Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia

Journal of Pediatric Surgery

Volumn 49, Issue 1, 2014, Pages 39-45

  Shue, Eveline H ^a   Schecter, Samuel C ^a   Gong, Wenhui ^a   Etemadi, Mozziyar ^a   Johengen, Michael ^a   Iqbal, Corey ^a   Derderian, S Christopher ^a   Oishi, Peter ^a   Fineman, Jeffrey R ^a   Miniati, Doug ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Congenital diaphragmatic hernia; DH; PDE5 inhibitors; Phosphodiesterase type 5 inhibitors; Pulmonary hypertension

Indexed keywords

CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; PLACEBO; TADALAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PLACENTA BARRIER; CONGENITAL DIAPHRAGM HERNIA; CONTROLLED STUDY; DRUG BLOOD LEVEL; EWE; FEMALE; FETUS; FETUS LUNG; LAMB; LUNG PARENCHYMA; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RESUSCITATION; WESTERN BLOTTING;

CONGENITAL DIAPHRAGMATIC HERNIA; DH; PDE5 INHIBITORS; PHOSPHODIESTERASE TYPE 5 INHIBITORS; PULMONARY HYPERTENSION;

ANIMALS; CARBOLINES; CYCLIC GMP; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENZYME INDUCTION; FEMALE; FETAL DISEASES; FETAL THERAPIES; HERNIA, DIAPHRAGMATIC; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; LUNG; MATERNAL-FETAL EXCHANGE; NITRIC OXIDE SYNTHASE TYPE III; ORGAN SIZE; PHOSPHODIESTERASE 5 INHIBITORS; PREGNANCY; RANDOM ALLOCATION; SECOND MESSENGER SYSTEMS; SHEEP;

EID: 84892617138     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2013.09.024     Document Type: Article

References (29)

1. M.R. Langham Jr., D.W. Kays, and D.J. Ledbetter et al. Congenital diaphragmatic hernia. Epidemiology and outcome Clin Perinatol 23 4 1996 671 688
2. R.A. Cortes, R.L. Keller, and T. Townsend et al. Survival of severe congenital diaphragmatic hernia has morbid consequences J Pediatr Surg 40 1 2005 36 45 [discussion 45-6]
3. B. Thebaud, J.C. Mercier, and A.T. Dinh-Xuan Congenital diaphragmatic hernia. A cause of persistent pulmonary hypertension of the newborn which lacks an effective therapy Biol Neonate 74 5 1998 323 336
4. D. Bohn Congenital diaphragmatic hernia Am J Respir Crit Care Med 166 7 2002 911 915
5. D. Miniati Pulmonary vascular remodeling Semin Pediatr Surg 16 2 2007 80 87
6. O. Boucherat, M.L. Franco-Montoya, and C. Delacourt et al. Defective angiogenesis in hypoplastic human fetal lungs correlates with nitric oxide synthase deficiency that occurs despite enhanced angiopoietin-2 and VEGF Am J Physiol Lung Cell Mol Physiol 298 6 2010 L849 L856
7. T. Yamataka, and P. Puri Pulmonary artery structural changes in pulmonary hypertension complicating congenital diaphragmatic hernia J Pediatr Surg 32 3 1997 387 390
8. R.L. Geggel, J.D. Murphy, and D. Langleben et al. Congenital diaphragmatic hernia: arterial structural changes and persistent pulmonary hypertension after surgical repair J Pediatr 107 3 1985 457 464
9. P. de Lagausie, A. de Buys-Roessingh, and L. Ferkdadji et al. Endothelin receptor expression in human lungs of newborns with congenital diaphragmatic hernia J Pathol 205 1 2005 112 118
10. N. Galie, B.H. Brundage, and H.A. Ghofrani et al. Tadalafil therapy for pulmonary arterial hypertension Circulation 119 22 2009 2894 2903
11. Mourani PM, Sontag MK, Ivy DD, et al. Effects of long-term sildenafil treatment for pulmonary hypertension in infants with chronic lung disease. J Pediatr 2009; 154(3): p. 379-84, 384 e1-2.
12. J.S. Stultz, T. Puthoff, and C. Backes Jr. et al. Intermittent intravenous sildenafil for pulmonary hypertension management in neonates and infants Am J Health Syst Pharm 70 5 2013 407 413
13. R.A. Samangaya, G. Mires, and A. Shennan et al. A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia Hypertens Pregnancy 28 4 2009 369 382
14. H. Mohseni-Bod, and D. Bohn Pulmonary hypertension in congenital diaphragmatic hernia Semin Pediatr Surg 16 2 2007 126 133
15. B. Thebaud, and D. Tibboel Pulmonary hypertension associated with congenital diaphragmatic hernia Cardiol Young 19 Suppl 1 2009 49 53
16. R. Dhillon The management of neonatal pulmonary hypertension Arch Dis Child Fetal Neonatal Ed 97 3 2012 F223 F228
17. Y. Taira, T. Yamataka, and E. Miyazaki et al. Comparison of the pulmonary vasculature in newborns and stillborns with congenital diaphragmatic hernia Pediatr Surg Int 14 1-2 1998 30 35
18. C. Luong, J. Rey-Perra, and A. Vadivel et al. Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia Circulation 123 19 2011 2120 2131
19. D. Montani, M.C. Chaumais, and L. Savale et al. Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension Adv Ther 26 9 2009 813 825
20. D.S. Celermajer, C. Dollery, and M. Burch et al. Role of endothelium in the maintenance of low pulmonary vascular tone in normal children Circulation 89 5 1994 2041 2044
21. A.J. North, R.A. Star, and T.S. Brannon et al. Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung Am J Physiol 266 6 Pt 1 1994 L635 L641
22. V. Solari, A.P. Piotrowska, and P. Puri Expression of heme oxygenase-1 and endothelial nitric oxide synthase in the lung of newborns with congenital diaphragmatic hernia and persistent pulmonary hypertension J Pediatr Surg 38 5 2003 808 813
23. A.J. North, F.R. Moya, and M.R. Mysore et al. Pulmonary endothelial nitric oxide synthase gene expression is decreased in a rat model of congenital diaphragmatic hernia Am J Respir Cell Mol Biol 13 6 1995 676 682
24. K.A. Fagan, B.W. Fouty, and R.C. Tyler et al. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia J Clin Invest 103 2 1999 291 299
25. Roessingh A. de Buys, V. Fouquet, and Y. Aigrain et al. Nitric oxide activity through guanylate cyclase and phosphodiesterase modulation is impaired in fetal lambs with congenital diaphragmatic hernia J Pediatr Surg 46 8 2011 1516 1522
26. B. Thebaud, T. Petit, and P. De Lagausie et al. Altered guanylyl-cyclase activity in vitro of pulmonary arteries from fetal lambs with congenital diaphragmatic hernia Am J Respir Cell Mol Biol 27 1 2002 42 47
27. M.E. Zussman, M. Bagby, and D.W. Benson et al. Pulmonary vascular resistance in repaired congenital diaphragmatic hernia vs. age-matched controls Pediatr Res 71 6 2012 697 700
28. S.M. Black, J.R. Fineman, and R.H. Steinhorn et al. Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension Am J Physiol 275 5 Pt 2 1998 H1643 H1651
29. Z.K. Dai, M.S. Tan, and C.Y. Chai et al. Effects of increased pulmonary flow on the expression of endothelial nitric oxide synthase and endothelin-1 in the rat Clin Sci (Lond) 103 Suppl. 48 2002 289S 293S