A recall-by-genotype study of CHRNA5-A3-B4 genotype, cotinine and smoking topography: Study protocol

BMC Medical Genetics

Volumn 15, Issue 1, 2014, Pages

  Ware, Jennifer J ^a,b   Timpson, Nic ^a,b   Davey Smith, George ^a,b   Munafò, Marcus R ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE)   (United Kingdom)

Author keywords

CHRNA3; CHRNA5; Cotinine; Genetics; Smoking; Smoking topography

Indexed keywords

CIGARETTE SMOKE; COTININE; NICOTINIC RECEPTOR;

ADULT; ARTICLE; CHROMOSOME 15; FAMILY STUDY; GENE CLUSTER; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOTE; HUMAN; INHALATION; LONGITUDINAL STUDY; OUTCOME ASSESSMENT; PHENOTYPE; RECALL BY GENOTYPE; SALIVA LEVEL; SMOKING; TOPOGRAPHY; YOUNG ADULT;

NEPTUNIA;

ADULT; CHILD; COTININE; ENVIRONMENTAL EXPOSURE; FEMALE; GENOTYPE; HUMANS; MALE; MULTIGENE FAMILY; NERVE TISSUE PROTEINS; NICOTINE; RECEPTORS, NICOTINIC; SMOKING; SOCIAL CONTROL, INFORMAL;

EID: 84892632498     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-15-13     Document Type: Article

References (20)

1. Lessov CN, Martin NG, Statham DJ, Todorov AA, Slutske WS, Bucholz KK, Heath AC, Madden PA. Defining nicotine dependence for genetic research: evidence from Australian twins. Psychol Med 2004, 34:865-879. 10.1017/S0033291703001582, 15500307.
2. Munafo MR, Johnstone EC. Genes and cigarette smoking. Addiction 2008, 103:893-904. 10.1111/j.1360-0443.2007.02071.x, 18190672.
3. Kendler KS, Neale MC, Sullivan P, Corey LA, Gardner CO, Prescott CA. A population-based twin study in women of smoking initiation and nicotine dependence. Psychol Med 1999, 29:299-308. 10.1017/S0033291798008022, 10218922.
4. Sullivan PF, Kendler KS. The genetic epidemiology of smoking. Nicotine Tobacco Res 1999, 1(2):S51-S57.
5. Fowler T, Lifford K, Shelton K, Rice F, Thapar A, Neale MC, McBride A, van den Bree MB. Exploring the relationship between genetic and environmental influences on initiation and progression of substance use. Addiction 2007, 102:413-422. 10.1111/j.1360-0443.2006.01694.x, 1974769, 17298649.
6. Furberg H, Kim Y, Dackor J, Boerwinkle E, Franceschini N, Ardissino D, Bernardinelli L, Mannucci P, Mauri F. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 2010, 42:441-447. 10.1038/ng.571, 2914600, 20418890.
7. Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, Berrettini W, Knouff CW, Yuan X, Waeber G, et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 2010, 42:436-440. 10.1038/ng.572, 3612983, 20418889.
8. Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F, Sulem P, Rafnar T, Esko T, Walter S, et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 2010, 42:448-453. 10.1038/ng.573, 3080600, 20418888.
9. Fowler CD, Lu Q, Johnson PM, Marks MJ, Kenny PJ. Habenular alpha5 nicotinic receptor subunit signalling controls nicotine intake. Nature 2011, 471:597-601. 10.1038/nature09797, 3079537, 21278726.
10. Keskitalo K, Heloidie BU, vaara M, Ripatti S, Surakka I, Perola M, PitkÃ{currency sign}niemi J, Peltonen L, Aromaa A, Kaprio J. Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. Hum Mol Genet 2009, 18:4007-4012. 10.1093/hmg/ddp322, 2748889, 19628476.
11. Le Marchand L, Derby KS, Murphy SE, Hecht SS, Hatsukami D, Carmella SG, Tiirikainen M, Wang H. Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer Res 2008, 68:9137-9140. 10.1158/0008-5472.CAN-08-2271, 2587068, 19010884.
12. Munafo MR, Timofeeva MN, Morris RW, Prieto-Merino D, Sattar N, Brennan P, Johnstone EC, Relton C, Johnson PC, Walther D, et al. Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. J Natl Cancer Inst 2012, 104:740-748. 10.1093/jnci/djs191, 3352832, 22534784.
13. McNeill A, Munafo MR. Reducing harm from tobacco use. J Psychopharmacol 2013, 27:13-18. 10.1177/0269881112458731, 23035032.
14. Strasser AA, Lerman C, Sanborn PM, Pickworth WB, Feldman EA. New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Drug Alcohol Depend 2007, 86:294-300. 10.1016/j.drugalcdep.2006.06.017, 16930853.
15. Ware JJ, van den Bree MB, Munafo MR. Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. Nicotine Tob Res 2011, 13:1167-1175. 10.1093/ntr/ntr118, 3223575, 22071378.
16. Heatherton TF, Kozlowski LT, Frecker RC, Fagerstrom KO. The fagerstrom test for nicotine dependence: a revision of the fagerstrom tolerance questionnaire. Br J Addict 1991, 86:1119-1127. 10.1111/j.1360-0443.1991.tb01879.x, 1932883.
17. Cox LS, Tiffany ST, Christen AG. Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings. Nicotine Tobacco Res 2001, 3:7-16.
18. Tiffany ST, Drobes DJ. The development and initial validation of a questionnaire on smoking urges. Br J Addict 1991, 86:1467-1476. 10.1111/j.1360-0443.1991.tb01732.x, 1777741.
19. Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 1988, 54:1063-1070.
20. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, et al. Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest 2013, 123:3378-3382. 10.1172/JCI67383, 3726159, 23867623.