Apparent variation in Neanderthal admixture among African populations is consistent with gene flow from non-African populations

Genome Biology and Evolution

Volumn 5, Issue 11, 2013, Pages 2075-2081

  Wang, Shuoguo ^a,b   Lachance, Joseph ^c   Tishkoff, Sarah A ^c   Hey, Jody ^a   Xing, Jinchuan ^a,b  

^a Rutgers University   (United States)

^b Life Sciences Building Rutgers University   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Human evolution; Neanderthal admixture; Whole genome sequencing

Indexed keywords

AFRICA SOUTH OF THE SAHARA; ANIMAL; ARTICLE; BLACK PERSON; EVOLUTION; GENE FLOW; GENETICS; HOMO NEANDERTHALENSIS; HUMAN; MOLECULAR EVOLUTION; NEANDERTHAL ADMIXTURE; SINGLE NUCLEOTIDE POLYMORPHISM; WHOLE-GENOME SEQUENCING;

HUMAN EVOLUTION; NEANDERTHAL ADMIXTURE; WHOLE-GENOME SEQUENCING;

AFRICA SOUTH OF THE SAHARA; AFRICAN CONTINENTAL ANCESTRY GROUP; ANIMALS; EVOLUTION, MOLECULAR; GENE FLOW; HUMANS; NEANDERTHALS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84892638818     PISSN: None     EISSN: 17596653     Source Type: Journal    
DOI: 10.1093/gbe/evt160     Document Type: Article

References (23)

1. Alexander DH, Novembre J, Lange K. 2009. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 19:1655-1664.
2. Bryc K, et al. 2010. Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A. 107:786-791.
3. Campbell MC, Tishkoff SA. 2010. The evolution of human genetic and phenotypic variation in Africa. Curr Biol. 20:R166-R173.
4. Drmanac R, et al. 2010. Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays. Science 327:78-81.
5. Durand EY, Patterson N, Reich D, Slatkin M. 2011. Testing for ancient admixture between closely related populations. Mol Biol Evol. 28:2239-2252.
6. Eriksson A, Manica A. 2012. Effect of ancient population structure on the degree of polymorphism shared between modern human populations and ancient hominins. Proc Natl Acad Sci U S A. 109:13956-13960.
7. Green RE, et al. 2010. A draft sequence of the Neandertal genome. Science 328:710-722.
8. Gronau I, Hubisz MJ, Gulko B, Danko CG, Siepel A. 2011. Bayesian inference of ancient human demography from individual genome sequences. Nat Genet. 43:1031-1034.
9. Hammer MF, Woerner AE, Mendez FL, Watkins JC, Wall JD. 2011. Genetic evidence for archaic admixture in Africa. Proc Natl Acad Sci U S A. 108:15123-15128.
10. Keinan A, Mullikin JC, Patterson N, Reich D. 2007. Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans. Nat Genet. 39:1251-1255.
11. Kimura M, Ohta T. 1973. The age of a neutral mutant persisting in a finite population. Genetics 75:199-212.
12. Lachance J, et al. 2012. Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African huntergatherers. Cell 150:457-469.
13. Patterson N, et al. 2012. Ancient admixture in human history. Genetics 192:1065-1093.
14. Purcell S, et al. 2007. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 81:559-575.
15. Sanchez-Quinto F, et al. 2012. North African populations carry the signature of admixture with Neandertals. PLoS One 7:e47765.
16. Sankararaman S, Patterson N, Li H, Paabo S, Reich D. 2012. The date of interbreeding between Neandertals and modern humans. PLoS Genet. 8:e1002947.
17. Schuster SC, et al. 2010. Complete Khoisan and Bantu genomes from southern Africa. Nature 463:943-947.
18. Skoglund P, Jakobsson M. 2011. Archaic human ancestry in East Asia. Proc Natl Acad Sci U S A. 108:18301-18306.
19. Stewart JR, Stringer CB. 2012. Human evolution out of Africa: the role of refugia and climate change. Science 335:1317-1321.
20. Tishkoff SA, et al. 2007. History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variation. Mol Biol Evol. 24:2180-2195.
21. Tishkoff SA, et al. 2009. The genetic structure and history of Africans and African Americans. Science 324:1035-1044.
22. Wall JD, et al. 2013. Higher levels of neanderthal ancestry in East Asians than in Europeans. Genetics 194:199-209.
23. Yang MA, Malaspinas AS, Durand EY, Slatkin M. 2012. Ancient structure in Africa unlikely to explain neanderthal and non-African genetic similarity. Mol Biol Evol. 29:2987-2995.