo. J Ethnopharmacol 142: 362-366. doi:10.1016/j.jep.2012. 04.045. PubMed: 22609977.
7. Acuña UM, Jancovski N, Kennelly EJ (2009) Polyisoprenylated benzophenones from Clusiaceae: potential drugs and lead compounds. Curr Top Med Chem 9: 1560-1580. doi:10.2174/156802609789909830. PubMed: 19903162.
8. Niero R, Dal Molin MM, Silva S, Damian NS, Maia LO et al. (2012) Gastroprotective effects of extracts and guttiferone A isolated from Garcinia achachairu Rusby (Clusiaceae) against experimentally induced gastric lesions in mice. NaunynSchmiedebergs Arch. Pharmacologist 385(11): 1103-1109.
9. Dal Molin MM, Silva S, Alves DR, Quintão NLM, Delle Monache F et al. (2012) Phytochemical analysis and antinociceptive properties of Garcinia achachairu Rusby (Clusiaceae) seeds. Arch Pharm Res 35: 623-631. doi:10.1007/s12272-012-0405-3. PubMed: 22553054.
10. Speit G, Hartmann A (1999) The comet assay (single-cell gel test), in: DS Henderson, Methods in Molecular Biology, Vol. 113, DNA Repair Protocols: Eukaryotic Systems. Totowa, NJ: Humana Press Inc. pp. 203-212.
11. Burlinson B, Tice RR, Speit G, Agurell E, Brendler-Schwaab SY et al. (2007) Fourth international workgroup on genotoxicity testing: results of the in vivo comet assay workgroup. Mutat Res 627: 31-35. doi:10.1016/j.mrgentox.2006. 08.011. PubMed: 17118697.
12. Hartmann A, Speit G (1997) The contribution of cytotoxicity to DNA - effects in the single cell gel test (comet assay). Toxicol Lett90: 183-188. doi:10.1016/S0378-4274(96)03847-7. PubMed: 9067486.
13. Schmid W (1976) The micronucleous test. Mutat Res31: 9-15.
14. Krishna G, Hayashi M (2000) In vivo rodent micronucleus assay: protocol, conduct and data interpretation. Mutat-Res 455: 155-166. PubMed: 11113474.
15. Gollapudi BB, McFadden LG (1995) Sample size for the estimation of polychromatic to normochromaticerithrocyte ratio in the bone marrow micronucleus test. Mutat Res347: 97-99. doi: 10.1016/0165-7992(95)90076-4. PubMed: 7651470.
16. Beerhues L (1996) Benzophenone synthase from cultured cells of Centaurium erythraea. FEBS Lett 383: 264-266. doi: 10.1016/0014-5793(96)00265-7. PubMed: 8925910.
17. ICH (1997) Genotoxicity, A standard Battery for Genotoxicity Testing of Pharmaceuticals Guideline S2B. International. Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use.
18. Smith CC, Adkins DJ, Martin EA, O'Donovan R (2008) Recommendations for design of the rat comet assay. Mutagenesis 23: 233-240. doi:10.1093/mutage/ gen008. PubMed: 18326531.
19. MacGregor JT, Heddle JA, Hite M, Margolin BH, Ramel C et al. (1987) Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes. Mutat Res 189: 103-112. doi: 10.1016/0165-1218(87)90016-4. PubMed: 3657826.
20. Fenech M (2000) The in vitro micronucleus technique. Mutat Res 455: 81-95. doi:10.1016/S0027-5107(00)00065-8. PubMed: 11113469.
21. Wu CC, Weng JR, Won SJ, Lin CN (2005) Constituents of the pericarp of Garciniasubelliptica. J Nat Prod 68: 1125-1127. doi:10.1021/np050084v. PubMed: 16038565.
22. Wu CC, Lu YH, Wei BL, Yang SC, Won SJ et al. CN (2008) Phloroglucinols with prooxidant activity from Garciniasubelliptica. J Nat Prod 71: 246-250. doi:10.1021/np070507o. PubMed: 18166016.
23. Almanza GR, Quispe R, Mollinedo P, Rodrigo G, Fukushima O et al. (2011) Antioxidant and antimutagenic polyisoprenylated benzophenones and xanthones from Rheedia acuminata. Nat Prod Commun 6: 1269-1274. PubMed: 21941896.
24. Kada T, Ivbone T, Namiki N (1982) Environmental desmutagens and antimutagens. In EJ Klekowshi, Environmental Mutagenesis and Plant Biology. New York: Praeger. pp. 137-151.